Biomedical subjects
L F Montes
Publications and source records attributed to L F Montes.
Basal cell epithelioma.
Explore the source record for details and available documents.
Low strength anthralin in psoriasis.
Anthralin in low concentrations (0.01%--0.03%) was applied in an ointment form once per day in the hospital to 130 psoriasis patients. The treatment program included also the use of UVB light, emollients and bath oil and an antihistamine. Clearing of psoriasis was achieved in all patients in an average time of 4 weeks. The involution of the lesions was carefully studied by correlated clinical observations, light microscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Striking healing of the holes in the stratum corneum and of the gaps in the basement membrane occurred. Low strength anthralin, in addition to its effectiveness, did not produce irritation, staining or side-effects.
Electron microscopic assay of a topical acne treatment: benzoyl peroxide acetone gel.
Explore the source record for details and available documents.
The histopathology of diaper dermatitis. Historical review.
The precise pathogenesis of one of the most common cutaneous disorders, diaper dermatitis, has not yet been completely established, perhaps in part because relatively little histopathological knowledge has been obtained. This paper summarizes the available information in this field, mostly obtained by early investigators.
Ultrastructural basis for the assay of topical acne treatments. Transmission and scanning electron microscopy of untreated comedones.
After two decades of using systemic antibiotics as a main treatment for acne, emphasis is again being placed on topical agents. Thus, it is highly desirable to have a procedure whereby the activity of the various compounds can be evaluated by direct visualization. Scanning electron microscopy combined with transmission electron microscopy provide the tools for such in assay. This study describes the ultrastructure of untreated comedones and provides the baseline or control data necessary for testing topical treatments. Comedones obtained by punch biopsies or comedo extractors were processed for electron microscopy and studied with an ETEC Autoscan Scanning Electron Microscope and with Philips EM 300 and EM 301 Transmission Electron Microscopes. Microorganisms, keratinized cells, sebum, and hairs interact with each other to form the comedonal mass. Corynebacterium acnes and Pityrosporum ovale proliferate abundantly in close association with sebum and penetrate the keratinized cells. Fine structural details of bacteria and yeasts as well as features of host-microbial relationship have been elucidated.
Subcutaneous fat necrosis of the newborn.
Subcutaneous fat necrosis of the newborn (SFNN) developed in a 1-week-old black boy. His mother had received numerous medications for eclampsia. Birth was by Caesarean section and complicated by meconium aspiration. There were numerous nodules over the back, buttocks and extremities that yielded a caseous-like material. Microscopically, these nodules showed crystallization and necrosis of the fat. Hypoglycemia, pneumonia, oliguria, thrombocytopenia, seizures and urinary infection were associated with the cutaneous problem and led to a fatal outcome 2 weeks after birth.
Ultrastructural identification of Langerhans cells in seborrheic keratoses.
Lesions of seborrheic keratoses studied by transmission electron microscopy showed an unusually large number of Langerhans cells in the epidermis. The role of Langerhans cells in the development of these lesions needs further study.
Clinical and antimicrobial effects of haloprogin cream in diaper dermatitis.
Haloprogin cream was applied four times a day for one week over the diaper area of eight infants affected by diaper dermatitis. All patients experienced complete clearing. Candida albicans was isolated from seven patients prior to treatment but failed to grow in cultures obtained after completion of the treatment.
Topical halcinonide in alopecia areata and in alopecia totalis.
Explore the source record for details and available documents.