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Biomedical subjects

L F Harris

Publications and source records attributed to L F Harris.

At least 73 records · Page 4Linked to original sources
PubMed1982

Reactivity of serum-armed xenogeneic macrophages to breast cancer antigens.

Sera from breast cancer patients contained cytophilic antibody which armed guinea pig peritoneal macrophages. These macrophages then exhibited specific adherence inhibition in the presence of tissue culture tumor antigens. These antigens were obtained from primary cultures of autologous or allogeneic breast cancer cells. Sera from control subjects for the most part did not induce macrophage adherence inhibition in the presence of these same antigens.

Animals↗
PubMed1981

Legionnaires' disease associated with acute encephalomyelitis.

A 26-year-old man had Legionnaires' disease associated with encephalomyelitis and abnormal CSF. Neurologic symptoms antedated the appearance of the pulmonary infiltrate and have persisted despite appropriate antibiotic therapy. A review of the literature revealed only one other similar case. Legionnaires' disease should be considered in the differential diagnosis of encephalomyelitis even in the absence of a pneumonic infiltrate.

Acute Disease↗
PubMed1981

Bacteremia and bacteriuria after transrectal prostatic biopsy.

To determine the efficacy of parenteral gentamicin versus povidone-iodine enema (P.I.E.) in preventing infectious complications, a randomized study was undertaken in 40 patients undergoing transrectal needle prostatic biopsy. In 69 per cent of patients not receiving P.I.E. bacteremia developed, and 32 per cent acquired bacteriuria; whereas only 19 per cent of patients given P.I.E. alone or in combination with gentamicin because bacteremic, and 9.5 per cent had postbiopsy bacteriuria. Thus, P.I.E. provided a safe and effective means for preventing most bacteremia and bacteriuria associated with transrectal biopsy of the prostate.

Adult↗
PubMed1980

Retroperitoneal abscess. Case report and review of the literature.

The case of a 93-year-old female with a Streptococcus pneumoniae retroperitoneal abscess diagnosed by physical examination and abdominal ultrasonography is presented. Review of the literature reveals no previous cases of Streptococcus pneumoniae retroperitoneal abscess. Retroperitoneal abscess is a complication of common medical diseases. Delay in diagnosis contributes to a high mortality rate and surgical drainage is the primary mode of therapy. The new diagnostic techniques of ultrasonography, radionucleotide scanning with gallium-67 citrate or indium-111 chloride, and computerized tomography appear to provide a sensitive method for earlier diagnosis.

Abscess↗
PubMed1980

Bacteremia related to IV cannulation: variability of underlying venous infection.

During 1977, 22 of 66 cases of nosocomial bacteremia in our hospital were directly or indirectly attributable to infection from the intravenous (IV) site. IV-site-related bacteremia (IVSRB) occurred most frequently in patients with serious underlying disease. The characteristic clinical picture was one of fever, tachycardia, and hypotension. Signs at the IV site appeared most commonly at the onset of IVSRB but varied in time of appearance from six days before to 11 days after bacteremia. The degree of abnormality at the IV site accompanying IVSRB varied from none detectable through uncomplicated cellulitis and phlebitis to vein suppuration. Short percutaneous plastic catheters were incriminated in most cases, and gram-negative rods, especially Klebsiella and Serratia, were the most frequent infecting bacteria. Initial treatment consisted of removal of the IV cannula and administration of parenteral antibiotics. Although no deaths could be attributed to recognized and treated IVSRB, it resulted in significant morbidity including the need for excision of veins contiguous with the IV site in six patients.

Anti-Bacterial Agents↗
PubMed1979

Lymphocyte transformation for the detection of herpesvirus-induced tumor-associated antigens.

Cell-mediated immunity to fibroblasts transformed by herpes simplex virus type 2 was investigated with a lymphocyte assay system. The assay system was first standardized with phytohemagglutinin, a nonspecific stimulator of blastogenesis. Hamster splenic and blood lymphocytes reacted to phytohemagglutinin with a dose-response curve similar to that reported for other rodent species. Splenic lymphocytes from hamsters bearing isografts, induced by herpes simplex virus type 2, were transformed by cell-free virus-induced tumor antigens. The reactions with cell-free tumor antigens were dose-dependent and paralleled the findings with phytohemagglutinin. The initial transformation response of immune lymphocytes to homologous tumor antigens occurred after 72 hr incubation with antigen. Immune splenic lymphocytes from hamsters were also significantly stimulated with antigens obtained from cells productively infected with herpes simplex virus type 2. Immune lymphocytes were not stimulated with heterologous antigens from simian virus 40-transformed mouse or hamster cells. Likewise, lymphocytes from hamsters sensitized to cells transformed by simian virus 40 reacted with both simian virus 40-transformed mouse and hamster cells but did not react with cells transformed by a heterologous virus. The results suggest that under defined conditions a lymphocyte transformation assay may be useful for the specific detection of common viral-induced antigens on tumor cells.

Animals↗
PubMed1978

Sodium clavulanate potentiation of cephalosporin activity against clinical isolates of cephalothin-resistant Klebsiella pneumoniae.

Plasmid-carrying Klebsiella pneunomiae clinical isolates with agar dilution minimum inhibitory concentrations (MIC) of 32 mug/ml or greater were tested for in vitro potentiation of cephalothin activity by clavulanic acid (BRL-14151), an inhibitor of beta-lactamases. The addition of 10 mug of clavulanate per ml caused greater than a 500-fold reduction in geometric mean cephalothin agar dilution MIC, with lesser but significant reductions resulting from clavulanate concentrations of 5 or 1 mug/ml. Clavulanate-potentiated reduction of cephalothin MICs in broth against resistant Klebsiella were comparable to reduction in agar dilution MICs as a rule. However, a low concentration (1 mug/ml) of clavulanate produced cephalothin MICs in broth several-fold higher than by the agar dilution method. Modest cephalothin-potentiating effects of clavulanate on cephalothin-susceptible strains and on cefoxitin against cephalothin-resistant Klebsiella strongly suggested that the major effect of clavulanate was beta-lactamase inhibition.

Amidohydrolases↗
PubMed1978

Anaerobic septicemia after transrectal prostatic biopsy.

Transrectal biopsy of the prostate resulted in anaerobic septicemia in two patients, despite parenteral gentamicin sulfate prophylaxis. Bacteroides fragilis sepsis developed subacutely in one patient having a postbiopsy pelvic abscess. Clostridium perfringens sepsis occurred fulminantly in another patient 24 hours after biopsy of a gland extensively involved with adenocarcinoma. These cases indicate a potential hazard of sepsis due to anaerobic contamination with rectal microflora at the time of transrectal prostatic biopsy and the futility of prophylaxis directed only at aerobic bacteria.

Adult↗