The Epstein-Barr virus (EBV) in human pathology. Results of a serological investigation of a hospital population.
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Biomedical subjects
Publications and source records attributed to L Enjalbert.
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Ninety patients were included in this prospective randomized trial. Each required electric colorectal surgery and was prepared for operation with oral preoperative antibiotic therapy, systemic peroperative therapy, or by a combination of both. The number of each type of septic postoperative complication and their total did not differ between the group treated by oral antibiotics prior to operation and the group treated peroperatively with systemic antibiotic therapy. The total number of septic complications (wall abscesses, fistulas, subdiaphragmatic abscesses, septicemia, peritonitis), however, was significantly less (P less than 0.05) in the group treated by both preoperative oral antibiotics and peroperative systemic antibiotic therapy (3.3 per cent) than in either groups treated only orally preoperatively (30 per cent) or by systemic antibiotic therapy during the operation (23 per cent). The combination of oral antibiotic therapy prior to operation and of systemic peroperative antibiotic therapy, therefore, presents the most effective prophylactic effectiveness.
Antibodies to EBV induced intracellular antigens, (VCA, EA, NA) and VCA-IgM antibodies have been investigated to define EBV serologic profile of 245 individuals. This profile was a first studied in EBV primary infections. In infectious mononucleosis, the efficiency of EBV serodiagnosis is lower than Paul Bunnel Davidsohn reaction (PBD) : primary infection profile is only characterised in 80% of the positive PBD infectious mononucleosis (IM). On the other hand, EBV antibodies are preponderant for diagnosis in other clinical manifestations of EBV primary-infection were PBD is not alwasy positive (47%). EBV antibodies of patients with various diseases and antibodies of normal subjects show different profiles. By interpretation of these profiles one discuss the possibility to characterize reinfection, and either latent or active persistant infection.
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