Search PubMed⌕ Search

Biomedical subjects

L Elsborg

Publications and source records attributed to L Elsborg.

At least 91 records · Page 5Linked to original sources
PubMed1978

Folate status during long-term therapy with trimethoprim and sulphadiazine.

It was studied whether treatment with sulphadiazine and trimethoprim for 8 weeks affected the folate status. The therapy did not inhibit the absorption as assessed by the 3H--folic acid absorption (TRIFA) test. Plasma folic acid clearance showed that folate deficiency had not developed. Bone marrow studies revealed that the antifolic action of the drugs did not manifest itself at the cellular level. The Lactobacillus casei method should not be employed in the determinations of the serum folate concentration during the treatment because therapeutic plasma concentrations of the two drugs inhibit the growth of the test bacteria.

Adult↗
PubMed1978

The final diagnosis in patients with normal barium enema.

This investigation, based on 139 consecutive patients subjected to barium enema, represent an attempt to supplement general clinical experience with exact data on the diagnostic value of radiographic examination of the colon. About one half of the patients suffered from diseases outside the gastrointestinal tract, and it is suggested that further research is needed to explain the complaints in this large group of patients. The age and sex of patients referred for examination were of special significance. The diagnostic value of the symptomatology is analysed, but no symptoms permit a prediction of the outcome of the x-ray examination.

Adult↗
PubMed1977

Gastrin concentrations in serum and gastric mucosa in patients with pernicious anaemia.

Sessile polyps in the antrum were found in 12 of 51 patients with pernicious anaemia. During gastroscopy, mucosal biopsies for gastrin determination were taken from the antrum and fundus and from the polyps. Patients with high gastrin concentration in the antral mucosa showed high serum gastrin concentrations, while most patients with low antral gastrin concentrations also had low serum gastrin values. On an average, the gastrin concentrations in the antrum were approximately 10 times, and those in the fundus approximately 100 times, higher than the corresponding values obtained in a reference group. The gastrin content in the polyps was not different from that in the surrounding antral mucosa. This study suggests that the polyps are not due to a functional hypertrophy of the antral mucosa caused by locally increased production of gastrin.

Adult↗
PubMed1977

Gastric mucosal polyps in pernicious anaemia.

In a 4-year follow-up study of 68 patients with pernicious anaemia gastric polyps were observed in 25 patients. In some patients the polyps seemed to vanish completely from one year to another, while they might ascen or increase in other patients. None of these polyps underwent malignanttransformation during thperiod f observation, and by histological examination they could be classified as non-neoplastic regenerative benign polyps in an atrophic gastric mucosa. In our opinion the surgical attitude to these nonneoplastic gastric polyps in pernicious anaemia should be restrictive.

Adult↗
PubMed1976

Serum vitamin B12 levels in the aged.

In an attempt to throw light on the question of age-related variations in the normal blood content of cobalamin and on the frequency of deficiencies of antimegaloblastic nutriments in the elderly, 273 geriatric patients have been investigated. Low serum vitamin B12 values were found in one third of these patients, due to latent pernicious anaemia in five and malabsorption in seven cases, and probably caused by nutritional deficiency of folate or cobalamin in 78 cases. In that part of the series with apparently normal vitamin B12 levels, the mean value (379+/-14 pg/ml) was lower than the mean (456+/-20 pg/ml) for a younger control group. However, this cannot be taken as a sign of a physiological lowering of the cobalamin values with age, as nutritional deficiencies could not be ruled out in this part of the series. It is concluded that serum vitamin B12 assays should be performed rather liberally in the aged. Patients with nutritional deficiency of cobalamin or folate should be treated, even if frank megaloblastic anaemia is not present.

Age Factors↗
PubMed1976

Reversible malabsorption of folic acid in the elderly with nutritional folate deficiency.

In normal subjects, the folic acid absorption (TRIFA test) was independent of age and sex. Among 53 geriatric patients with nutritional folate deficiency, impaired absorption of folic acid was present in 19 (36%). After treatment with folic acid for 4 weeks, the absorption returned to normal. It is concluded that folate deficiency per se can produce a malabsorption syndrome resulting in further depletion of folate. Protein deficiency and weight loss alone do not impair the absorption of folic acid.

Adult↗
PubMed1976

Nutritional studies on long-term surgical patients with special reference to the intake of vitamin B12 and folic acid.

A nutritional survey performed in 46 elderly long-term surgical patients in an orthopedic ward showed that, although a sufficient hospital diet was served, the intakes of vitamin B12 were borderline, while the intakes of folate were inadequate inmost patients. Low energy intake combined with a high consumption of titbits in bedridden patients was assumed to be responsible for this malnourishment.

Aged↗