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Biomedical subjects

L Elsborg

Publications and source records attributed to L Elsborg.

At least 55 records · Page 3Linked to original sources
PubMed1985

Effect of somatostatin in necrolytic migratory erythema of glucagonoma.

A 63-year-old woman with necrolytic migratory erythema associated with a glucagonoma in the pancreas is described. The diagnosis was suggested on the basis of a characteristic lesion in skin biopsy. Infusion of somatostatin (25 micrograms/h) for 48 hours was followed by a rapid and almost complete healing of the skin eruptions. Serum glucagon was depressed during infusion. No significant changes in plasma glucose were detected. As the patient experienced a cramp-like sensation after cessation of somatostatin infusion, a tail-off period in the infusion program is advocated. The pathogenesis of necrolytic erythema in glucagonoma is discussed.

Adenoma, Islet Cell↗
PubMed1985

Effect of sucralfate on gastroesophageal reflux in esophagitis.

Gastroesophageal reflux was assessed in 18 patients with endoscopically and histologically verified esophagitis, and 15 asymptomatic normal subjects, by a portable receiving system. The qualitative evaluation of the frequency of reflux episodes, normalized mean pH, normalized mean [H+] and the acid clearance rate is found to be indicative of gastroesophageal reflux. Twelve weeks of treatment with sucralfate in an open clinical trial resulted in a significant reduction of gastroesophageal reflux and the elimination of esophageal mucosal damage. Barrett++'s epithelium was found in a rather high proportion and proved to be resistant to treatment. It is suggested that the observed improvement is due to the barrier protecting properties of sucralfate restoring the motor function of the distal esophagus.

Adult↗
PubMed1984

[Enteral feeding].

Explore the source record for details and available documents.

Enteral Nutrition↗
PubMed1984

Sucralfate versus placebo treatment in duodenal and prepyloric ulcer: a clinical endoscopic, double-blind controlled investigation.

Sucralfate, which has cytoprotective, pepsinostatic, antacid and bile acid-binding properties, was studied in a therapeutic trial against a placebo in patients with duodenal and prepyloric ulcer. The investigation was designed as a double-blind controlled study. Thirty-five patients with endoscopically verified ulcers were observed during 8 weeks of treatment. In 14 out of 17 (82%) patients treated with sucralfate the ulcers healed, as compared with 7 out of 18 (39%) in the placebo group, as compared with 7 out of 18 (39%) in the placebo group. In approximately 60% of sucralfate-treated patients all symptoms disappeared, as compared with approximately 30% in the placebo group. No significant side effects were detected, and compliance was good. Consequently, sucralfate represents as effective and safe treatment for duodenal ulcer.

Adult↗
PubMed1983

The intake of vitamins and minerals by the elderly at home.

In 403 elderly people residing in their own homes a dietary interview was undertaken with special reference to the intakes of vitamins and minerals. The group was randomly selected. The data were compared with the Recommended Dietary Allowances, Joint Nordic Recommendations and the absolute minimal necessary amounts. Intakes of folacin was low in 100% of the interviewed, intakes of cholecalciferol was low in 62% and in 83% intakes of pyridoxine was low as compared to the recommendations. The majority had sufficient amounts of ascorbic acid, thiamine, riboflavin, retinol and cobalamin from the diet. The intake of zinc was low in 87% of the interviewed, but risk of zinc deficiency might only be present in 0.5%. The intakes of iron and calcium was judged to be sufficient. The physiological needs of the elderly may, however, vary from the standards used here and recommendations with special reference to the elderly are in request. The conclusion is that the diet of the elderly, possibly with exception of folacin, is well above their absolute minimal requirements, but the margin towards malnutrition is small. This means that elderly people should be considered a vulnerable group with respect to the intakes of vitamins and minerals.

Aged↗
PubMed1981

The folic acid absorption test compared with other laboratory tests for malabsorption.

In 25 patients with malabsorption, the folic acid urinary excretion (TRIFA) test was compared with the degree of steatorrhoea, the Schilling test, and the D-xylose test. No correlation was found between the faecal lipid excretion, the Schilling test, and the TRIFA test, whereas the TRIFA test did correlate fairly well with the D-xylose test. It is concluded that the TRIFA test does not replace estimations of faecal lipid excretions in the diagnosis of intestinal malabsorption. As it mainly supplies information about absorptional capacity in the upper small bowel, it is complementary to the Schilling test, which chiefly measures the absorption in the lower intestine. Finally, the TRIFA test has several advantages over the D-xylose test in practical clinical use.

Adolescent↗
PubMed1981

Disodium cromoglycate in the treatment of ulcerative colitis and Crohn's disease.

A controlled clinical study on disodium cromoglycate (DSCG) at a dose of 800 mg per day versus placebo was carried out in 141 patients with ulcerative colitis and 25 patients with Crohn's disease. Those of the ulcerative colitis patients who had been on sulphasalazine treatment continued that treatment during the trial (101 patients). Forty patients were intolerant of sulphasalazine. No patient received steroids during the last month before the study. Patients with Crohn's disease had their possible sulphasalazine treatment stopped before the trial. No beneficial effect of DSCG as compared with placebo was found, as the DSCG and the placebo group showed the same number of relapses in patients with a clinically inactive ulcerative colitis at the start of the trial and the same number of patients improving, deteriorating, and maintaining steady state in patients with clinically active ulcerative colitis at the start of the trial. There was no difference between relapse rate in DSCG and placebo groups in patients with Crohn's disease. No correlation between the eosinophil count in rectal mucosa and the outcome of the attack of ulcerative colitis could be demonstrated.

Clinical Trials as Topic↗
PubMed1981

Ethical aspects of clinical decision-making.

The aim of the present investigation was to describe and to classify significant ethical problems encountered by the members of the staff during the daily clinical work at a hospital medical department. A set of definitions was prepared for the purpose, including the definition of a 'significant ethical problem'. During a three month period 426 inpatients and 173 outpatients were admitted. Significant ethical problems were encountered during the management of 106 in-patients (25 per cent) and 9 out-patients (5 per cent). No significant difference was found between the frequency of ethical problems in female and male patients, but a positive correlation was noted between the number of problems and the patients' age. The problem types were classified according to a problem list. The results of this investigation suggest that greater attention must be paid to discussions about ethical problems among doctors and other categories of health personnel and that, among others, medical students ought to be taught the analysis of ethical problems.

Adolescent↗
PubMed1981

Endoscopic retrograde pancreatography and the exocrine pancreatic function in chronic alcoholism.

In a consecutive study of chronic alcoholics admitted for X-ray-negative dyspepsia, endoscopic retrograde pancreatography (ERP) showed pancreatographic changes in 47% of the patients, whereas exocrine pancreatic dysfunction was found in 19%. Only patients with severe parenchymatous damage on ERP had subnormal output of pancreas lipase. In patients with less severe pancreatographic changes the pancreas function test was normal. It was suggested that ERP is a more sensitive method for detection of minor and moderate duct abnormalities in pancreatic inflammatory disease. A clinical diagnosis of pancreatitis had been made in only 22% of the patients before the present investigation. Thus subclinical pancreatitis may be more frequent among alcoholics than previously recognized and should be suspected in cases of unclarified dyspepsia in patients with long-standing abuse of alcohol.

Adult↗