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Biomedical subjects

L Ekelund

Publications and source records attributed to L Ekelund.

At least 109 records · Page 6Linked to original sources

Transcatheter arterial embolization of experimental hepatic tumours in the rat.

After transcatheter arterial embolization with Spongostan (99.3% gelatin-similar to gelfoam) in a group of rats with experimental hepatic tumours, the angiographic and microscopic findings were compared with those in a group of rats with non-embolized liver tumours. Partial recanalization of the hepatic artery was demonstrated already after 2 to 6 days. Reduced vascularization of tumours could be demonstrated after embolization and in a few animals even decrease in tumour size. Microscopy revealed a significantly greater extent of tumour necrosis in embolized tumours of large size. Necrosis of normal liver tissue was found to a varying degree in the embolized rats, while no ischemic injury was evident in livers of most non-embolized animals.

Animals↗

Adrenal angiography in Sipple's syndrome.

Adrenal angiography was performed in 8 patients with Sipple's syndrome. Seven patients had pheochromocytomas and one bilateral adrenal medullary hyperplasia. In 4 cases the pheochromocytomas were bilateral. The angiographic findings are discussed and it is concluded that no typical angiographic appearance of pheochromocytoma appears to exist.

Adrenal Gland Neoplasms↗

Ultrasound, angiography and fine needle aspiration biopsy in diagnosis of renal neoplasms.

The diagnostic approach to a renal mass including ultrasound, angiography and fine needle aspiration biopsy is reviewed on the basis of 23 cases. The value of the combination of these methods is emphasized especially in tumors which appear without echoes at ultrasround and avascular-hypovascular at angiography. The findings are correlated and some differential diagnostic problems discussed as well as the possible risk of spreading tumor cells at fine needle aspiration biopsy.

Adenocarcinoma↗

Pseudotumor of the renal pelvis caused by renal artery aneusysm.

Urographic abnormalities caused by renal artery aneurysms are discussed on the basis of seven cases. Angiography is the diagnostic procedure of choice to make the correct diagnosis. In cases of completely thrombosed aneurysms angiography may only demonstrate an avascular mass with displacement of vessels. At ultrasound examination renal artery aneurysms should be included in the differential diagnosis of echo-free renal masses.

Adult↗

Percutaneous production of renal artery lesions. Experiments in the pig.

Percutaneous, intraarterial traumatization of both renal arteries in 4 pigs using the stiff end of a guide-wire resulted in intimal lesions in 7 arteries. At repeat angiography healing was demonstrated in 4 of these arteries, suggesting that spontaneous restitution may be more common than usually believed. Balloon catheter dilatation of 2 stenotic segments initially increased the diameter of the stenoses but at repeat angiography both arteries were found to be occluded. Over-distension of the balloon in the renal artery resulted in pseudoaneurysm in one case and rupture in the other.

Animals↗

Bilateral concurrent renal neoplasms: report of eleven cases.

Eleven patients with concurrent bilateral renal neoplasms are presented, including one case with dissimilar tumor histogenesis. In four cases urography showed only unilateral expansive lesions. The importance of high-dose nephrotomography and bilateral selective renal angiography is stressed. Literature review revealed 57 patients with concurrent bilateral renal cell carcinoma, indicating that this entity may be more frequent than previously believed.

Adenocarcinoma↗

Rehabilitation after hip fracture in the elderly.

Sixty-eight patients with hip fracture, mean age 79 years, from the city of Lund, were studied with special reference to functional and social rehabilitation at follow-up 1 year later. As compared with patients coming from institutions for permanent care, patients coming from their own homes had a significantly better prognosis in terms of survival, mobility and ability to cope with activities of daily living (ADL). However, patients returning home needed increased domestic help. Patients living with someone returned home sooner than those living alone. Although many of the patients who returned home could walk without support or with a walking-stick, more than one half did not go out shopping. More active measures, e.g. early home visits by a rehabilitation team, might give the patients more self-confidence and independence. Immediate weight-bearing did not appear to impair healing of the hip fracture or increase the risk of necrosis of the femoral head.

Activities of Daily Living↗

The epinephrine effect in renal angiography revisited.

The effect of various doses of epinephrine on the renal vessels was studied angiographically in 15 kidneys including three renal tumours. Commonly used doses (10--25 microgram) are often too high as demonstrated in this study. Our findings indicate that the optimal dose for pharmacoangiography of renal masses should be 2--5 microgram of epinephrine. The time interval between drug administration and angiography should be less than 1 min and optimally in the range of 10--30s.

Adult↗

Hypovascular renal tumors: an aggressive diagnostic approach required.

The value of a fine needle aspiration biopsy for confirmation of malignancy is demonstrated in 3 cases of angiographically hypovascular renal tumors. In 2 cases ultrasound examination suggested solid lesions but in 1 case it was predominantly sonolucent. Reliable documentation in the literature indicates that the risk of spreading tumor cells and, hence, of decreasing the survival rate is negligible.

Angiography↗

Angiography of the pancreas.

The diagnostic potentials of pancreatic angiography are discussed on the basis of four illustrative cases and a review of the pertinent literature. It is concluded that selective visceral angiography properly applied is of great value in diagnosing carcinoma of the pancreas and in determining resectability of pancreatic tumors.

Adult↗

Angiographic findings following surgical treatment for renovascular hypertension.

The authors present the postoperative angiographic appearance of the revascularized renal artery in 128 patients. The angiographic findings in four types of surgical procedures (saphenous bypass graft, dacron graft, endarterectomy, and reimplantation of the renal artery) are discussed. Postoperative angiography accurately demonstrates graft patency or occlusion.

Adolescent↗

Evaluation of solitary renal cystic lesions.

The diagnostic approach in cases of expanding renal lesions is reviewed on the basis of 106 patients with cystic lesions. Differential diagnostic aspects of cysts, tumor masses and cystic tumors are given. Ultrasound examination is considered to reduce the need of nephroangiography otherwise required. The value of nephroangiography with angiotensin in equivocal cases is emphasized.

Adult↗

Roentgenologic appearance of fibromuscular dysplasia.

Clinical and roentgenologic findings in 100 hypertensive patients with fibromuscular disease of the renal arteries are presented and compared with the experiences obtained from previously reported large series. Frequency of bilateral disease and abnormal findings at urography, involvement of segmental arteries and occurrence of extrarenal manifestations are reported. A striking female preponderance is noted, and there is evidence that the disease inflicts middle-aged rather than young women.

Adolescent↗

Morphologic sequelae to contrast medium deposits in the kidney. An experimental investigation in the rabbit.

Various doses of Pantopaque and Vascoray were injected percutaneously into the kidneys in 17 rabbits. Histologic examination of the kidneys at different time intervals following the injection demonstrated only slight injury to the renal parenchyma which could be related to the contrast media. Therefore, it seems reasonable to assume that the risk of causing renal damage by using Pantopaque in connection with renal cyst puncture is small.

Animals↗