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Biomedical subjects

L Durand

Publications and source records attributed to L Durand.

At least 91 records · Page 5Linked to original sources
PubMed1986

[En bloc excision in the conservative surgery of neoformations of the anterior uvea. Apropos of 2 cases of adenoma of the ciliary body].

Indications of enucleation for uveal tumors were systematic in the past. They should become more adapted actually. Anterior limited uveal tumors, as in our two personal observations, should be an indication to realize a preservative treatment of the eye; the authors recommend the "block-excision" method, which allows: first, the ablation of the whole tumor and consequently the best possible prognosis, then, an anatomopathologic study which confirms the clinical diagnosis and avoids performing excessive enucleation in case of benign tumors as adenoma.

Adenoma↗
PubMed1985

Delays in the primary vaccination of children.

The results of a population-based survey of 170 children's vaccination records were used to calculate the cumulative distributions of the ages (in months) at which each dose of vaccine had been received. Considerable delays in the administration of measles-mumps-rubella (MMR) vaccine and of the fourth dose of diphtheria-pertussis-tetanus vaccine were observed, particularly in children vaccinated by private physicians rather than at public health clinics. The delay before MMR vaccination causes concern because of the frequency of measles in children aged 1 to 2 years, particularly those attending day-care centres, and the fragility of the herd immunity against this disease. Physicians should follow up patients who have missed appointments for MMR vaccination if a voluntary measles control program is to succeed.

Age Factors↗
PubMed1985

[Focus on an anatomoclinical entity: Biber-Haab-Dimmer lattice dystrophy].

The present study tries to point out new ideas about lattice corneal dystrophy. From our own observations we distinguish five clinical stages corresponding to each decade of life. We discuss the pathogenesis of the disease and the new histochemical and microscopical methods, and we emphasize on surgical treatment. In fact, surgery must be performed late in life and penetrating keratoplasty has become the treatment of choice. However, some authors describe recurrence of clinical signs of the dystrophy in penetrating grafts. In our study of thirty patients (between 1974 and 1984) including histopathologic evidences (66 procedures including 40 penetrating and 26 lamellar keratoplasties), did not find any single case of recurrence after penetrating keratoplasty.

Adult↗
PubMed1984

[Role of prostatic acid phosphatases in the treatment of adenocarcinoma of the prostate].

On the basis of a series of 89 patients with a histologically confirmed adenocarcinoma of the prostate and another population of 89 patients with prostatic hypertrophy, also confirmed histologically, the authors study the sensitivity and specificity of the radio-immunological estimation of prostatic acid phosphatase levels. Comparison is made of the performance of radio-immunological techniques with that of conventional techniques. As a general rule, the sensitivity of the test is very low, since amongst 39% of the prostatic carcinomas studied, the RI acid phosphatase level was below the upper limit of normal fixed at 3.2 ng/ml. By contrast, the degree of specificity is high, since amongst 96% of cases with abnormally high RI acid phosphatase levels, the diagnosis was indeed an adenocarcinoma of the prostate. In terms of stages, sensitivity was found to be nil for minor stages T1 - T2 and of the order of 80% for advanced stages. This confirmed data from the literature. In the absence of bone metastases detectable radiologically or by isotope bone scan, an abnormally high RI acid phosphatase level is predictive of lymph node involvement in 90% of cases. By contrast, under the same conditions of bone investigations, a normal RI acid phosphatase level corresponds in 81% of cases with absence of lymph node involvement and in 19% with limited involvement. In patients with value which are normal or become normal under the influence of treatment, the prognosis is better than if such does not apply. Finally, figures given by radioimmunological estimation are much more specific than those obtained by traditional enzyme estimations.

Acid Phosphatase↗
PubMed1983

[Bladder tumors treated with radical cystectomy. Results of 78 cases].

UNLABELLED: The authors present the results of 78 radical cystectomies for bladder tumour, followed up for at least 3 years. All the patients received preoperative pelvic radiotherapy (in general a flash of 5 Gys). Urinary derivation was of transintestinal cutaneous ureterostomy type. Surgery was followed by additional radiotherapy of 50 Gys in 9 patients and chemotherapy (adriamycin, Vehem and cis-platinum) in 6. RESULTS: stages 0 and A - 100% survival; stage B - 74%; stage C - 29% and stage D - 30%. Amongst the patients dying as a result of their carcinoma, 25% stage B, 36% stage C and 20% stage D had local recurrences. With regard to the prevention of recurrences, heavy preoperative radiotherapy is not more effective than flash radiotherapy of 5 Gy. For stage D and C patients together, overall survival was 50% at 3 years. Four stage D patients appear to be cured at 3 years, i.e. 17% of the stage D cases. This proves the possibility of "cure" of stage D disease by extended excision and thorough lymph node dissection. Adjuvant chemotherapy may certainly play a role.

Adult↗