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Biomedical subjects

L Diakhate

Publications and source records attributed to L Diakhate.

At least 37 records · Page 2Linked to original sources
PubMed1999

[Association between Class I HLA alleles and HBs antigen carrier status among blood donors in Senegal].

The course of hepatitis B virus (HBV) infection may be influenced by the host immune response. A prospective study was carried out in ninety-eight subjects (mean age = 23 years) HBs antigens carriers of hepatitis B and living in Dakar, Senegal. We analysed the HLA-A, -B, and C antigens distribution compared to that one of a control (HBs negative) healthy senegalese population (n = 96) living in Dielmo village where a longitudinal study was set-up since 1990. The HLA class I typing was performed by microlymphocytotoxicity assays. The most frequent HLA-A, -B, -C antigens found were: locus A: A23 (33.6%), A2 (25%), A30 (25%), locus B: B8 (31%), B7 (16.3%), B58 (11.9%), B35 (11%), B49 (11%), B53 (10.8%) and locus C: Cw7 (39.1%), Cw17 (39.1%), Cw3 (36.9%), Cw4 (36.6%). Significant differences (P < 0.001) were found between the donors and the control group for the following HLA antigens: A1, A23, B8 and Cw3. The detection of HBe antigen was positive in 26/84 blood donors. It was observed a significant difference (p < 0.01) between positive and negative HBe donors for HLA-A1 allele with an odds ratio of 6.25. All the donors carrying the HLA haplotype: A1-B8-Cw7 (11.5%) were positive in HBe antigen. HLA: B8-Cw7 haplotype (detected in 8.5% of positive donors) seems to be likely associated with a liver cancer according to many reports. An adequate follow-up should be set-up for positive HBe subjects carrying a susceptible HLA type.

Adolescent↗
PubMed1997

Presenting features at diagnosis and complications of hemophilia in Dakar: apropos of 25 cases.

In order to describe the presenting features at diagnosis and complications of hemophilia in Dakar, we conducted a study of hospital records between October 1991 and January 1993. Twenty-five cases of hemophilia were identified. We found that only 4% of our patients were diagnosed in the first 6 months of life whereas 64% of patients were diagnosed between 6 months and 5 years of age, 32% were detected between 5 years and 14 years of age. The presenting feature at diagnosis was external bleeding in 60% of cases and internal bleeding in 40%. 92% of cases were hemophilia type A and only 8% hemophilia type B. 56% of patients had mild hemophilia, 40% moderate and only 4% severe disease. Hemophiliac arthropathy was present on radiography in 76%. Complications were dominated by repeated joint bleeding, which was present in 92% of patients, and repeated hematomas (80% of patients). A functional handicap was present in 60% of cases. 12% of transfused hemophiliacs developed an inhibitor and 4% of patients were HIV positive. Greater awareness of hemophilia amongst the medical community as well as continued efforts to improve care for hemophiliacs in Senegal are necessary.

Adolescent↗
PubMed1996

Epidemiology and therapy of malignant hemopathies in Senegal.

The objectives of this study were to determine the prevalence of malignant hemopathies among patients in Dakar hospital and to examine the current methods of treatment in Senegal. A retrospective analysis of patients diagnosed in Dakar hospitals from 1st January 1986 to 31st December 1992 revealed 210 cases of malignant hemopathies, but only 155 patient records were retrieved (73.8%). The prevalence of malignant hemopathies was 7/1000 and males were predominant with a sex ratio of 1.6 (p = 0.0001). Acute leukaemias (AL) appeared mainly in young people with a mean age of occurrence of 18.8 years, while immunoproliferative syndromes (IS) and myeloproliferative syndromes (MS) were mostly found in adults with respective mean ages of occurrence of 38.9 and 38.7 years (p = 0.000004 AL vs IS, p = 0.00001 AL vs MS). Concerning therapy, 14.2% of patients died without treatment and 26.1% received only symptomatic treatment. Chemotherapy was employed in 61% of cases, complete remission being obtained in 20.6% of these patients but of no remission in the remaining 79.4%. Mean survival was 2 months for AL, 5 months for IS and 6 months for MS. Close collaboration between haematologists and clinicians and creation of a specialized clinical haematology department will be necessary to overcome current difficulties in the treatment of these affections.

Adult↗
PubMed1994

Quantification of T cells reactive to Pf155/RESA peptides in Plasmodium falciparum-exposed individuals.

This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to Plasmodium falciparum antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites: either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, "saw-tooth curves" were obtained, suggesting the existence of suppressor mechanisms operating in vitro in our limiting dilution assay.

Adult↗
PubMed1992

[Antithrombin ii in eclampsia: estimation of predictive value].

We have observed in our study that antithrombin III activity decreases very significatively in eclampsia (p < 0.0001). A level of 90% was defined as a threshold. All the rates which are under or equal to 90% have 78.3% as a positive predictive value and those over 90% have a 98.7% as a negative predictive value for the overcoming of eclampsia. We have concluded that the 90% antithrombin III activity represents the alarm level for over coming eclamptic crises. The determination of the antithrombin III activity must be systematically done in every hypertensive pregnancy with proteinuria.

Adult↗
PubMed1990

[In vitro effects of Fagaro xanthoxyloïdes Lam. on drepanocytic erythrocytes].

Study of the effect of acquious extract of Fagara xanthoxyloids Lam on the red blood corpuscles of 17 drepanocytics (SS) and 3 carriers of the trait (AS) showed drepanocyte reversibility with a residual level of 7%, an increase in the haemoglobin jellification time to 25 mn. 15 sec. (as compared to 9 mn. 57 sec.) and a shortening of red corpuscle filtration time from the normal 24.65 sec. to 9.6 sec. In a way as yet not understood, Fagara, like pentoxiphyllin, improves the rheological properties of drepanocytary blood.

Adolescent↗
PubMed1990

[Antithrombin III in the Senegalese diabetic].

The chronometric method was applied to 141 diabetics and 151 reference subjects from both sexes aged between 19 and 60 years, all of Black race and Senegalese nationality, to study the effects of Antithrombin III (AT III). A significant reduction in the physiological activity of antithrombin III (AT III) was observed for ages 36-45 and 56-60 and correlated with obesity and other complications. With our patients, insulin dependence does not seem provoke any reduction in antithrombin III's effectiveness.

Adult↗
PubMed1989

RH polymorphism in the Senegalese population.

RH polymorphism was evaluated in Senegalese ethnic groups: Ouolof, Serere, Toucouleur, Peul, Diola and Mande. The cDe frequency was high, the cde frequency varied between groups and the cDE frequency was twice as high as the CDe frequency. No significant heterogeneity could be assessed between tribes. Nevertheless, cluster analysis disclosed the same pattern in Diola, Toucouleur and Ouolof, while the Peul were intermediary between these and the Serere and the Mande.

Ethnicity↗
PubMed1989

[CD4+ and CD8+ lymphocyte subpopulations in bone marrow deficiency anemias].

The study of CD4-CD8 lymphocytary sub-populations in 13 anaemic patients led the authors to note an increase in the CD8+ population in 61.5% of the cases, which resulted in the inversion of their CD4/CD8 ratio. This increase in the CD8 sub-population is connected with marrow-deficient anaemia, which leads them to suggest that marrow-deficient anaemia could well be classified according to the lymphocytary sub-populations.

Anemia↗
PubMed1985

Lack of perinatal transmission of hepatitis B virus infection in Senegal, West Africa.

Between 1977 and 1980, 1442 pregnant women in Thies, Senegal, were tested for serologic markers of hepatitis B virus (HBV) infection. Of these, 9.8% were HBsAg(+), 59.9% were anti-HBs(+), and 15.6% had anti-HBc alone. Of 116 HBsAg(+) pregnant women, only 19.8% were HBeAg(+), a much lower proportion of infectious carriers than seen in Asian populations. Cord blood from 1353 babies was HBsAg(-), implying that the babies were not infected prior to birth. Four hundred sixty-two babies, including 88 born to HBsAg(+) mothers, were observed for 2 weeks to 38 months after birth. In contrast to observations in Asia, none of the babies became HBsAg(+) before 5 months of age, and only three of the 16 born to HBeAg(+) mothers became HBsAg(+) within the first year of life; all three developed chronic infections (i.e., HBsAg(+) for greater than or equal to 6 months. In the second year of life, six of 34 babies born to HBsAg(+), HBeAg(-)/anti-HBe(-) mothers became infected with HBV, and four of the six developed chronic infections. During the first 3 years of life, infections occurred at a higher rate in infants born to HBsAg(+) (17%) than to HBsAg(-) (4%) women. The latter group of infants included 4.0% of those born to anti-HBs(+) mothers, 4.6% born to anti-HBcAg(+), and 3.2% born to uninfected women. These observations indicate that HBV infections in Senegal usually do not occur perinatally, but do occur at high incidence later in infancy and childhood. Such infections can be prevented by the use of hepatitis B vaccine alone; administration of hepatitis B immune globulin should not be needed.

Child, Preschool↗
PubMed1985

Antibodies to HTLV-I p24 in African and Portuguese populations.

Using a radioimmunoassay to detect HTLV-I protein antibodies of molecular weight 24,000, we screened populations from Algeria (140 subjects), Tunisia (442), Mali (69), Senegal (415), Uganda (135), the Central African Republic (77), the Congo (360), and Madagascar (193). Only four subjects were positive (1 from Senegal, 1 from Uganda, 2 from the Congo). This is a much lower figure than that found by others in Africa by the enzyme-linked immunosorbent assay technique. In addition, 319 Portuguese blood donors (46 of whom have lived in Angola or Mozambique) were screened using the same radioimmunoassay. All were negative.

Adolescent↗