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Biomedical subjects

L Bossi

Publications and source records attributed to L Bossi.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Changes in primidone/phenobarbitone ratio during pregnancy and the puerperium.

Plasma concentrations of primidone and its metabolite phenobarbitone were monitored in 9 pregnant epileptic patients treated with primidone (and in 3 cases other antiepileptic drugs) given at constant doses throughout pregnancy and the puerperium. Phenobarbitone plasma concentrations were monitored in another 6 patients given phenobarbitone itself. A trend towards increasing primidone plasma concentrations during the second quarter of pregnancy was evident in all patients, with a concomitant significant decrease in primidone-derived phenobarbitone plasma concentrations. A trend towards a lowering of plasma concentrations of phenobarbitone administered as such was confirmed. These results suggest the usefulness of a careful monitoring of primidone and primadone-derived phenobarbitone during pregnancy and the puerperium. Discrepancies of findings with primidone and phenobarbitone are discussed in view of the possible mechanism involved.

Adolescent↗
PubMedDate not supplied

Plasma concentrations of carbamazepine and carbamazepine 10,11-epoxide during pregnancy and after delivery.

Plasma concentrations of carbamazepine were monitored in 9 pregnant epileptic patients treated with the drug alone at constant doses during pregnancy and for at least 3 months after delivery. In addition, plasma concentrations of the metabolite, carbamazepine 10,11-epoxide were measured in 6 of the 9 patients. Plasma carbamazepine concentrations were fairly stable during pregnancy, and carbamazepine relative plasma clearances were significantly higher in weeks 4 to 24 than in weeks 25 to 32. After the end of the second trimester, there were no variations in plasma carbamazepine 10,11-epoxide concentrations and carbamazepine 10,11-epoxide:carbamazepine ratios. Both parameters were significantly higher in weeks 4 to 24 than in weeks 25 to 32 of pregnancy.

Adult↗
PubMedDate not supplied

Algodystrophy: treatment.

Treatment of reflex sympathetic dystrophies involves early reduction of the nociceptive input, transient interruption of the sympathetic activity, modulation of central mechanisms of pain control, prevention of neurotrophic changes and treatment of associated behavioural problems. The fundamental steps are early control of pain by means of local anesthetic blocks and antiinflammatory agents followed by sympathetic blocks, physical therapy, transcutaneous electrical stimulation and supportive psychotherapy. The results obtained are not always satisfactory and about 40% of the patients is not susceptible to cure. The best results are obtained when treatment is started early.

Autonomic Nerve Block↗
PubMedDate not supplied

[Dyskinetic-athetosic syndrome in a patient with prior radiculo-myelo-encephalopathy of probable viral origin. Therapeutic guidelines with levodopa and preliminary results].

The regulation of skeletal muscle tone and of the automatic and half-automatic movements by the extrapyramidal system in briefly discussed. The essential importance to keep separated the akinetic-hypertonic syndromes from the hypotonic-hyperkinetic ones is further confirmed. In fact two different chemical mediating agents work separately in these two cases: the Dopamine for the Nigro-Striatal system and the Ach for other tracts whose anatomy is still not well known, but which surely belong to the extrapyramidal system. Further more a clinical case of dyskinetic-athetosic post-infective syndrome, successfully treated with L.D., is discussed. The effectiveness of neuroleptic drugs in these hypotonic-hyperkinetic syndrome is stressed while they cause and worsen extra-pyramidal symptoms such as hypertonia and akynesia (hypertonic akinetic s.).

Athetosis↗