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Biomedical subjects

L Bonomo

Publications and source records attributed to L Bonomo.

At least 343 records · Page 19Linked to original sources
PubMedDate not supplied

[Congenital hip dislocation. The clinico-echographic correlations].

The authors report their experience with US of the hip in 200 children aged 9 days to 8 months. All the children previously were under-gone physical examination. The sonographic study was carried out with Graf's method. The clinical-sonographic correlation proves the utility of US as a screening method able to show early morphological and functional alterations in the hip. US is thus suggested as a valid alternative to conventional methods to use in those cases where either plastering or surgery is required.

Female↗
PubMedDate not supplied

[Radiological examination of the thorax in intensive therapy centers].

Bedside chest radiography plays a considerable role in the whole of the exams carried out in hospitals, especially in intensive care units. Many clinical problems (pulmonary, cardiac, and mediastinal) are related to this examination and can be dealt with only when the radiologist is provided with high-quality radiographs. Therefore, it is extremely important for the radiologist himself to be aware of the various factors implied in the making and reproducing of bedside chest radiographs, which is a fundamental step in the monitoring of the patients undergoing intensive care. These factors can be divided into methodological factors (patient positioning, focus-film distance, and exposure) and technical factors (portable units, survey system). In this paper, a special emphasis is put on a survey system consisting in double differentiated screens and double film, which allows the acquisition of a normo-exposed radiograph of the parenchyma and of one of the mediastinum with a single exposure. Besides these technical and methodological elements, the radiologist must pay attention to the diagnostic-therapeutical means (such as tubes, small probes, and catheters) used on most patients in intensive care units. Their exact positioning must always be checked, and possible incorrect positioning and complications must be detected promptly. All these factors, as well as their scrupulous and constant application, contribute to markedly improve the dialogue between clinician and radiologist, by allowing a rapid evaluation of the cause of the clinical case under examination and its adequate treatment.

Humans↗
PubMedDate not supplied

[Clinical course and phenotypic instability in 4 cases of multiple myeloma: a biological model of tumors].

Four cases of multiple myeloma (MM) are reported in which the coexistence and/or the alternance of different plasma cell clones were observed. Genetic instability is typical of all tumors but in MM it is particularly striking due to the M component marker. In this respect, malignancies reveal the presence of an unremitting competition of different cell populations for the phenotype prevalence. When this phenomenon is related to the clinical picture it is possible, as in our cases, to ascertain that the appearance of new clones often corresponds to significant changes in the disease evolution.

Aged↗
PubMedDate not supplied

Correlation of duplex scanning and two plane angiography in patients with symptomatic carotid stenosis.

The correlation between flow velocity and percent stenosis in carotid arteries was assessed in 43 symptomatic patients (86 carotids) using duplex scanning and angiography. Duplex scanning evaluation was performed using the ATL Ultramark 4 duplex scanner with the 5-7.5-10 MHz probe. Using the ratio of peak velocity in the internal carotid in systole (VICA) to the end diastolic velocity in the common carotid (VCCA) we studied its correlation with the percent stenosis observed by angiography. A good correlation (r = .95) was found. The graph obtained indicates that a significant (greater than 50%) stenosis may be graded by the VICA/VCCA ratio with a high degree of accuracy (97%). This may be useful not only for screening patients to select for angiography and surgery but also to follow up the natural history of carotid stenosis.

Angiography↗
PubMedDate not supplied

Immune function in patients with multiple myeloma (delayed cutaneous reactivity and lymphocytes bearing receptors for sheep, human and mouse erythrocytes).

Immunologic function was evaluated in 27 patients with multiple myleoma (MM). When tested for their ability to develop delayed hypersensitivity to panel of skin test antigens, 2 out of 15 such patients were found to be anergic. The property of human peripheral blood T lymphocytes to form rosettes with sheep [total E and active or early rosette-formimg cells (RFC)] and human erythrocytes (H-RFC) was also studied. In addition, rosette formation with mouse erythrocytes (M-RFC) was investigated as a B cell marker. Decreased proportions of total E-RFC were found in one third of the patients with MM when compared to normal volunteers. By contrast, both mean percentages and ranges of active E-RFC, H-RFC, and M-RFC in the MM patients overlapped those revealed in healthy controls. The rosette-forming ability of peripheral blood lymphocytes was tested before and after treatment with levamisole, thymosin, and transfer factor in healthy controls, as well as in some groups of patients with MM active systemic lupus erythematosus and Hodgkin's disease. A positive effect of all three immunomodulating agents could only be demonstrated on cells from T cell-deficient patients. It is suggested that the immunodeficiency syndrome associated with MM and related malignancies may reflect quantitative and possibly selective defects of lymphocyte subpopulations.

Animals↗