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Biomedical subjects

L Bergmann

Publications and source records attributed to L Bergmann.

At least 163 records · Page 9Linked to original sources
PubMed1982

[Sequential chemotherapy of malignant non-Hodgkin's lymphoma of high degree of malignancy in stages III and IV].

A sequential combination chemotherapy was used in the treatment of advanced high-grade malignant non-Hodgkins' lymphomas (NHL) from July 1978 to August 1980. The lymphomas were classified according to the Kiel-classification. Cyclophosphamide, vincristine, bleomycin, prednisone (phase A) were followed by a combination of adriamycin, cytosine arabinoside, 6-thioguanine and prednisone (phase B). Patients received four cycles of both combinations. No maintenance therapy was given. 20 patients with centroblastic, lymphoblastic or immunoblastic NHL were included in the study. The overall remission rate was 95% (19 out of 20 patients). 15 (75%) patients entered complete remission. The median duration of complete remission was 28.7 months. The probable survival rate of the patients entering complete remission is 64.5% at two years. Clinical prognostic factors, bone marrow infiltration, extralymphatic organ involvement other than skin and a tumor mass greater than 10 cm in diameter in a single location significantly affected remission induction and survival. All patients with favourable prognosis are still alive in unmaintained complete remission 14 to 38 months after start of treatment. Patients with unfavourable prognosis had a complete response rate of 64% and a median survival of 14.8 months.

Adult↗
PubMed1982

[Is there a relation between occupational exposure of the welder and the formation of bronchial cancer?].

From 1961 to 1979 844 men with a bronchogenic carcinoma have been operated in the Pulmological Department of the Wittenberg-Apollensdorf hospital. 63 patients (7.5%) were younger than 45, 781 (92.5%) were older than 45 years of age. Those who are employed in the metal industry are at the top of the occupational index in both age groups, whereas those employed in the chemical industry are only on place 5, although the district of Halle from which the patients mostly are coming is the centre of the chemical industry in the GDR. In our investigations it is remarkable that the group of welders, and heating fitters is to be found on place 2 among the younger patients, whereas the older ones occupy place 11.

Adult↗
PubMed1981

Surface IgM kappa of prolymphocytic leukaemia cells with antibody activity to surface antigens of sheep and guinea-pig red blood cells.

The immunological findings of a B-cell prolymphocytic leukaemia forming spontaneous rosettes with sheep (SRBC) and guinea-pig red blood cells (GPRBC) are reported. The B-cell lineage was revealed by Ia-like antigen, surface IgM kappa and lack of cytotoxicity of anti-human T-cell serum. Despite B-cell characteristics, prolymphocytes formed spontaneous rosettes with SRBC. Inhibition procedures demonstrated rosette formation to be the result of antibody activity of surface IGM to SRBC and GPRBC. Pretreatment of prolymphocytes with pronase or antibodies to mu or kappa-chains inhibited rosette formation. Furthermore, pre-treatment of SRBC with the patient's serum or IgM decreased rosette formation demonstrating circulating antibodies to antigen(s) of SRBC. Antigen(s) on SRBC and GPRBC are not related to Forssman or Paul Bunnel antigen.

Antigens, Surface↗
PubMed1981

Clinical studies on multiple sclerosis. I. Presentation of an incidence material from Gothenburg.

Probable and possible MS cases with a debut during the years 1950-1964 within the city of Gothenburg were identified (312 cases). This corresponds to an incidence of 5.3 per 100,000. The material was stratified according to diagnostic probability into three categories. For the final analysis cases with the lowest diagnostic probability were omitted (about 9%). The follow-up was completed during 1977, i.e. 13-27 years from onset. A longitudinal analysis of each case was based upon a mixed prospective/retrospective study in which the authors personally examined the majority of the cases during most of the years. The female/male ratio was 1.5-1.6. The mortality rate was higher for males due in part to an earlier progressive development of multiple sclerosis and in part to a higher trend for acquisition of other mortal diseases. Bouts, as the first manifestation of the disease, were more frequent in young ages than in old, and more frequent among females than in males. The averages bout frequency decreased significantly with the duration of the disease as well as with the age of onset. The opposite trend was characteristic for development of a progressive course. Among symptoms at onset, those indicating lesions of long sensory and/or motor tracts (particularly the sensory) dominated. Such initial symptoms were seen in 30-40% of the younger patients and 70% of the older patients. The rest was divided between cases with optic nerve lesions (20-30% among younger, 12-15% among older patients) and brain stem lesions (approx. 25% among younger, 10-19% among older patients). The occurrence of various symptoms during the first two decades of the disease was also analyzed and the pattern of symptoms presented graphically. These results will be treated further in subsequent studies.

Adolescent↗
PubMed1979

[Studies of a full night's sleep in patients with absences].

Clinical electro-encephalography and especially the simultaneous recording of EEG values and other physiological parameters can greatly contribute to investigations into the neurophysiological aspects of sleep disturbances in patients suffering from attacks. In the case of absences peak potentials have been found in all phases of sleep, with a reduction in the pattern-like arrangement of the peak potentials and an increase in the irregular spike-and-wave complexes. During the dream phase, however, the peak potentials of these patients were primarily in the form of "patterns" comparable to the situation when they were awake. This evidence of epileptic activity throughout all sleep phases of patients suffering from absences makes it necessary to give anticonvulsive drugs in three doses distributed evenly over the entire day.

Child↗
PubMed1979

[Subclavian steal syndrome in childhood (author's transl)].

The authors report on four children with subclavian steal associated with coarctation or interrupted aortic arch. All children showed a stenotic origin of the left subclavian; in addition three of them had an extreme hypoplasia of the proximal segment of this artery. Two children had typical symptoms of insufficiency of the vertebral and basilar circulation (headache, dizziness, syncopal attacks, vision and hearing disorders) since the age of 7 and 8 years, respectively. The clinical findings, such as reduced pulses and blood pressure of the respective arm, may suggest the provisional diagnosis. The principles of congenital subclavian steal are discussed.

Aortic Arch Syndromes↗
PubMed1976

[Stages of development of aspergillus-mycetom and their roentgenographic signs (author's transl)].

A series of 13 cases of aspergillus-infection in the respiratory tract are reviewed. A case of rapid development of an intrapleural aspergillus-mycetom is presented. A complete series of chest roentgenograms and operation-photos allowed to demonstrate like with a quick-motion apparatus 3 stages of development of an intrapleural aspergillus-myceton: I. Infection through Aspergilli of a residual intrapleural cavity by the bronchial way. Pleural thickening as reaction to the irritation. II. Development of fungus-lawn and mycotic layers on the cavity-wall. III. Scaling off from the wall and moulding to the fungus-ball through movement of human body. Each of the three stages can be coordinated to a roentgenographic sign. The detection in an early stage of development makes it possible to treat the aspergillus-mycetom also by conservative methods, f. i. with a Pimafucin-Suspension (Natamycin) by aerososl.

Adult↗