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Biomedical subjects

L Bergmann

Publications and source records attributed to L Bergmann.

At least 145 records · Page 8Linked to original sources
PubMed1984

[Clinical aspects and observations on patients with lymphadenopathy syndrome].

Since November 1982, patients with symptoms suggesting a lymphadenopathy syndrome (LAS) or acquired immune deficiency syndrome (AIDS), as well as their contacts and persons in high risk groups were examined as out-patients. The examinations have now been concluded in 101 patients. The patients were divided into 3 groups according to clinical symptoms and the OKT4+/OKT8+ ratio: 30 patients with normal ratio (group I), 59 patients with LAS and a ratio of less than 1 (group II) and 12 patients with fully developed AIDS (group III). During a follow-up time of 18 months, 3 patients of group I developed LAS and 1 patient in group II developed toxoplasma encephalitis. In a further 2 patients with LAS, uncharacteristic symptoms such as fever, tiredness and loss of weight increased, while at the same time the number of OKT4+ cells and thus the ratio fell significantly. In 4 cases the immunological parameters and the clinical picture improved. In 52 patients the clinical picture and the laboratory findings did not change. The demonstration of retrovirus HTLV III would seem to provide the cause of LAS and AIDS. Nonetheless, follow-up observation of contacts and patients with LAS remain important.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Imbalances of T-cell subsets in monoclonal gammopathies.

In 42 patients with untreated or treated multiple myeloma (MM) or benign monoclonal gammopathy (BMG) the lymphocytes and T lymphocyte subsets were determined by monoclonal antibodies and other surface markers. In untreated MM, the T cells (1077/microliters vs 1439/microliters, P less than 0.01) and especially the OKT4+ lymphocytes (700/microliters vs 950/microliters, P less than 0.05) were significantly reduced compared with a control group. The OKT8+ cells were slightly but not significantly decreased. In previously treated MM, the loss of T cells was more pronounced than in the untreated group and was primarily caused by a further reduction of OKT4+ cells. Patients with BMG revealed decreased OKT8+ lymphocytes (304/microliters vs 502/microliters, P less than 0.001), whereas the OKT4+ cells were within the normal range. Therefore, the OKT4/OKT8 ratio was significantly elevated compared with that in untreated MM patients and normal controls (3.31 vs 2.06 vs 2.13; P less than 0.005). To sum up, in MM the results revealed a reduction of T cells, mainly of OKT4+ cells, which is intensified by chemotherapy and persists even after a long therapy-free interval. The different findings of T cell subsets in BMG and MM may be a helpful criterion to differentiate between BMG and MM.

Antibodies, Monoclonal↗
PubMed1984

High-dose adriamycin (ADM) and cis-platinum (DDP) in advanced soft-tissue sarcomas and invasive thymomas. A pilot study.

Eighteen previously untreated patients with advanced unresectable or metastatic soft-tissue sarcomas (STS) and two patients with locally invasive thymoma were treated with a combination of adriamycin (ADM) 80 mg/m2 on day 1 and cis-platinum (DDP) 120 mg/m2 on day 1. The regimen was repeated at 4-weeks intervals. In STS the overall remission rate was 44%, with 21% complete remissions. The overall survival was 15 months (3-35+), responders surviving a median of 20 months (3-35+) and nonresponders, a median of 9 months (3-20+). Tumor responses lasted a median of 8 months (3-35+). Two patients with liposarcoma have now survived disease-free for at least 2 years and are potentially cured. The two patients with thymoma experienced complete remission lasting 4+ and 20+ months. Substantial hematologic toxicity was prominent, due to the high-doses used in this combination regimen.

Adult↗
PubMed1984

[Fatigue fractures of the 1st rib and their combination with spontaneous pneumothorax].

The pathogenesis and the causal atraumatic mechanism of uni- and bilateral stress fractures of the first rib in 4 cases of young men will be discussed. In 3 cases the discovery of these fractures has been the result of mass x-ray survey alone without complaints by the patients. As a causal factor there must be supposed a permanent strain and (or) an overstrain of the mm. scaleni. At a 15-year-old schoolboy we found a combination of bilateral fracture of the first rib and bilateral spontaneous pneumothorax. In this case we suppose that an overstrain of the mm. scaleni medius and anterior is responsible for the fractures of the rib, and an abrupt distension of the pleural cupola by the m. scalenus minimus - occurring among 72% of all European children - for spontaneous pneumothorax. Minimal subpleural emphysematous bullae adherent to the pleural cupola might be ruptured by this distension. This mechanism is probably also responsible for other cases of spontaneous pneumothorax, in which no stronger physical strains of the patient were preceding.

Adolescent↗
PubMed1983

[Prognosis in children with infantile seizures and possible factors influencing it].

Different developments (good n = 8, poor n = 15 and very poor n = 27) in 50 former patients with infantile myoclonic seizures are compared with findings from the acute phase of the disease after 11.1 +/- 4.1 years. It has been confirmed that it is sensible with regard to intellectual development to distinguish idiopathic (very seldom) and symptomatic cases in infantile myoclonic seizures. An early beginning of the disease, developmental backwardness as well as pathological and neurological findings as signs of a cerebral damage or disease (symptomatic cases) suggest a poor prognosis.

Adolescent↗
PubMed1983

[Prognosis in primarily pure absence epilepsy].

17 patients out of a total of 93 treated for primarily pure absence-epilepsy experienced secondary grand mal-seizures and eeg of 8 patients showed a grand mal-disposition (irregular s-w). These 25 patients, compared with the remaining 68 patients, attended more frequently a special school for mentally retarded children, their marks were worse, they left school in a lower form, and their vocational education was less qualified. 8 patients out of 65, who were primarily treated with Suxilep and without additional grand mal-remedy, experienced secondary grand mal-seizures (relative frequency 0.12). The question of the necessity of primary grand mal-prophylaxis is beeing discussed.

Achievement↗
PubMed1982

[Induction of complete remission with adriamycin and cis-platinum in invasive thymoma].

Complete clinical remission was achieved in a very large lymphocytic thymoma with infiltration of both lungs and almost complete atelectasis of the left lung as well as superior vena cava syndrome using adriamycin (80 mg/m2, day 1) and cis-platinum (120 mg/m2, day 1). A dramatic reduction of tumour size was noticed already after the first cycle of chemotherapy. Remission still persists nine months after commencement of treatment.

Adult↗
PubMed1982

Expression of Ia-like antigen in lymphatic leukaemias and non-hodgkin lymphomas in correlation with other surface markers.

Ia-like antigen, surface Ig, E-rosettes, mouse red blood cell rosettes and further surface markers were investigated in 88 specimens from 69 patients with various lymphocytic leukaemias and non-Hodgkin lymphomas. Ia-like antigen was detectable in all cases of sIg+ leukaemias and lymphomas. E-Ia+sIg-leukaemias, especially CLL and lymphomas were interpreted as B-cell neoplasias, which either did not produce sIg or expressed it in undetectable amounts. E+Ia+sIg+ malignant lymphocytes represented a B-cell population with antibody activity of sIg to SRBC. In the present series 9.5% of all B-cell leukaemias and lymphomas demonstrated this phenotype. Whereas ALL may possess Ia-like antigen, the vast majority of mature T-cell lymphomas are lacking it. In the present series 2 T-cell lymphomas expressed Ia-like antigen and did not contain TdT (E+Ia+sIg-TdT-). These lymphomas are probably derived from a stimulated T-cell clone synthesizing Ia-like antigen.

Animals↗