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Biomedical subjects

L Babiuch

Publications and source records attributed to L Babiuch.

At least 19 recordsLinked to original sources
PubMed1992

Plasma protein C as a marker of hepatocellular damage in alcoholic liver disease.

The synthesis of a number of clotting factors takes place in a hepatocyte. Therefore, measurement of these factors in the blood have proved to be of additional value in the diagnosis and follow-up of liver diseases. In the present study we evaluated protein C level in the plasma of patients with liver cell damage due to chronic alcohol consumption. A decrease in plasma protein C concentration which correlated with clinical performance of the patients was found. Significant correlations between the level of protein C and antithrombin III, one-stage prothrombin time, factors VII and X and some biochemical tests reflecting liver cell damage were also stated. The obtained data indicate that plasma protein C level may constitute a useful marker of hepatocellular disease in alcoholics.

Adult↗
PubMed1992

[N-acetyl-beta-D-glucosaminidase and diurnal excretion of hydroxyproline in chronic viral hepatitis].

In 37 patients with chronic active hepatitis, in 14 with chronic persistent hepatitis and in 11 with normal histological pattern of the liver the serum activity of N-acetyl-beta-glucosaminidase and the 24-hour excretion of hydroxyproline with urine were determined. The 24-hour excretion of hydroxyproline was similar in all groups of patients, while the activity hepatitis and higher than in those of chronic persistent hepatitis (36.9 +/- 12.9 i.u. per 100 ml versus 22.4 +/- 8.2 i.u. per 100 ml, p less than 0.05). In patients with high serum NAGL activity cirrhosis developed significantly more frequently.

Acetylglucosaminidase↗
PubMed1991

[Infections with hepatitis B, C and delta viruses in patients with AIDS].

To analyse the prevalence of liver viral infections we tested sera of drug abusers HIV+ (23 persons), sera of drug abusers HIV--(30 persons) and sera of homosexuals HIV+ (18 persons). We looked for antigens delta and antibodies anti-HBcoreAg, anti-HCV, anti-HDV. Results showed the prevalence of HBV infections among drug abusers (in Warsaw) and lower prevalence of HBV infections among homosexuals. We did not find any HCV and HDV infection among tested homosexuals.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[T4 lymphocytes (helper cells) and T8 lymphocytes (cytotoxic and suppressor cells) in patients with asymptomatic and symptomatic HIV infection].

250 determinations of lymphocyte T subsets in 130 HIV infected patients (79 asymptomatic carriers or with lymphadenopathy, 31 ARC- and 20 AIDS-patients) were analyzed as to the percentage, number, and ratio of T4 (helper) and T8 (cytotoxic/suppressor) lymphocytes in sequential clinical stages of HIV infection. Asymptomatic HIV carriers or patients with lymphadenopathy were found to have statistically significant higher counts of erythrocytes, platelets, total lymphocytes, percentage and number of T4 lymphocytes and T4/T8 lymphocyte ratio than the ARC-patients. Persons with ARC in comparison with AIDS-patients were found to have significantly higher values of erythrocytes, platelets, leucocytes, total lymphocytes, T4 lymphocytes, percentage and count of T8 lymphocytes and T4/T8 lymphocyte ratio. In AIDS patients a statistically significant correlation was seen between number of T4 lymphocyte and number of erythrocytes, platelets, total number of lymphocytes and value of T4/T8 lymphocyte ratio.

AIDS-Related Complex↗
PubMed1991

[Prospective studies of T4 and T8 lymphocyte subpopulations and beta 2-microglobulin in patients with HIV infection].

Sequential changes of percentage and number of T4 (helper) and T8 (cytotoxic/suppressor) lymphocyte subsets and serum beta 2 microglobulin (beta 2m) level were observed in 23 HIV infected patients for a period of 4 months to 3 years. 10 subjects were asymptomatic HIV carriers, 9 had already AIDS at the beginning of the study and 4 patients developed clinically overt disease during the observation period. T4 lymphocyte number remained in normal range in asymptomatic HIV carriers but in 4 patients its decrease preceded the development of clinical symptoms of infection. A rapid decrease of T4 lymphocyte number was generally observed in AIDS patients. Serum concentration of beta 2m remained at relatively low and constant level in asymptomatic HIV carriers but in 4 cases its increase preceded the appearance of clinical symptoms. In patients with clinically overt disease beta 2m levels were significantly increased and reached the highest values just before death. A correlation between clinical stage of infection and the number of T4 lymphocytes and beta 2 m level was found.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[Influence of therapy with glucocorticosteroids on clinical status, t4 lymphocyte count and t4/t8 lymphocyte ratio in people infected with AIDS].

The influence of glucocorticosteroids (GKS) therapy on clinical status, T4 lymphocyte count in peripheral blood and T4/T8 lymphocyte ratio was investigated in five HIV infected patients: two were asymptomatic, while three had clinically overt disease. The reasons for GKS therapy were: thrombocytopenia in two patients, pancytopenia in two and sepsis with severe endocarditis in one. No influence of GKS on the clinical course of HIV infection was observed. The prospective determinations of T4 lymphocyte count and T4/T8 lymphocyte ratio were relatively constant in two cases, in one case increased and in two patients, one of whom had AIDS, a decrease in both parameters was observed. It seems that GKS therapy does not seriously influence the course of HIV infection in most patients and can be instituted without risk of severe worsening of the immune status.

Adrenal Cortex Hormones↗
PubMed1991

[Occurrence of HIV antigens in patients with acquired immunodeficiency syndrome].

A total of 74 serum samples from 37 AIDS patients were analysed for HIV antigen and results were correlated with duration of the disease, predominant symptoms, T4 lymphocyte count in peripheral blood, and antiviral therapy. The prevalence of HIV-Ag increased with duration of AIDS and T4 lymphocyte depletion. It was also higher in patients who were not treated with antiviral therapy than in treated persons. No correlation was found between HIV-Ag and clinical picture of AIDS. HIV antigenemia indicates a poor prognosis and can be regarded as an additional parameter of monitoring of AIDS patients.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[Titer of anti-P24 and anti-GP41 antibodies as a diagnostic parameter in patients with asymptomatic and symptomatic HIV infections].

Anti-p24 and anti-gp41 antibody titers were determined in sera from 20 asymptomatic HIV carriers and 15 AIDS patients. Anti-p24 titer was found to be significantly lower in AIDS patients than in asymptomatic HIV carriers and anti-gp41 titer was similar in both investigated groups. A correlation was found between T4/T8 lymphocyte ratio and anti-p24 antibody titer in patients with AIDS.

AIDS Serodiagnosis↗
PubMed1991

[Central nervous system (CNS) in patients with AIDS].

We had analysed central nervous system disorders in 30 AIDS patients with neurological signs and symptoms. 17 out of them (56.7%) showed abnormal EEG where CT scan revealed organic changes in 13/17 of them. Moreover, autopsy showed macroscopic and or microscopic changes of CNS in 13 out of 15 (86, 67%) cases.

AIDS Dementia Complex↗
PubMed1991

[AIDS and tuberculosis].

From Jan. 1, 1989, through July, 1, 1991, 193 patients with HIV infection were treated at the Department of Acquired Immunodeficiency, Infectious diseases Hospital in Warsaw. Tuberculosis was diagnosed in 11 (5.7%) cases; in three cases diagnosis was first established post mortem. In eight cases tuberculosis was diagnosed clinically and confirm by microbiologic or histologic examinations. Antituberculous chemotherapy was successful in five cases (early results). All 11 patients had other concomitant infections or neoplasms. Six of 11 patients died, of them 3 with misdiagnosis of tuberculosis prior to death. The problem of HIV infection and tuberculosis and its impact on epidemiology of tuberculosis is discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Affinity of anti-HIV antibodies in patients with asymptomatic and symptomatic HIV infection.

A novel method based on the dose-response curve of antibodies was used for the assessment of the affinity of anti-HIV antibodies in 15 males with asymptomatic or symptomatic HIV infection. The subjects were followed up for a period of 1 to 5 years. No significant correlation between antibody affinity and the clinical stage of infection was observed, however, the computed affinity values increased slightly in most of the asymptomatic HIV carriers and remained relatively constant in AIDS patients. A distinct decrease of anti-HIV affinity was observed in 2 patients with advanced AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[Serological markers of hepatitis b and hepatitis d among individuals with symptomatic and asymptomatic HIV infection].

Serological markers of present or past HBV infection were looked for in 69 persons infected with HIV. 40 out of them were clinically asymptomatic, while 29 showed evidence of clinically overt disease related to HIV infection. Most of them were homo- or bisexual men, prostitutes or intravenous drug abusers. Control group consisted of 247 anti-HIV negative persons with the same behavioural patterns. Serological markers compatible with present or past HBV infection were found in 18 out of 40 (45%) asymptomatic HIV carriers, in 23 out of 29 (79.3%) patients with clinically overt HIV infection, and in 82 out of 247 (33.2%) anti-HIV negative persons from the control group. Presented data show that HIV-infected clinically overt individuals have a higher prevalence of HBV markers than asymptomatic carriers of HIV or persons without anti-HIV belonging to risk groups. Therefore, HBV could be a factor influencing outcome of HIV infection.

Adult↗
PubMed1991

[Beta-2 microglobulin as a non-specific marker of immunodeficiency in individuals infected with human immunodeficiency virus (HIV)].

Beta-2-microglobulin (beta 2m) is a polypeptide composing HLA antigens on the surface of nucleated cells. Its serum concentration is increased mainly in patients with lymphoproliferative disorders and during viral infections, and reflects probably accelerated activation and turnover of T cells. In this paper we report on abnormalities of beta 2m serum levels in HIV-infected patients. 17 asymptomatic HIV-carriers and 16 persons with clinically overt disease were examined and compared with 20 healthy controls. Patients with confirmed AIDS or ARC were found to have significantly raised beta 2m levels. We found elevated values of beta 2m in asymptomatic HIV-carriers even with normal T4/T8 lymphocytes ratio. There were statistically significant differences in mean beta 2m values between these groups and healthy individuals. beta 2m can be considered as an early, non-specific marker of HIV infection, even in the absence of clinical manifestations of AIDS.

Adolescent↗
PubMed1990

[HIV-1 infection in blood donors and blood recipients].

The results of the tests on HIV-1 infection in blood donors in the years 1985-1989 were presented. Out of 3.222.345 serum samples, in 66 donors HIV-1 antibodies were detected. In 1989 the significant raise of HIV-1 carriers, among whom there were 17 intravenous drug users, was noticed. The transmission of HIV-1 infection to 9 blood recipients was proved. Medical examination of 20 infected blood donors revealed in all of them the enlargement of peripheral lymph nodes. In 8 donors candidosis of oral cavity was diagnosed. The undertaken analysis showed the low efficacy of self deferral and pointed out that medical examination before blood donation should be more carefully done.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Course of acute hepatitis B in alcoholism].

Clinical course of the acute hepatitis B has been analysed in 29 men chronically abusing alcohol. The most frequent source of the infection was surgery and hospitalizations. Clinical course and biochemical findings were similar in this group and in 30 men not drinking alcohol. A sole difference concerned higher GGTP activity in alcoholics. The persistence of HBs antigen was similar in both groups. Chronic alcohol abuse does not seem to have a significant effect on the course and convalescent phase of the acute hepatitis B.

Acute Disease↗
PubMed1989

[Severe alcoholic hepatitis].

A case of severe alcoholic hepatitis was observed in a man aged 30 years. Attention is called to possible diagnostic and therapeutic difficulties. Despite abstinence lasting 9 months the results of biochemical tests failed to return to normal values.

Adult↗