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Biomedical subjects

L B Nelson

Publications and source records attributed to L B Nelson.

At least 19 recordsLinked to original sources

Anterior polar cataract in two sisters with an unbalanced 3;18 chromosomal translocation.

Congenital anterior polar cataracts can be associated with chromosomal abnormalities. We treated two sisters with this condition who had the same unbalanced translocation between the long arm of chromosome 3 and the short arm of chromosome 18. Their mother had a balanced translocation between those chromosomes but had no cataract. Both sisters had dysmorphic features. Their genetic status resulted in partial trisomy of the long arm of chromosome 3 and partial monosomy of the short arm of chromosome 18. To aid in the identification of specific cataract genes, patients with chromosomal abnormalities should have careful ophthalmic examinations, and their lenticular findings should be reported.

Cataract

Diagnosis and treatment of strabismus disorders.

Strabismus is a common ocular abnormality in children and can have significant effects on visual, physical, and psychological development. The causes of ocular misalignment are numerous. Primary care physicians should be skilled in the evaluation of ocular motility in children. They also should understand the basic pathophysiology of common strabismus disorders and be able to identify those children at risk. This knowledge will aid in making a proper referral to an ophthalmologist when a strabismic disorder is suspected or detected.

Child

Disorders of the lacrimal system apparatus.

Epiphora, or excess tearing, is a common problem in infants. The most frequent etiology of this disorder is a nasolacrimal duct obstruction. There are other conditions, however, some of which can be serious, which can cause tearing. Infections of the eyelids and conjunctiva, an undiscovered foreign body, and congenital glaucoma are among the conditions that must be ruled out when any child presents with excessive tearing.

Child

Suture use in pediatric cataract surgery: a survey.

Many different sutures have been advocated for use in closing the corneoscleral incision during cataract surgery. We surveyed 354 North American pediatric ophthalmologists to find out the type of suture they use for pediatric cataract surgery and any associated complications. Of the sutures indicated in the 244 (69%) surveys returned, 10-0 nylon sutures were the most popular choice despite a relatively large number of related complications and the occasional need for general anesthesia to remove them.

Cataract Extraction

Amblyopia. Diagnosis and management.

Amblyopia is a difficult challenge for physicians caring for these children. If detected early with screening programs, the prognosis for successful treatment is greatly increased. If missed, the child may suffer from a lifetime of poor vision in one eye. Children who fail a visual screening test should be promptly referred to an ophthalmologist. Prompt detection and treatment of amblyopia secure a child the best chance for a good visual outcome.

Amblyopia

Unilateral lateral rectus recession for the treatment of exotropia.

Thirty patients with moderate angle exotropia of 15 to 20PD were treated with a unilateral lateral rectus recession of 7.0 or 7.5mm. All 30 patients improved postoperatively to orthophoria, small angle exophoria, or small angle tropia of 10PD or less. Alignment was stable during an average follow-up of 21 months.

Adolescent

Sub-Tenon's infusion of local anesthetic for strabismus surgery.

We used a blunt irrigating cannula to infuse tetracaine 0.5% solution into the posterior sub-Tenon's space in 26 consecutive patients undergoing strabismus surgery under local anesthesia. All patients were sedated with combinations of fentanyl citrate and either propofol or midazolam. The results suggest that this technique is a safe and effective method of performing strabismus surgery under local anesthesia.

Adolescent

Eye injuries in lacrosse: women need their vision less than men?

We describe four cases of ocular trauma incurred while playing women's lacrosse without eye protection. Women's lacrosse is potentially hazardous because, unlike men's lacrosse, helmets and face masks are not required. These ocular injuries could have been prevented with the use of protective eyewear.

Adolescent

Isolated anterior uveitis in a child with acquired immunodeficiency syndrome.

A ten-year-old boy with a four-year history of symptomatic human immunodeficiency virus infection had granulomatous iridocyclitis that subsequently resolved with topical corticosteroid and cycloplegic therapy. This is the first report, to our knowledge, of isolated anterior uveitis in a child with acquired immunodeficiency syndrome.

Acquired Immunodeficiency Syndrome

Peribulbar anesthesia for strabismus surgery.

We prospectively studied 76 patients to analyze the effectiveness of peribulbar anesthesia during strabismus surgery. The patients, ranging in age from 14 to 77 years, were given anesthesia with standard preoperative medication and a peribulbar injection of a mixture of 2% mepivacaine hydrochloride and hyaluronidase. Only one of the 76 patients required an additional injection of anesthetic to achieve adequate anesthesia. No morbidity was associated with the peribulbar anesthesia. Local anesthesia, particularly retrobulbar anesthesia, has been used as an alternative technique in an attempt to reduce the morbidity and mortality associated with general anesthesia in ocular surgery, particularly in those patients with high-risk characteristics. Even with retrobulbar anesthesia, however, there is a risk of morbidity and, in rare cases, mortality. Our results suggest that the use of peribulbar anesthesia is a safe and effective means of anesthesia in strabismus surgery because of minimal associated morbidity.

Adolescent

Removal of radiation-induced cataracts in patients treated for retinoblastoma.

Experience with removal of radiation-induced cataract in patients treated for retinoblastoma is limited. We retrospectively reviewed the records of 38 patients with retinoblastoma (42 eyes) who underwent removal of radiation-induced cataract from 1973 to 1989. Nineteen eyes (45%) without macular tumors or severe radiation complications had final visual acuities in the range of 20/20 to 20/50. One eye (2.4%) developed a rhegmatogenous retinal detachment and four eyes (9.5%) were noted to have amblyopia after cataract removal. Three eyes (7%) developed retinoblastoma recurrence, one with extension of retinoblastoma into the subconjunctival space through the previous sclerotomy. Exenteration was performed and the patient was alive after 8 years. Cataract removal can be visually beneficial in selected patients with radiation-induced cataracts.

Adolescent

Binocularity following surgery for secondary esotropia in childhood.

Binocularity was assessed in children who developed large, constant esotropia following bilateral lateral rectus recessions for intermittent exotropia. Nine such patients were identified who warranted medical rectus recession. Seven were finally aligned within 6 prism dioptres after secondary surgery. Stereopsis measured 50 seconds or better in six of these patients and 200 seconds of arc in the seventh. Two patients had residual deviations: one child with 30 prism dioptres of residual esotropia had 400 arc seconds and the remaining patient, with 12 prism dioptres of exotropia and marked anisometropia, did not show stereopsis. Children with constant acquired esotropia for as long as two years may still have normal stereopsis after surgical alignment. The risk of losing binocularity because of a large overcorrection following exotropia surgery may be smaller than previously assumed.

Child

Diagnosis and management of childhood strabismus.

Strabismus is one of the most common ocular disorders encountered in children. The misalignment may be manifest in any field of gaze, may be constant or intermittent, and may occur at near or distant fixation or both. Early detection of strabismus is essential for restoration of proper alignment of the visual axes and the establishment of binocular vision. The proper assessment and management of a child with strabismus requires knowledge of the various clinical types, methods of detection and principles of treatment.

Child

Outpatient management of traumatic microhyphemas.

Traumatic microhyphema is an entity encountered in emergency rooms and general ophthalmology practices. The management of traumatic microhyphema has not been well defined in the literature. We discuss the effectiveness of our treatment regimen and the incidence of rebleed in patients with microhyphema.

Adult

Hemihang-back recession: description of the technique and review of the literature.

We describe a modification of the hang-back and loop techniques that we call the hemihang-back recession, in which the muscle is reattached to the sclera posterior to the original insertion with a single, absorbable suture. We recommend it for difficult strabismus cases, specifically when recessions of 7 mm or more are required.

Adult