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Biomedical subjects

L B Hansen

Publications and source records attributed to L B Hansen.

86 records · Page 5Linked to original sources
PubMed1982

Dose-response relationships of perphenazine in the treatment of acute psychoses.

A group of 26 acute psychotic patients received continuous oral treatment with perphenazine for a period of 5 weeks. Once-weekly blood samples were drawn for measurements of perphenazine levels and, simultaneously, the therapeutic outcome was registered. Another 26 acute psychotic patients received continuous oral treatment with perphenazine for a period of up to 4 weeks. A single blood sample was drawn and the perphenazine concentration was related to the appearance of extrapyramidal side effects. The following conclusions were made: (1) a high risk of provoking extrapyramidal side effects was associated with plasma levels of perphenazine above 3 nmol/l; (2) plasma levels below 2 nmol/l were associated with a poor therapeutic outcome; (3) a 'therapeutic window' between 2 and 3 nmol/l gives maximal therapeutic effect with a low risk of provoking extrapyramidal side effects.

Acute Disease↗
PubMed1981

Plasma levels of perphenazine (Trilafon) related to development of extrapyramidal side effects.

Thirteen acute psychotic patients received continuous oral treatment with perphenazine for a period of 8 weeks. Blood samples for quantification of perphenazine, perphenazine sulphoxide and prolactin were drawn twice weekly. Simultaneously, the therapeutic outcome and the degree of extrapyramidal side effects were recorded. The following conclusions were made: 1. In accordance with results achieved in one of our earlier investigations, a high risk of provoking extrapyramidal side effects was associated with plasma levels of perphenazine exceeding about 3 nmol/l. 2. An excellent therapeutic outcome was associated with plasma concentrations of perphenazine above 1.5 nmol/l. 3. Plasma concentrations of perphenazine and prolactin were poorly correlated to each other (R = 0.49). 4. A significant correlation (R = 0.85) was shown between the scores for the Brief Psychiatric Rating Scale and the Comprehensive Psychopathological Rating Scale.

Adolescent↗
PubMed1981

Gas chromatographic-mass spectrometric characterization of an alteration product of malathion detected in stored rice.

Four alteration products of malathion have been observed in crop extracts of rice, which may not be readily identifiable in a typical gas chromatographic-mass spectrometric (GC-MS) analysis of the residues. Extracts of rice containing malathion and several related compounds were analyzed on gas-liquid chromatographic (GLC) columns of different polarities. The methyl ethyl succinate ester of malathion co-elutes with malaoxon from a nonpolar GLC column. Retention data and GC-MS analysis indicate the presence of 3 previously reported compounds. Evidence was obtained for a fourth compound, O-methyl O-ethyl S-(1,2-bis-carbethoxy) ethyl phosphorodithioate, apparently resulting from the environmental alteration of malathion.

Gas Chromatography-Mass Spectrometry↗
PubMed1980

Plasma levels of zimelidine and norzimelidine in endogenous depression.

A new serotonin uptake inhibitor zimelidine was studied in 16 endogenously depressed inpatients, who received 150 mg/kg orally during 3--6 weeks in a phase II-type study. Plasma concentrations of zimelidine and its main metabolite norzimelidine were determined twice a week. Ten patients obtained a well-defined steady-state plasma level within 1--2 weeks, while three patients still had increasing concentrations of both substances or only norzimelidine within the investigation period. In two patients, biochemical affection of the liver could be demonstrated during the treatment; one associated with moderate clinical symptoms (dizziness and fever), the other without clinical symptoms. Both patients recovered upon cessation of the zimelidine treatment. In the former patient, very high concentrations of zimelidine at the time of hepatic symptoms were demonstrated, while the latter patient was within the average concentration range. Other adverse reactions were mild and few, particularly with respect to anticholinergic effects. With the applied, probably suboptimal, dosage the therapeutic response was only satisfactory in five cases.

Adult↗
PubMed1979

Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs.

1. A gas chromatographic method was applied to study plasma levels of perphenazine (PPZ) and its major metabolites in man before and during simultaneous antiparkinson treatment. Twenty-six psychotic patients received various forms of PPZ administration as well as antiparkinson drugs. 2. Biperidine (5 mg) was administered intravenously to each of five patients, who 5 days earlier had had a single dose of PPZ-enanthate i.m. No significant alterations in plasma concentrations of PPZ were observed. 3. In fourteen patients receiving oral PPZ treatment the plasma levels of PPZ and its metabolites did not deviate significantly from controls after addition of biperidine or orphenadine given for 3 weeks in fixed oral doses. 4. The ratio between PPZ plasma concentration measured 4 and 7 h after the morning dose was not affected by concomitant antiparkinson therapy. 5. It is concluded that no clinically relevant pharmacokinetic interaction takes place between PPZ and two generally used antiparkinson drugs during steady-state conditions in psychotic patients.

Administration, Oral↗
PubMed1979

Health care requirements of dairy cattle. I. Response to milk yield selection.

To measure direct response to single trait selection for milk yield and correlated response in health problems, two homologous base populations were formed by pairing 66 Holstein females by sire. Base populations and descendants were managed identically except for selection by milk yield. One base and lineage were mated with sires with highest predicted difference milk (selection group); other base and lineage were mated with average sires in 1964 (control group). Milk yield, supplemental labor, and veterinary and semen expense were recorded specific to each cow. Over 9 yr, 130 selection and 163 control cows were observed. Selection cows yielded more milk but with increase in labor and expense for health care. Estimates of labor for the selection group were greater for mammary, locomotion, and digestion categories and for expense in mammary, respiration, first insemination, and later insemination categories. Labor and expense for reproduction did not differ for genetic groups. Differences between groups in annual estimated labor and expense totaled $27.00. Extra income over feed cost more than compensated for greater health care and semen cost; however, the magnitude of the latter indicates a need for them to be considered when economically evaluating breeding programs where major emphasis is on milk yield.

Animals↗
PubMed1977

Plasma concentrations of perphenazine and its sulphoxide metabolite during continuous oral treatment.

Plasma concentrations of perphenazine (PPZ) (Trilafon) and perphenazinesulphoxide (PPZSO) were estimated during a 2-week period in 16 patients receiving peroral PPZ treatment for various psychotic disorders. The results demonstrated that the average concentration of three plasma samples was a reasonably good expression of the steady-state plasma level despite a great fluctuation in the concentration from sample to sample. Increased doses in three of the patients resulted in disproportionate increases in the plasma levels. Neurological side effects were recorded and their relation to plasma concentrations are discussed.

Administration, Oral↗
PubMed1971

Analysis of Clostridium botulinum toxigenic types A, B, and E for fatty and carbohydrate content.

Lyophilized, 48-hr log-phase vegetative cells were extracted with chloroform-methanol (2:1, v/v) and ethanol-ether (3:1, v/v) and then saponified with methanolic KOH. Gas-liquid chromatography of the methyl esters of extractable fatty acids revealed distinctive "pattern profiles" of Clostridium botulinum toxigenic types "A," "B," and "E." C. perfringens type "A" and Escherichia coli strain "B" were also studied in a similar manner and were found to give pattern profiles which were distinct even from those obtained for the C. botulinum microorganisms. Amino sugar content of the five microorganisms was determined by using a Beckman amino acid analyzer. The molar ratio of glucosamine to that of galactosamine was found to be of further assistance in distinguishing the individual microorganisms.

Amino Acids↗