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Biomedical subjects

L Andersson

Publications and source records attributed to L Andersson.

At least 415 records · Page 23Linked to original sources
PubMed1984

Effect of domiciliary treatment with nebulized beta 2-stimulants--a retrospective follow-up of 102 patients.

A retrospective follow-up of 102 patients with beta 2-stimulant nebulizers prescribed for domiciliary use was made to find out the extent to which the device was actually used, the effect on the need for hospital care and steroid treatment and the cause and place of death in relation to all asthma deaths. Of 53 patients seen in their homes, more than half used the nebulizer continuously. Two patients returned their nebulizers due to improvement of symptoms. A slight but not statistically significant reduction of hospital care was seen during a two-year period after the prescription compared to before. Patients with hypersecretion as the main problem seemed to benefit more by the treatment than obstructive patients. Asthma deaths outside hospital were not more frequent in patients with a nebulizer (84 per cent) than without (75 per cent). In two patients out of six dying from status asthmaticus outside the hospital, it could not be ruled out that the patient had relied too long on the bronchodilating effect of the nebulized beta 2-stimulant instead of coming to the hospital for additional treatment for the oedema and plugging. More information to patients about this risk is necessary.

Adult↗
PubMed1984

Periodontal conditions following surgical exposure of unerupted maxillary canines--a long term follow-up study of two surgical techniques.

Two surgical techniques for exposure of impacted labially positioned maxillary canines were compared as to periodontal conditions at the end of the orthodontic treatment period. In the radical exposure group the alveolar mucosa and bone covering the crown were removed. In the other group a pedicle flap including keratinized gingiva was used for exposure. After the removal of bone the flap was apically positioned and sutured. The non-treated contralateral canines served as controls. The result showed that radical exposure in the region of alveolar mucosa resulted in significantly reduced width of buccal keratinized gingiva, reduced sulcus depth, increased gingival recession and increased gingivitis. The difference between the apically positioned flap group and the non-treated control groups was not significant.

Adolescent↗
PubMed1983

Toxic effects of ethylenediamine dihydroiodide treatment in Swedish calves.

To study the preventive effect of supplementary iodine on interdigital phlegmon, 50 Swedish red and white calves weighing approximately 100 kg each were given 1 mg ethylenediamine dihydroiodide (EDDI) per kg bodyweight daily. Fifty calves in the same herd were untreated controls. As a result of severe side effects the experiment was interrupted after five weeks. No case of interdigital phlegmon was observed, but 31 calves in the EDDI group and one in the control group were treated for respiratory disease. Serum protein bound iodine increased on average from 68.0 to 213.0 micrograms/litre in the EDDI group compared to an increase from 59.9 to 70.7 micrograms/litre in the control group.

Animals↗
PubMed1983

Diagnosis of deep venous thrombosis by 99mTc-human serum albumin microcolloid.

99mTc-human serum albumin microcolloid (HSAC) was evaluated for diagnosis of deep venous thrombosis (DVT) in the legs of 38 consecutive patients. Five and thirty minutes after IV injection, the 99mTc-HSAC activity in both legs was measured by external counting using a collimated NaI (T1)-detector. The relative predominance of 99mTc-HSAC activity in the diseased leg was calculated. Phlebography was performed as a control after the 99mTc-HSAC test. In our hands the non-invasive 99mTc-HSAC test appeared to be rapid, easy to perform and convenient to the patient. The test showed a high sensitivity (11/13) and a low specificity (10/20) compared with phlebography. No adverse reactions were found. The results seem promising and further studies are in progress to establish the value of the 99mTc-HSAC test in screening for DVT.

Adult↗
PubMed1983

Small renal caliceal calculi as a cause of pain.

We report 7 cases of long-standing lumbar or flank pain associated with small renal calculi located peripherally in a calix and no obvious obstruction. After stone removal by percutaneous puncture the patients were relieved of the pain.

Adult↗
PubMed1983

Genetic linkage between the loci for phosphohexose isomerase (PHI) and a serum protein (Xk) in horses.

Genetic linkage between the equine loci for phosphohexose isomerase (PHI) and serum Xk protein was demonstrated by means of segregation data from three sire families. The recombination frequency was estimated from pooled data to be 0.23 +/- 0.02; a significant heterogeneity between sires for estimates of the recombination frequency was observed. No indication of linkage was detected between Xk and 14 other blood marker loci. Linkage between the Xk locus and the locus for soluble malic enzyme (ME1) has recently been reported in horses. An equine linkage group designated LG IV comprising the three loci ME1, PHI, and Xk has thus been established. The possibility that the linkage between PHI and Xk is homologous to the linkage between the loci for PHI and a serum postalbumin (PO-2) in pigs was discussed.

Animals↗
PubMed1983

A clinical evaluation of serum placental alkaline phosphatase in seminoma patients.

Serum levels of placental alkaline phosphatase (PLAP) were measured in 100 patients with seminoma. A specific double antibody radioimmunoassay was used. PLAP was elevated for 9 out of 21 patients with primary tumours, to a mean of 53 micrograms/l. Of the 12 cases with recurrent or metastatic growth, nine had raised PLAP. The sensitivity of PLAP determinations for primary and advanced disease was 55%. After successful treatment of seminoma, the PLAP level decreased. In a group of 68 patients with no evidence of disease, nine had slightly elevated serum PLAP. In many, but not all patients, serum PLAP parallelled the changes in tumour burden. In such patients and for follow-up of treatment, PLAP might be used as a new marker for seminomatous disease.

Adult↗
PubMed1983

Contact lens wear in an environment contaminated with metal particles.

Ten subjects wearing soft contact lenses on a daily basis and working in an environment moderately contaminated with metal particles were followed for an average of 24 months. There were no signs of ocular damage and no history of eye irritation. Some contact lenses showed occasional brownish excavations, representing earlier lesions from burning particles, the lens thus having protected the cornea. Very few metal particles were seen on the lens when still on the eye and extremely few when studying removed lenses in light microscopy. Apparently particles were eliminated fairly easily be the tear fluid, by blinking and by daily cleaning. Atom absorption analysis of worn lenses showed only nanogram amounts of metal, not dissimilar to those in lenses worn by office employees. The lenses did not need to be replaced more often than for a group of office employees. Soft contact lenses apparently may be worn without damaging the eye in an environment moderately contaminated with metal particles, provided the lenses are properly cleaned. Contact lenses allow closer fitting of protective goggles compared to glasses; which is advantageous.

Adolescent↗
PubMed1983

Storage of experimentally avulsed teeth in milk prior to replantation.

Extracted monkey teeth were endodontically treated, stored in milk or saliva for two or six h, and then replanted. Periodontal conditions were evaluated after eight wk. Teeth that had been stored for two or six h in milk or for two h in saliva showed periodontal healing almost as good as that of immediately replanted teeth. Teeth that had been kept in saliva for six h or bench-dried for one h showed extensive replacement resorption. Milk may thus be recommended as a storage medium for ex-articulated teeth prior to replantation in cases when immediate replantation is not possible.

Animals↗
PubMed1983

Periodontal healing of replanted monkey teeth prevented from drying.

Root resorption of replanted teeth is dependent on the duration of the extra-alveolar period and on the storage environment. In the present investigation the significance of preserving the humidity of the periodontal ligament (PDL) during the extra-alveolar period was tested on isolated PDL cells and on replanted monkey teeth. The isolated PDL cells were tested with respect to cell viability (trypan blue exclusion test) and to cell recovery (number of cells after additional cultivation). About 70% of the cells were viable and 44% recovered after 1 h in a humid atmosphere. Practically no cells were viable or recovered after 1 h of drying. Replanted teeth that had been wrapped in plastic foil for 1 h before replantation showed no more resorption than immediately replanted teeth. This is in contrast to teeth dried in air for 1 h before replantation. They showed extensive root resorption on almost all root surfaces. Thus, prevention of evaporation of tissue fluid from the PDL must be considered a primary goal if the tooth cannot be replanted immediately.

Animals↗
PubMed1983

Cisobitan in treatment of prostatic cancer. A prospective controlled multicentre study.

Cisobitan, an organosilicon compound with estrogenic and antigonadotropic properties has been evaluated clinically in comparison with an estrogen preparation. In a multicenter study a total of 140 patients with well and moderately well differentiated prostatic cancer were randomly allocated to treatment with Cisobitan or Estradurin/Etivex, 70 to each group. Of 34 patients with poorly differentiated prostatic cancer 18 were given Cisobitan--and 16 were given Estracyt-treatment. Among the patients with well and moderately well differentiated prostatic cancer there were, disregarding mortality, no major differences in subjective, objective or laboratory response to the two kinds of treatment. The pattern of side effects was similar, but oedema requiring diuretics occurred more often in the estrogen treated group. There was a significant difference in mortality at 12 months between the groups, two in the Cisobitan group and ten in the estrogen treated group. Cancer was the cause of death in two patients in the estrogen treated group. All other patients succumbed in cardiovascular diseases. At 24 months the difference in mortality rate was less pronounced: Another ten patients had died in the Cisobitan treated group and seven among the estrogen treated patients. Cancer was responsible for the deaths in seven of the Cisobitan patients compared to four of the estrogen treated patients. Within three years one more patient in both groups had died. Of the 34 patients with poorly differentiated cancer, twelve were alive at the 24 months' follow up, six in the Cisobitan group and six in the Estracyt group.

Clinical Trials as Topic↗
PubMed1983

Pregnancy outcome among women in a Swedish rubber plant.

Suspicions of reproductive disturbances among women in a tirebuilding department was the reason for this study, encompassing 42 women, 30 of whom provided a total of 84 pregnancies out of which 21 were exposed to the tirebuilding process. Nine of the 21 exposed pregnancies had an unfavorable outcome (threatening abortion, spontaneous abortion or malformation) versus only seven of the remaining 63 nonexposed pregnancies, a difference which remained significant also when various risk indicators like age, smoking, pregnancy order, and calendar year were taken into account. In contrast to earlier observations, there was no difference in thioether excretion in the urine (as potentially indicative of the skin absorption of rubber chemicals) between women working in the tirebuilding department and a reference group. It remains unclear however whether the observed cluster was causally related to occupational exposures or not, but, together with other observations, this report may contribute to the elucidation of possible reproductive disturbances in the rubber industry.

Abnormalities, Drug-Induced↗
PubMed1982

alpha-aminoaldehydes: transition state analogue inhibitors of leucine aminopeptidase.

L-Leucinal, prepared by enzymatic oxidation of L-leucinol with alcohol dehydrogenase, is found to be a very strong competitive inhibitor of porcine kidney aminopeptidases. For the enzyme from kidney microsomes acting on L-leucine p-nitroanilide (Km = 5.2 x 10(-4) M), for Ki for L-leucinal was 7.6 x 10(-7) M at pH 7.2 and 25 degrees C. For the enzyme from kidney cytosol acting on L-leucine p-nitroanilide (Km = 7.7 x 10(-4) M), Ki for L-leucinal was 6 x 10(-8) M; Ki for glycinal (analogous to glycine derivatives that are poor substrates) was 6.8 x 10(-4) M. In dilute aqueous solution, leucinal exists in unfavorable equilibrium with its covalent hydrate, whose concentration exceeds that of the free aldehyde by a factor of 40. The affinity of the enzyme for the free aldehyde is correspondingly greater than its Ki values would suggest, exceeding the apparent affinity of the substrate by a factor of about 10(6). A comparison of binding affinities suggests that L-leucinal forms an inhibitory complex analogous in structure to unstable intermediates and substrate transformation by leucine aminopeptidase, and strengthens the likelihood that this enzyme may act by a double-displacement mechanism.

Anilides↗