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Biomedical subjects

L A Panchenko

Publications and source records attributed to L A Panchenko.

30 records · Page 2Linked to original sources
PubMedDate not supplied

[Changes in cell mitosis under the influence of antigenically different strains of respiratory syncytial virus].

A peculiar effect on mitosis of RH cells of the reference Long strain and strain No. 14 of respiratory syncytial virus isolated during a rise of the incidence of acute respiratory diseases in Kharkov was observed. The Long strain affected mostly the qualitative and strain No. 14 the quantitative aspects of cell mitosis. The character of pathological mitoses under the influence of the Long strain indicated more considerable impairment of the mitotic apparatus of the cells than that caused by the strains No. 14. It is suggested that the peculiarities of the effect of the two respiratory syncytial virus strains on cell mitosis are associated with the structural and antigenic differences in the strains circulating in various geographic zones.

Animals↗
PubMedDate not supplied

[Optimizing conditions of cell culture use for virus indications by means of fluorescent probes].

Cell cultures in a suspension on medium 199 with 1 x 10(6) cells per ml are recommended for virus indication by means of fluorescent probe method. When stored at 4 degrees C, the cells are fit for work for 5 days. The proposed conditions for the use of cell cultures are necessary for effective introduction of the fluorescent probe method in practical virological laboratories.

Animals↗
PubMedDate not supplied

[The structure and immunobiological properties of coronavirus proteins].

The survey includes data concerning structural proteins of coronaviruses obtained for the last ten years. It elucidates such problems as the proteins organization in the virion, heterogeneity of their composition, structure and biological properties, antigenic and immunobiological properties, prospects of creation of specific immunogenic anticoronavirus, prophylactic and diagnostic preparations.

Antigens, Viral↗
PubMedDate not supplied

[The variability of the scabies mite Sarcoptes scabiei de Geer (Acariformes, Sarcoptidae) in relation to the epidemiology of scabies. 4. The variability of the mite population on a patient and its focal variability].

The authors analyze the individual variability of the agent of scabies in populations on individual patients and in foci of the disease. They define an elementary micropopulation and a focal population notions. A total of 763 females, collected from the hands of 100 patients with scabies were examined. The findings evidence that the degree of the chetoid covering joining in the mite females, assessed in grades, may be regarded as an indicator of the population status in the pathologic process. Grades II and III females predominate in the mite population on the patients during the initial period of the disease (up to a month), whereas in the course of a full-bloom process (over a month) Grades I and 0 females prevail. The attendant exo- and endogenous factors shift the grade composition of the females towards the higher grades whatever the length of the disease. A great variety of the females in focal populations evidences reinfection and continuity of the process.

Animals↗
PubMedDate not supplied

[Integral equations of the theory of liquid in the study of hydration of macromolecules].

An efficient numerical algorithm for solving integral equations of the theory of liquid in the RISM approximation for infinitely diluted solution of macromolecules with a large number of atoms is proposed. The algorithm is based on applying the non-stationary interactive methods for solving systems of linear algebraic equations. Using this technique we have calculated the solvent-solute atom-atom correlation functions for short fragment of DNA duplex of varying length in aqueous solution.

Biopolymers↗
PubMedDate not supplied

[Hydration of a fragment of the B-form of DNA duplex: d(GGGGG). A method of integral equations of the theory of liquid].

Based on the numerical algorithm proposed by us in [1] for solving integral equations of the theory of liquids in the RISM approximation we calculate all of the solvent-solute atom-atom correlation functions for a fragment of the DNA duplex d(GGGGG) in infinitely diluted aqueous solution. The obtained results are compared with available experimental data and results from computer simulations.

DNA↗
PubMedDate not supplied

[The use of the fluorescent probe method for the diagnosis of acute coronavirus intestinal infections in people].

The scientific investigations conducted first allow using a method of fluorescent probes for the diagnosis of human coronaviral intestinal infection. The method is characterised by sensitivity, specificity, reproductivity and proximity. It is comparable, according to these parameters, with the methods of the third generation and may be recommended for putting into practical work of virological laboratories.

Acute Disease↗