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Biomedical subjects

L A Page

Publications and source records attributed to L A Page.

At least 37 records · Page 2Linked to original sources
PubMed1978

Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent.

Paired sera from victims of Legionnaires' disease showed, in many cases, significant rises in immunoglobulin G antibodies to both the causative agent (LA) of Legionnaires' disease and Chlamydia psittaci, but concurrent rises in immunoglobulin M antibodies only against LA. Guinea pigs experimentally infected with LA likewise responded with antibodies to both C. psittaci and LA. Guinea pigs infected with LA also reflected significant differences in antigenic makeup and in pathogenicity among four strains of LA examined. In antibiotic studies, rifampin was 200 times more effective than erythromycin and 17,000 times more effective than tetracycline in plaque reduction tests of LA in monolayer cultures of primary chick embryo cells. An isolate of LA recovered from a healthy person was compared with three isolates from persons with fatal infections.

Animals↗
PubMed1976

Observations on the involvement of wildlife in an epornitic of chlamydiosis in domestic turkeys.

In an investigation of potential wildlife reservoirs of Chlamydia psittaci at the site of an acute, highly fatal epornitic of chlamydiosis in domestic turkeys in Texas, various species of wild birds and rodents were captured and tested for chlamydial serum antibodies and chlamydiae in their tissues. Thirteen (65%) of 20 blackbirds (Agelaius sp), 4 (44%) of 9 killdeer (Oxyechus vociferus), 3 (27%) of 11 sparrows (Passer sp) and 1 of 4 mourning doves (Zenaidura macroura) were seropositive, but chlamydiae were not isolated from their tissues. Two of 3 rats (2 cotton rats, Sigmodon hispidus, and 1 roof cat, Rattus rattus) were seropositive, but 7 gophers (Citellus sp), 1 ground squirrel (Tamias sp), an opossum (Didelphis virginiana), and a domestic cat (Felis domesticus) were seronegative; however, chlamydiae were recovered from the livers and spleens of the opossum and domestic cat, both of which had been observed scavenging carcasses of turkeys dead of chlamydiosis. Cultures of these isolants were inoculated experimentally into turkeys and produced lesions of chlamydiosis that were indistinguishable from those caused by the strain originally recovered from diseases turkeys on the premises. Nine of 50 domestic goats quartered near the diseased turkeys were tested, and all were seropositive.

Animals↗
PubMed1975

An epornitic of fatal chlamydiosis (ornithosis) in South Carolina turkeys.

An unusual epornitic of fatal chlamydiosis occurred in a flock of 10,283 domestic turkeys in South Carolina. Total mortality over a 2-week period was 483 birds (4.7% of the flock). The principal gross lesion was severe pericarditis, but there was little or no airsacculitis, an observation at variance with many previous reports of chlamydiosis. Furthermore, an unusually heavy infestation of the turkeys with sanguivorous black flies (Simulium slossonae and S congareenarum) was observed at the time of the epornitic, an occurrence that may have permitted rapid transmission of chlamydiae between turkeys in the affected flock. The strains of Chlamydia psittaci isolated from naturally infected turkeys caused pericarditis and heptopathy as well as occasional airsacculitis, with a 41% mortality in intravenously (IV) inoculated turkeys. Turkeys inoculated intramuscularly (IM) or intraperitoneally (IP) did not die; however, airsacculitis was observed in more than 85% of turkeys inoculated intraperitoneally or exposed to infection by pen contact with inoculated turkeys. The strain was highly infectious but not lethal by the latter method of transmission. The strain was similar to other virulent chlamydiae isolated from turkeys, in that small numbers of the organism caused fatal infection in guinea pigs when inoculated IP.

Air Sacs↗
PubMed1975

Naturally occurring and experimentally induced mycoplasmal arthritis of cattle.

Mycoplasma agalactiae subsp. bovis strain Iowa 1136 was isolated from synovial fluids of a clinical case of arthritis in cattle on pasture in Iowa. When given to calves and cows by intra-articular or intravenous injection, it caused severe and persistent joint infections with fever, lameness, and swelling of the affected joints, plus synovitis, tendonitis, and fibrinous-purulent synovial fluids of high protein content. Intramammary administration of the organism caused severe mastitis. Calves nursing the cows developed severe mycoplasmal arthritis.

Animals↗
PubMed1972

Detection of chlamydial antibodies in animal sera by double diffusion in gel.

Postinoculation sera collected from pigeons, turkeys, guinea pigs, sheep, a calf, a rabbit, and a horse experimentally infected with various strains of Chlamydia psittaci yielded a high incidence of positive reactions when tested by double diffusion in gel. Antigen was a deoxycholate extract of SA-2 strain of C. trachomatis. Good correlation was obtained with results of complement fixation tests, whereas double diffusion in gel was less sensitive. Immunoelectrophoresis of the antigen revealed presence of two antigens in the extract.

Animals↗