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Biomedical subjects

K Wonigeit

Publications and source records attributed to K Wonigeit.

At least 217 records · Page 12Linked to original sources
PubMed1978

[Immunologic monitoring of transplantation patients: study of the reactivity of cytotoxic precursor cells].

Proliferative and cytotoxic T-cell reactivity subsequent to in vitro stimulation by a lymphocyte pool were studied in ten patients with well-accepted cadaver renal allografts and eight healthy controls. Whereas the proliferative reactivity was about equal in both groups, the cytotoxic responsiveness was markedly reduced in the allograft recipients. We conclude from these results that immunosuppressive drugs as well as specific adaptation processes act preferentially on the cytotoxic precursor cell population.

Cell Division↗
PubMed1977

[Causes and risks in a interruption of systemic immunosuppressive therapy following kidney transplantation].

The immunosuppressive therapy of 22 transplant recipients was temporarily suspended 25 times resulting in rejection reactions in 7 cases with the eventual loss of five transplants. One patient succumbed to fungal infection following the loss of kidney function. No connection between the risk of rejection and the previous number of rejection treatments or the histocompatibility could be established. Acute rejection reactions mostly occurred immediately after the interruption of therapy. There was no increased risk associated with a longer break in treatment. Interruption of therapy during the first period of immunosuppressive treatment, that is approximately 3 months after transplantation, was associated with the lowest risk of rejection. As a result of our experience in 25 cases it appears that the temporary suspension of immunosuppressive therapy is associated with little risk and avoids a drug intoxication as well as reduces the mortality due to infection.

Azathioprine↗
PubMed1977

Suppression of specific MLC responsiveness during skin allograft rejection in rats.

During the effector phase of allograft rejection a specific MLC unresponsiveness of PBL has been observed in skin-grafted rats. This unresponsiveness is caused by a suppressive effect that is dependent on a cooperative interaction between macrophages and alloantigen-activated T cells. The interaction is mediated by a soluble factor released from the alloantigen-activated T cells on exposure to the specific antigen. The suppression itself is nonspecific.

Animals↗
PubMedDate not supplied

Experiences with liver transplantation in Hannover.

Ninety orthotopic liver transplantations in 86 patients performed between 1972 and 1983 in the Medical University of Hannover are reviewed. Results in tumor patients (n = 46) are characterized by a high rate of early tumor recurrence. A few patients survived for prolonged periods, and some were cured. More experience is required to define more precisely suitable kinds and stages of malignancies so that liver grafting in tumor patients can be confined to situations with a favorable prognosis. The main problem of liver transplantation in cirrhotics (n = 40) is the appropriate time of indication. It is suggested that liver grafting be performed more often in an "elective" situation. This phase during the course of cirrhosis must be optimally defined by analysis of the underlying disease and by individual situation. Results of liver grafting in elective situations are better than those in emergency situations and may offer a tangible chance for cure. Liver grafting in pediatric patients gives the best results, although procurement of small donor organs is a major problem. More experience, better immunosuppression with cyclosporin A, and the search for the appropriate time of indication contribute to improvement in the results of liver grafting.

Adolescent↗