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Biomedical subjects

K Winnefeld

Publications and source records attributed to K Winnefeld.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Desferal treatment of aluminum poisoning; effect on serum concentrations of aluminum (Al), iron (Fe) and copper (Cu)].

In 2 patients with a progressive dialysis encephalopathy and increased serum aluminium concentrations a Desferal-treatment with 500 mg per week was performed and in these cases the kinetics of Al, Fe, Cu was investigated. After the application of Desferal an increase of the serum levels, the ultrafiltrable proportion, the dialysance and the eliminated quantity of aluminium developed. In the course of the treatment in the two patients the aluminium level could be reduced to approximately normal values. Nevertheless one patient died of a severe course of a progressive dialysis encephalopathy. An increase of the copper concentration independent of Desferal-treatment after the dialysator passage remained without influence on the course of concentration of the serum copper in the examination period. A remarkable effect of the Desferal-therapy on the iron metabolism could not be established. Since in the dosage used there did not appear any side effects the Desferal-application is to characterized as a distinct and effective technique for the decrease of the serum-aluminium-concentration in patients undergoing dialysis.

Adult↗
PubMed1985

[Effect of Visotrast (R) and bilirubin on lipase and alpha-amylase activities of pancreatic secretions].

The contamination of pancreatic juice obtained by endoscopic retrograde catheterism of the papilla by cannulation of the pancreatic duct with contrast medium is possible. When the amount of "VisotrastR 370" is more then 0.05 ml per ml one observes a decrease of the lipase while alpha-amylase is unchanged.--Bilirubin has also an influence on the activity of lipase - but not on the alpha-amylase.

Bilirubin↗
PubMed1984

[Behavior of serum iron levels and total iron-binding capacity following gastrectomy].

Iron and the total iron binding capacity before and after an application of iron per os using the method of atomic absorption were determined in serum of 18 patients with a gastrectomy. The results were compared with a healthy group without a gastrectomy. We could not find significant disturbances of the enteral resorption of iron. But some patients show symptomes of a latent iron deficiency. After an operation the routine substitution of iron per os in patients without the stomach is indicated.

Adult↗
PubMed1981

Binding of magnesium and chloride ions to human hemoglobin A. Mg2+ concentrations in solutions simulating red cell conditions.

Ultrafiltration and direct determination of [Mg2+] by ion exchange were used to study the binding of Mg2+ and Cl- to isoionic human hemoglobin. A value of 58.8 +/- 1.7 l/mol was determined for the volume of hydrated hemoglobin from ultrafiltration of hemoglobin solutions containing 0.15-0.8 M glucose. In solutions with 5.7 mmol hemoglobin, 150 mmol KCl and 0.5-3.5 mmol MgCl2/l total water, 0.6 mol and 2 mol Cl- were bound/mol oxygenated and deoxygenated hemoglobin respectively. A value of about 11 l/mol was determined for the association constant of Mg2+ to hemoglobin monomer. Free Mg2+ concentrations were measured in hemoglobin solutions containing KCl, MgCl2, ATP and D-glycerate-2,3-bisphosphate at concentrations close to those of red cells. The experiments yielded 0.65 mmol/l free Mg2+ after oxygenation and 0.82 mmol/l after deoxygenation. The data indicate that only small changes of free Mg2+ levels in red cells are caused by physiological changes of pO2.

Chlorides↗
PubMed1981

[Isoelectric behavior of oxyhemoglobin].

This paper presents changes of the isoelectric behaviour of hemoglobin depending on the ionic strength and the buffer system. With increasing ionic strength the isoelectric point of oxy-hemoglobin changes to lower pH-values. The isoelectric function of oxy-hemoglobin is different in various buffer systems.

Buffers↗
PubMed1978

[Control of mitochondrial Mg++-efflux].

Inorganic phosphate stimulates the release of Mg++ from liver mitochondria, depending on concentration; a concentration as low as 0.1 mM phosphate is already effective. The process is dependent on the electron transfer of the respiratory chain, and its rate is highest under conditions of endogenous respiration and with ascorbate and TMPD as substrates, respectively. The phosphate stimulated release of Mg++ is followed, with a pronounced delay, by a Ca++ efflux and a swelling of mitochondria. Addition of EGTA strongly reduced the rate of Mg++ liberation in the presence and absence of inorganic phosphate. Exogenous Ca++ is able to abolish the EGTA effect. ADP and ATP inhibit the phosphate stimulated release of Mg++. Phosphoenol pyruvate and free fatty acids enhance the rate of Mg++ and Ca++ efflux from the mitochondria. The results permit the conclusion that inorganic phosphate, Ca++ and various metabolites of the cell metabolism influence the Mg++ distribution between the extra- and intramitochondrial space, thus controlling the permeability of the mitochondrial inner membrane for monovalent cations.

Animals↗
PubMed1978

[Steroid-examinations in serum of old men as a functional testing of the suprarenal glands (author's transl)].

A surgical intervention is dangerous for the old patient awing to the reduced reactiveness and polymorbity. The knowledge of the function of the suprarenal glands in stress (operation) is important. The latent insufficiency of the suprarenal glands is determined with the ACTH-stimulations test. 136 patients from 60 to 100 years were proved. In the case of a latent insufficiency of the suprarenal glands the substitution of glucocorticoids and ACTH is necessary.

11-Hydroxycorticosteroids↗
PubMed1977

[Cis-polyenecarboxylic acids and other fat-metabolism parameters in carcinoma of the digestive tract].

In 24 patients with a neoplasm of the gastro-intestinal tract cis-poly-unsaturated fatty acids were determined in the serum together with cholesterol, free and total glycerin as well as with neutral fats. In the cis-polyene acids a statistically ascertained diminution occurs, all the other parameters remain practically unchanged. To what extent very low values of poly-unsaturated fatty acids are to be connected must still be tested. It cannot be judged about a correlation of cancer and values of neutral fats, since the breadth of the normal area of this parameter of fatty metabolism is very large and the number of test persons is relatively small. The content of cholesterol of patients with cancer is prettily constant and deviated only little from the normal.

Adult↗
PubMed1977

[Ion concentration in the cerebrospinal fluid in multiple sclerosis].

The concentrations of electrolytes Na, K, Ca, Mg, and Cl and trace elements Cu and Zn were determined in the lumbar cerebrospinal fluids of forty patients with multiple sclerosis. Metal ion concentrations were measured using atomic absorption spectroscopy and flame photometry, respectively. Compared with corresponding values obtained from a control group, statistically significant increases in concentration of Na, Cl, Ca, and Zn have been found. Also reported are the results of determinations of ion concentrations in cerebrospinal fluids obtained from patients suffering from diseases other than multiple sclerosis. Possible causes of deviations from the norm are discussed.

Calcium↗