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Biomedical subjects

K Widhalm

Publications and source records attributed to K Widhalm.

At least 145 records · Page 8Linked to original sources
PubMed1980

Serum lipoproteins in patients with clinical signs of atherosclerosis: peripheral vascular and coronary heart disease.

Lipid and lipoproteins were examined in 7 males patients with coronary heart disease, 10 males with coronary heart and peripheral vascular disease, 25 males with peripheral vascular disease and 10 females with peripheral vascular disease aged between 50-60 years. In general our results demonstrate that in all patients with different locations of atherosclerosis elevated concentrations of total cholesterol, LDL-cholesterol and triglycerides can be found. However low HDL-cholesterol levels measured in all groups should be pointed out. From our data it is concluded that there does not exist a typical lipid or lipoprotein pattern in patients with different locations of atherosclerosis. Only minor differences exist concerning the concentrations of the major lipids and lipoproteins.

Arteriosclerosis↗
PubMed1979

HDL- and LDL-cholesterol in normal weight healthy children 13 years of age.

From 108 healthy 13 years old school children who took part on a longitudinal study in regard to serum lipids and lipoproteins 64 with normal body weight were examined. Lipoproteins were estimated by means of preparative ultracentrifuge and polyanionprecipitation (Heparin and Manganese-chloride) according to the Lipid Research Clinics Methods, NIH, Bethesda. Mean values and S.D. were calculated as: Total cholesterol: 155 +/- 29, 150 +/- 35 mg/dl; LDL-cholesterol 98 +/- 21 and 96 +/- 34 mg/dl; HDL-cholesterol 44 +/- 13 and 44 +/- 13 mg/dl for males and females respectively. The few data from the literature showing wide variations in LDL- and HDL-cholesterol concentrations are compared with our results; methodological considerations indicate that for further epidemiological studies concerning the possible risk factors for premature atherosclerosis standaradized laboratory tests should be provided.

Adolescent↗
PubMed1978

[The toxicity of lincomycin. Two i.v. applications of 6 g. each to a 10 year old girl without toxic symptoms].

A 10-year old girl (34.5 kg) being treated at our clinic for osteomyelitis erroneously received an overdose of lincomycin. On a single day she was given 2 infusions containing 6 g of lincomycin each, which corresponds to a dose of 343 mg/kg of body weight. There was an interval of 10 h between infusions. Apart from fatigue and unpleasant taste sensation, she demonstrated no signs of intoxication. None of the laboratory parameters (GOT, GPT, gamma-GT, LDH, G-LDH, LAP, alkaline phosphatase and CK; furthermore, the concentrations of glucose, BUN, creatinine, uric acid and bilirubin) offered any evidence of toxic organ damage. Osteomyelitis in children demands extremely high doses of antibiotics. In view of this fact, the therapeutic range of a substance is of utmost clinical interest.

Child↗
PubMed1976

[Long-term use of medium chain triglycerides in cystic fibrosis (author's transl)].

Conventional treatment of 15 children (aged 4 to 17 years) with cystic fibrosis and persistent failure to thrive was supplemented on an out-patient basis by a daily oral intake of 35 g of medium chain triglycerides (MCT) fat. Follow-up investigations were pursued for a longer period than described in the literature, namely up to 6 months after initiation of the MCT diet. While frequency of the bowel movements was reduced and abdominal discomfort disappeared no weight gain was observed. Clinically, steatorrhoea was clearly diminished. Pre-treatment serum cholesterol levels were lower (121 mg/dl, n=25) than in healthy subjects (182.2 mg/dl, n=56). No significant changes in either serum cholesterol or serum triglycerides were detected over the 6-month period. There were no clinical signs of an essential fatty acid deficiency in 4 patients followed up for 2 years so far. MCT fat should be included in the standard dietary regimen used in the management of any child with cystic fibrosis and failure to thrive. Its use is fully justified by the clinical improvement and alleviation of the steatorrhoea.

Adolescent↗
PubMed1976

[Cortisone in non-hemorrhagic stroke. An anterospective comparative study (author's transl)].

In an open, randomized anterospective, comparative study on encephalomalacias it was shown that with regard to the parameter of rehabilitation progress in the degree of paralysis, the patients treated with cortisone had a significantly better performance at the 5% level. The main point of attack of cortisone appears to be in the early phase of the insult (first 5 days). It seems unlikely that edema control is the only active principle. More probably this is an additional effect on cell metabolism. From these results it seems logical to continue to follow up the acute treatment of cerebral insult with cortisone and search for an optimal dosage and better confirmation.

Aged↗
PubMed1976

[Treatment of extreme obesity in a case of Prader-Willi-Labhart-syndrome (author's transl)].

A boy 14 years of age, weighing 93,45 kg and 143 cm in height was refered to our clinic with hyperphagia and pain in the joints. The patient showed the Prader-Labhart-Willi-syndrome. Through maximal diet therapy, 2 admittances in our ward and through intensive psychological outpatient care, we have seen a weight loss of 26 kg in 18 months and clear improvement in the patient's health. We would like to draw attention to the fact that a weight reduction diet is a cooperative family effort. To satiate uncontrollable hunger an intermittent dose of Fenfluramine (0,5 mg/kg) is recommended.

Adolescent↗
PubMed1976

[Combination of the syndrome of Sturge-Weber and the syndrome of Klippel-Trénaunay (author's transl)].

Up until now 39 cases of combined Klippel-Trénaunay syndrome and Sturge-Weber syndrome have been described. Here follows the report of a girl, now 4 years of age, displaying a full combination of these syndromes. Only a small part of the body surface is not covered with naevi teleangiectatici laterales. The patient has clear hypertrophy of the left cheek and of the left lower extremity, less noticeable on the left upper extremity. For therapeutic reasons the left side of the head and the left lower extremity were thoroughly angiographically examined--this revealed typical abnormalities. The vessel-alteration of the lower extremity are not extremely far developed and arteriovenous fistulas on a large scale are also absent. This allows us to dismiss the F.P. Weber syndrome on the one hand, while it explains the absence of complications of the Klippel-Trénaunay syndrome, as described in literature, on the other. The significance of the alterations of lymph nodes in this disease, which we are the first to describe, is at present not fully clear. The cerebral attacks have until now showed only a temporary response to medication.

Angiography↗
PubMed1976

Creatine kinase isoenzymes in cerebrospinal fluid in a case of brain damage.

We present a case of a 11/2-year-old boy with toxic enteritis, consecutive consumption coagulopathy, and sever brain damage. During the acute phase we found high activity of the BB isoenzyme of creatine kinase in cerebrospinal fluid, but not in the serum. Isoenzyme MM could also be found in the spinal fluid (37.9% of the total activity). We conclude that analysis for creatine kinase isoenzymes in spinal fluid is of clinical importance.

Brain Injuries↗