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Biomedical subjects

K Weismann

Publications and source records attributed to K Weismann.

At least 127 records · Page 7Linked to original sources
PubMed1982

Local panatrophy with linear distribution: a clinical, ultrastructural and biochemical study.

A young female with local panatrophy of the right-side extremities affecting all mesodermal layers--dermis, subcutaneous tissue, muscles, and bone--is described. The atrophies were strictly linear. Ultrastructurally, collagen fibrils of the reticular dermis from the atrophic area consisted of two types, a large population of fibrils with decreased diameter and round cut-surface, and a small population with increased diameter and a "flower-like" cut-surface. Collagen analysis revealed a reduced hydroxyproline concentration and content per mm2 skin in atrophic area as compared with the perilesional and regional control. Urinary excretion of hydroxyproline was normal. Glycosaminoglycan analysis showed a less reduced content of hexosamine and uronic acid in the atrophic area per mm2 skin, but no differences in the concentrations. Consistently, the gel/fibre ratio (uronic acid/hydroxyproline) was found slightly elevated in atrophic skin. The proportions of the individual glycosaminoglycans heparin, dermatan sulphate, hyaluronic acid and chondroitin sulphates were not affected. It is concluded that reduced collagen and ultrastructural changes of collagen fibrils are significant features in local panatrophy. The significance of local foetal factors affecting the somatic mesoderm is discussed.

Adolescent↗
PubMed1982

Treponema pallidum in peripheral nerve tissue of syphilitic chancres.

Biopsies for electron microscopy were obtained from syphilitic chancres of 7 patients, 6 males and one female. In 4 of the patients, Treponemata pallida were seen gathering around peripheral nerves and invading the spaces between Schwann cells and their basal lamina. No definite degenerative changes were seen in the axons. In all patients, Treponemata pallida were gathering around the small blood vessels. The fine structure of Treponema pallidum in the lesions included a twined cytoplasmic cylinder with an inner and an outer lamina, an axial fibril consisting of three to five parallel filaments, each consisting of six microtubules, and a covering, outpouching periplastic membrane.

Adult↗
PubMed1982

65Zinc absorption in untreated and D-penicillamine-treated patients with generalized scleroderma: determination by whole-body counting technique.

65Zinc absorption in patients suffering from generalized scleroderma was studied by means of whole-body counting technique following a single dose of 65Zn. In 4 untreated patients the mean 65Zn absorption was calculated to 35% (range 20-59%). Five patients receiving oral D-penicillamine had a numerically higher mean absorption value of 55% (range 37-74%). The results corroborate earlier studies on the effect of D-penicillamine on 65Zn absorption in rats.

Administration, Oral↗
PubMed1982

Lichen aureus: a case report.

Lichen aureus (LA) is a distinctive, rare disease occurring predominantly in males, characterized by solitary rust- or copper-coloured patches of lichenoid micropapules, often present on fingers and calves. A case of LA in a 41-year-old male is presented. Biopsy revealed the characteristic pattern of LA, including a dense dermal infiltrate of lymphocytes and histiocytes containing haemosiderin. No epidermal changes were present.

Adult↗
PubMed1982

[Zinc deficiency dermatoses. Etiology, clinical aspects and treatment].

In zinc deficiency disorders the serum zinc concentration is low and the activity of alkaline phosphatase in serum is declining. The clinical picture includes a poor general condition and a characteristic dermatitis on hands, feet, in the face, and the anogenital region. In acute zinc deficiency, the eruption is vesico-bullous, in the chronic state parakeratotic psoriasiform. Widespread exzéme craquelée is an additional feature of the clinical picture, as seen in cirrhotics with acquired zinc deficiency. Alopecia, Beau lines on the nails, and hair changes may develop. In severe cases zinc therapy usually in the form of zinc sulphate may be administered i.v. (10-20 mg Zn daily). Oral zinc therapy is initially given in high doses (145-150 mg Zn daily). Long-term high zinc doses may interfere with copper metabolism and are only indicated for acrodermatitis enteropathica.

Acrodermatitis↗
PubMed1981

Hair changes due to zinc deficiency in a case of sucrose malabsorption.

A 7-year-old girl suffering from chronic diarrhoea due to sucrase deficiency was referred because of poor hair growth. Her scalp hair had a poor, colourless appearance and was much thinned in the occipital region. Her skin was dry, but otherwise normal. P-zinc was low (7.9 mumol/l), whereas P-albumin was normal. Oral zinc therapy, 40 mg daily, had a marked beneficial effect on her scalp hair, eyebrows and eyelashes, which became thicker and pigmented. Beau lines appeared on thumb-nails and 4th left finger-nail. A rise in P-zinc and S-alkaline phosphatase levels was observed during the zinc supplementation. Microscopic examination of her poor scalp hair, using polarized light, revealed well-defined abnormalities of the hair shafts, as reported by others in a case of acrodermatitis enteropathica: 1) a marked individual variation in diameter, 2) narrowing often associated with waving or sharp bending and broken ends, 3) striation with a tendency to trichonodosis. Such changes were absent in the pigmented hair appearing after the start of zinc therapy.

Alkaline Phosphatase↗
PubMed1981

[Granulomatosis disciformis chronica et progressiva (Miescher-Leder)].

A case of granulomatosis disciformis chronica et progressiva in a 75-year-old diabetic is reported. The dermatosis which was successfully treated with a high-potent local steroid preparation, today is regarded as a granulomatous variety of necrobiosis lipoidica. The present case shows, as originally described by Miescher and Leder, that the clinical findings as well as the histopathology represent an entity which may differ markedly from the common type of necrobiosis lipodica.

Aged↗
PubMed1980

Cromones in atopic dermatitis.

Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 microgram FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with atopic dermatitis. The weal and flare reaction was not reduced in the same patients when 1.5 mg of FPL 52758 was applied topically under occlusion for a 24-h period prior to challenge with antigen. The itch and slight pain caused by antigen injection was not experienced in the FPL 52758 pretreated areas. Preliminary clinical results were obtained with the cromone FPL 52757, but due to possible hepatotoxicity this trial was not completed. Another similar cromone without hepatotoxicity was used in a double blind within-patient study. Nine patients with mild to moderate atopic dermatitis were treated with FPL 57787 (5%) ointment and matching placebo ointment. No significant improvement was observed after 4 weeks of treatment with the cromone containing ointment.

Chromones↗
PubMed1980

Osmotic lysis of erythrocytes in relation to the zinc concentration of the medium.

The influence of various zinc concentrations on the osmotic resistance of erythrocytes was studied in six normal adults. Sodium chloride solutions ranging from 0.1% to 0.7% were prepared, each containing 0 microgram % zinc, 50 microgram % zinc, 100 microgram % zinc, 500 microgram %, and 1000 microgram % zinc. Heparin-stabilized venous blood was added to the various solutions at 25 degrees C, and the degree of haemolysis (erythrolysis) after 1 h was determined by measurement of the absorbance at 540 nm. Neither the absence, nor the presence of relatively high zinc concentrations were found to influence the degree of haemolysis. The results indicate that haemolytic anaemia which was observed in zinc-deficient patients is not due to a zinc-dependent change in the osmotic resistance of erythrocytes.

Adult↗
PubMed1980

Ultrastructural changes of zinc deficient rat epidermis: an electron microscopic study.

Zinc deficiency was produced in rats by feeding them a diet containing 0.5 mg zinc per kg. After 2 weeks the zinc-deficient rats showed markedly stunted growth as compared with control rats receiving an identical diet supplemented with 50 mg zinc per kg. After about 3 weeks all rats in the zinc-deficient group developed a greasy, coarse and scaly coat with dispersed, denuded, eczematous patches. After 32 days the animals were sacrificed and skin specimens were obtained from the abdominal area. Electron microscopy showed two different patterns of epidermal changes: (A) edematous cell bodies and cell organelles, degenerate nuclei, while desmosomes were well preserved: (B) parakeratotic and dyskeratotic cells with sparse keratohyalin granules, abnormal keratinosomes, poorly developed desmosomes, and disintegrated mitochondria in the upper part of the epidermis. In the lower part, keratinocytes contained numerous ribosomes and thick chromatin aggregates in the nuclei. Dendritic cells were disintegrated in pattern A, while they appeared normal in pattern B. In both patterns mitochondria showed vacuoles and a lack of DNA granules. A transient form of type A and B changes was also observed.

Animals↗
PubMed1980

Normal function of the thyroid gland in PUVA-treated psoriatics.

Ten psoriatics who were started on therapy with psoralen plus long-wave ultraviolet radiation (PUVA) were investigated for a possible influence of the treatment on the thyroid gland function. No statistically significant changes were found in the levels of serum thyroxine, triiodothyronine or thyrotropin obtained after 2 and 4 weeks' therapy and 3 months after cessation of therapy.

Adolescent↗
PubMed1980

Acquired zinc deficiency in alcoholic liver cirrhosis: report of two cases.

Acquired zinc deficiency in two patients suffering from alcoholic liver cirrhosis is reported. Skin changes included bullae and erosions on the heels, desquamating dermatitis on feet, hands and shins, and localized alopecia. Following oral zinc therapy the skin changes disappeared and Beau lines were later seen on the finger nails. Concomitantly with the rise in the depressed plasma zinc levels, serum alkaline phosphatase and prothrombin levels rose and serum bilirubin decreased. The observations are in agreement with earlier reports dealing with congenital and conditioned zinc deficiency and oral zinc therapy in alcoholic liver cirrhosis.

Humans↗
PubMed1980

Prevalence of skin diseases in old age.

The prevalence of skin disorders was studied in an elderly population comprising 584 individuals. The mean age was 80 years (range 55-106). The prevalence of pityriasis of the scalp and asteatosis was high, 44.3% and 28.9%, respectively. Psoriasis vulgaris was found in 2.9%, vitiligo in 1.2%, and contact dermatitis in 3.8% of the group.

Aged↗