Type A as a challenge-induced response: two-year follow-up.
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Biomedical subjects
Publications and source records attributed to K V Jones.
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In 1978, the second-year pre-clinical Behavioural Sciences course at Monash University Medical School was restructured to improve monitoring of, and feedback on, the development of interpersonal relationships between individual students and individual old age pensioners they were studying. Results indicate that integration of lecture, discussion, and practical experience with a carefully defined, multistage project appears to help students in learning about interpersonal relationships, and helps staff to evaluate both student performance and teaching.
In 75 schoolgirls aged 5-11 with untreated covert coliform bacteriuria who were followed up to 4 years, infection cleared in 16 (21%), cleared and recurred in 37 (50%) and persisted in 22 (29%). Clearance of bacteriuria was significantly (P less than .05) more frequent in girls with normal radiological findings than in those with abnormal findings. In 31 (59%) of the 53 girls in whom bacteriuria cleared spontaneously, the urine became sterile within the first year after the discovery of the bacteriuria. Spontaneous clearance of bacteriuria was preceded by an increase of the sensitivity of the urinary pathogens to the cidal effect of human serum. Seven (10%) of the 75 untreated bacteriuric girls had shown progression of kidney damage (progression of scarring in 4 and failure of kidney growth in 3). In all of these 7 girls vesico-ureteric reflux (VUR) was present and bacteriuria was persistent, but in 6 of them from one to three changes in the serotype of Esch. coli or bacterial species were noted during follow-up. These observations suggest that changes in bacterial flora may be a risk factor in the progression of kidney damage in girls with urinary tract infection and VUR.
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The aim of this study was to validate the empathy scale (Hogan, 1969) for use in the context of medical education in Australia. Empathy Scale scores of students in their first clinical year at Monash University were correlated with patient ratings, self ratings, and peer ratings of empathy. Inter-rater and intra-rater reliability were assessed. Correlations were also obtained between Empathy Scale scores and course marks in psychiatry. Of the empathy ratings only those by peers correlated significantly with Empathy Scale scores (r = 0-45, P less than 0-05, n = 29). Empathy Scale scores were unrelated to academic performance. In a separate part of the study, not connected to the establishing of criterion-related validity, Empathy Scale scores of the medical student group were found to be significantly higher (t=4-44, df = 52, P less than 0-001) than the scores of psychiatric patients with a diagnosis of "personality disorder". This study provides some support for the Empathy Scale as a measure of interpersonal effectiveness, but has not established it as a valid measure of empathy in a clinical setting.
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5 Male children exhibiting the typical features of the Prune-Belly syndrome (malformations of the urogenital tract, aplasia of abdominal muscles) are described. Two of these are deaf. This syndrome has also been observed in a few females. Final interpretation of the cause and pathogenesis cannot yet be given. In two siblings with defects of the abdominal muscles an contractures of the joints, but without renal anomalies, a new and hitherto undescribed hereditary syndrome seems to be present.
A method of lyophilizing influenza virus in allantoic fluid with retention of high-titer of egg infectivity is described. Five strains of virus were lyophilized, and all were much more stable than fluid virus preparations, retaining 2 to 3 logs of infectivity after storage at 37 C for 60 to 95 days. Statistical analysis of an accelerated storage test by extrapolation of viral degradation indicates that the lyophilized viruses are stable indefinitely at or below room temperature.
Serum is commonly treated with potassium periodate to destroy nonspecific inhibitors of influenza virus hemagglutination. We have observed, however, that such treatment of serum without pre-existing inhibitor produced high titers of inhibitor against certain strains of influenza virus. Inhibitor was induced in the serum from several different animal species but not in hamster or mouse serum. Periodate treatment of serum albumin, fraction V, from several animals, including man, creates this inhibitor. Our data indicate that the inhibitor induced in the serum of various animal species differs in its mechanism of induction and in its resistance to receptor-destroying enzyme and trypsin. Hemagglutination by B/Singapore/3/64, B/Colorado/2/65, B/Georgia/1/65, and B/Massachusetts/3/66 strains of influenza virus is inhibited by periodate-treated human serum at dilutions as high as 1:5,120. The routine use of periodate treatment of serum in diagnostic and surveillance studies of influenza virus infections is not recommended.