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Biomedical subjects

K Uematsu

Publications and source records attributed to K Uematsu.

At least 91 records · Page 5Linked to original sources
PubMed1988

[Metastatic renal tumor originating from esophageal carcinoma: a case report].

A 46-year-old woman with a past history of esophageal carcinoma was hospitalized with the chief complaint of right abdominal pain. Enhanced computed tomography (CT) and selective renal angiography suggested a metastatic renal tumor. Right nephrectomy was performed. Histological examination revealed a renal tumor originated from esophageal squamous cell carcinoma. Metastatic renal tumors are frequently observed at autopsy, but clinically they are extremely uncommon. Thirty-four clinical cases of metastatic renal tumors reported in the Japanese literature during these 20 years are discussed including the present case.

Esophageal Neoplasms↗
PubMed1987

A primary lung carcinoma producing alpha-fetoprotein, carcinoembryonic antigen, and human chorionic gonadotropin. Immunohistochemical and biochemical studies.

This article documents a patient with lung carcinoma that produced three oncofetal antigens including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and human chorionic gonadotropin (hCG). Serum AFP, CEA, and hCG-beta-subunit were extremely high--118,000 ng/ml, 133 ng/ml and 0.9 ng/ml, respectively. Immunohistochemical staining of these tumor markers revealed that these proteins were present in different cells. The pattern of lectin affinity electrophoresis of AFP resembled that of hepatocellular carcinoma. Also investigated was the reactivity of serum CEA to monoclonal antibodies against peptide or sugar moieties. Serum CEA values measured by antipeptide monoclonal antibodies were higher than those measured by antisugar monoclonal antibodies. The demonstration of AFP, CEA, and hCG in different tumor cells suggests that three genomes were not reactivated together in a cell, and the lung carcinoma probably consisted of at least three clones of cancer cells with different phenotypes.

Antibodies, Monoclonal↗
PubMed1985

Acromegaly associated with suprasellar and pulmonary hemangiopericytomas. Case report.

The authors report the case of a 35-year-old acromegalic woman who developed amenorrhea and decreased left vision, and who was found to have suprasellar and pulmonary hemangiopericytomas. Total removal of the suprasellar hemangiopericytoma resulted in normalization of the plasma human growth hormone (GH) level and a marked decrease in size of the pulmonary hemangiopericytoma. Immunoperoxidase studies for GH and human hypothalamic growth hormone-releasing factor (GHRF) demonstrated immunoreactive intracellular GH only in the suprasellar hemangiopericytoma, with no immunoreactive intracellular GHRF evident in either the suprasellar or pulmonary hemangiopericytoma.

Acromegaly↗
PubMed1985

[Separation of HT and HTO in the atmosphere with porous Vycor glass tube].

The continuous selective monitoring of tritium gas (HT) in the air containing HT and tritiated water vapor (HTO) was investigated by using the separation cell made of porous Vycor glass tube. On admitting the air containing HT or HTO into the separation cell, HT permeated immediately through the Vycor tube depending on the partial pressure, however, HTO permeated very slowly through the Vycor tube after initial induction period. The initial induction period was elongated with a rise of the temperature of separation cell and then the permeability of HTO decreased remarkably. In the air containing HT and water vapor, the permeation of HT through the Vycor tube was considerably restricted by the water vapor adsorbed on the Vycor tube at lower temperature (at 25 degrees C) but it was hardly affected by water vapor at higher temperature (greater than 50 degrees C) since water vapor was difficult to adsorb on the Vycor tube. These results indicated that HT in the air containing HT and water vapor can be continuously monitored by using the separation cell made of the porous Vycor glass tube.

Air Pollutants↗
PubMed1984

Malignant histiocytosis in the oropharynx.

Malignant histiocytosis is characterized by systemic, progressive, and invasive proliferation of malignant histiocytes. The disorder is typically accompanied by fever, general fatigue, lymphadenopathy, and hepatosplenomegaly. A case of a 21-year-old woman with primary malignant histiocytosis of the oropharynx is reported. Histologic diagnosis from the biopsy specimen was confused by infiltration of normal-appearing histiocytes and inflammatory cells. The titers of Epstein-Barr virus and the Paul-Bunnell test were elevated without atypical lymphocytes. The patient died 3.5 months after the onset of symptoms. Autopsy revealed systemic neoplastic proliferation of malignant histiocytes. A review of literature on this subject revealed no cases of malignant histiocytosis primarily involving the oropharynx.

Adult↗
PubMed1984

Somatostatin-like immunoreactivity in rat thyroid. Age-associated S-cell hyperplasia.

Somatostatin-like immunoreactive cells of the rat thyroid gland at various ages were investigated immunohistochemically. The number of cells per lobe in 5 micron sections increased with age. Immunopositive cells were evident as small clusters in the older age group (8 to 24 months old) but not clustered in the younger age group (3 to 5 months old). This type of proliferation was termed S-cell hyperplasia in a manner similar to C-cell hyperplasia observed in the aged rat thyroid.

Aging↗
PubMed1984

Malignant pheochromocytoma with ACTH production.

An autopsy case of a 54-year-old woman with malignant pheochromocytoma and ectopic ACTH production was reported. Noradrenaline was increased in 24 hour urine and in the blood sample from the left adrenal vein. Hormone assay studies of the tumor tissue and plasma revealed abnormally high levels of ACTH. Formaldehyde fume induced fluorescence method demonstrated biogenic amine in the tumor cytoplasm. Electron microscopic examinations also disclosed numerous neurosecretory granules in the tumor cytoplasm. These findings confirmed that this pleomorphic carcinoma of the left adrenal gland was one of the APUDoma originating from the adrenal medulla, so-called pheochromocytoma.

Adrenal Gland Neoplasms↗
PubMed1984

Non-papillary carcinoma in situ of the urinary bladder. An electron microscopic study.

A case of non-papillary carcinoma in situ of the urinary bladder was presented with ultrastructural descriptions. Dysplastic urothelial cells had a large nucleus with prominent nucleoli and increased euchromatin. The nuclei had a wavy outline with irregular invaginations. Cytoplasmic organella were immature and fairly good amount of glycogen particles existed in the cytoplasm. Among the dysplastic cells, there are two types of epithelium, one which has irregular pleomorphic cytoplasmic processes and the other which has relatively smooth cell borders. Both types had few poorly developed desmosome-like cell attachments and wide intercellular space. This study revealed that decreased numbers of desmosome-like attachments and wide intercellular space with or without cytoplasmic processes of non-papillary transitional cell carcinoma of the urinary bladder might be a morphologic expression of loss of cohesiveness in this type of carcinoma.

Aged↗
PubMed1984

Primary C cell hyperplasia of the thyroid in Fischer 344 rats. An immunohistochemical study.

C cell proliferation of the thyroid, which was designated as primary C cell hyperplasia (PCCH), was demonstrated in aged Fischer 344 rats in high incidence using the immunohistochemical method for calcitonin. It developed from mild to severe PCCH and resulted in nodular PCCH and tumor formation. The combined incidence of PCCH and nodular PCCH was increased with age and appeared in 60.7% of 7-15 month old group and 92.7% of 16-24 month old group possibly as a preneoplastic C cell lesion. It is almost an equivalent C cell lesion reported in the human thyroid with familial C cell carcinoma and therefore this Fischer 344 rat can provide a useful animal model to study familial C cell tumor of the thyroid.

Animals↗