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Biomedical subjects

K Ueda

Publications and source records attributed to K Ueda.

At least 1,729 records · Page 96Linked to original sources
PubMed1977

The chemical mediation of delayed hypersensitivity skin reactions. I. Purification of a macrophage-chemotactic factor from bovien gamma-globulin-induced skin reactions in guinea pigs.

A macrophage-chemotactic factor (MCFS) was extracted in the pseudoglobulin fraction from delayed hypersensitivity skin lesions induced by bovine gamma-globulin in guinea pigs. Its chemotactic activity was estimated by a modification of Boyden's method using Nuclepore filter. After chromatography of the protein fraction using Sephadex G-50 and DEAE-cellulose, in that order, two chemotactic fractions were obtained. The chemotactic factor with stronger activity (MCFS-1) was further highly purified (488-fold) by chromatography on CM-Sephadex. This factor migrated in a single band on acrylamide disc gel electrophoresis and was found to be a protein that was free of nucleic acid. Gel filtration showed that its molecular weight was similar to that of IgG. Its chemotactic activity was heat labile. Intradermal injection of this factor into normal guinea pigs induced a pronounced mononuclear cell emigration from venules. These findings are pertinent to understanding macrophage reaction in the delayed hypersensitivity reactions. Am J Pathol 87:359-374, 1977).

Animals↗
PubMed1976

Cell wall development of Micrasterias americana, especially in isotonic and hypertonic solutions.

The cell wall development of Micrasterias americana was investigated by light and electron microscopy. From digestion experiments with pectinase and cellulase, and from fluorescence spectra in Calcofluor and Coriphosphin solution, it was concluded that pectin substances were the main component of the young developing cell wall and that cellulose was synthesized after the daughter hemicell was well developed. In 0-16 M mannitol, wall materials accumulated and were incompletely incorporated into the wall at the region where wall growth would be expected. The plasma membrane was in close contact with the cell wall at the sinus, and this contact was assumed to prevent penetration of wall material at this region, resulting in the accumulation of wall material at regions other than the sinus. The cellulosic wall layer was formed after the production of pectic substances in the 0-16 M mannitol. In 0-3 M mannitol neither a definite wall layer of cellulose nor a pectic wall was produced, presumably due to extensive dilution of the wall materials in the plasmolysed space between the cell wall and the plasma membrane. Under normal circumstances, the shape of the daughter cell is assumed to be determined by the shape of the developed primary wall, which is induced by precocious differentiation of the wall at the sinus.

Cell Membrane↗
PubMed1976

A clinicopathological study on the electrical axis of the heart in 1,000 autopsy cases.

The electrical axis of the heart in 1,000 aged people more than 56 years of age was classified as normal axis in 58%, left axis deviation in 17.4%, mild left axis devaition in 21.9%, and right axis deviation in 2.7%. Pathological examination disclosed that left axis deviation was associated with myocardial infarction in 20%, right bundle branch block in 16%, but showed no significant relationships with coronary sclerosis, myocardial fibrosis and cardiac hypertrophy. Right axis deviation was associated with right bundle branch block in 66.7% and right ventricular hypertrophy in 22.2%

Aged↗
PubMed1976

A case of tumor embolism of the coronary artery, resulting in myocardial infarction and cardiac rupture.

A case of tumor embolism of the coronary artery in a 78-year-old woman was presented. The tumor embolus originating from cancer of the breast resulted in massive large myocardial infarction in the lateral wall of the left ventricle, and she died of cardiac rupture. Metastatic lesions were found in the bilateral lungs, the endocardial and subendocardial layers of the left ventricle, with a growth of tumor thrombus into the left atrium, and also other extracardiac organs.

Aged↗
PubMed1976

Sinus node recovery time and abnormal postpacing phase in the aged patients with sick sinus syndrome.

The sinus node function was evaluated by rapid atrial pacing in 35 aged patients (mean age 78.2 years) including 10 aged controls, 12 cases with various degrees of AV block, 6 with bradycardia-tachycardia syndrome (BTS), and 7 with sinus bradyarrhythmia (SB). AV block was further divided into A-H block (7 cases) and H-V block (5 cases) by His bundle electrogram which was simultaneously recorded with 3 leads of surface electrocardiogram. Sinus node recovery time (SRT) was measured and its maximum value (SRTmax) was selected from SRTs obtained after pacing with various rates and durations in each patient. SRTmax was also expressed as percentage of the control P-P interval (%SRTmax). For patients in whom the study was repeated 3 to 8 months later, %SRTmax was reproducible in 9 of 14 instances. Prolongation of SRT was not always observed as the rate and/or duration of pacing was increased. SRTmax and %SRTmax were 1,363 +/- 188 msec and 147 +/- 19% (mean +/- SD), respectively, for aged controls, 1,597 +/- 442 msec and 156 +/- 31% for patients with AV block, 2,087 +/- 1,315 msec and 203 +/- 132% for those with BTS, and 3,069 +/- 1,287 msec and 247 +/- 115% for those with SB. SRTmax exceeding the range for aged controls was noted in 4 of 7 cases (57%) with A-H block, 2 of 6 (33%) with BTS, and 5 of 7 (71%) with SB; normal SRT was not infrequently observed in patients with sick sinus syndrome, especially in those with BTS. Analysis of 10 consecutive atrial cycles following cessation of pacing revealed that in 8 cases the first P-P interval (SRT) was followed by longer ones in some occasions (secondary suppression). It was observed almost exclusively in patients with sick sinus syndrome. The possibility of this phenomenon to reflect another feature of sinus node abnormality was discussed.

Aged↗
PubMed1976

A clinicopathological study on the sick sinus syndrome.

A total of 6 cases of sick sinus syndrome were presented, including 2 cases of sinoatrial (SA) block and 4 cases of bradycardia-tachycardia syndrome. There were 2 men and 4 women, and their ages ranged from 69 to 91 years. Electrophysiological studies were performed in 3 cases, showing positive overdrive suppression in 1 and normal atrioventricular (AV) conduction in 3. Syncopal attacks were found in 4 cases, and 2 cases died suddenly. Histological examination of the SA node and AV conduction system disclosed (1) marked reduction of the SA nodal muscle fibers by 70 t0 80%, (2) moderate to marked proliferation of connective tissues in the SA node, and (3) moderate fibrosis in part of the left bundle branch. The SA node artery was patent.

Aged↗