Search PubMed⌕ Search

Biomedical subjects

K Ueda

Publications and source records attributed to K Ueda.

At least 1,621 records · Page 90Linked to original sources
PubMed1979

A clinicopathological study on 25 cases of complete left bundle branch block.

A total of 25 cases (12 men, 13 women) of complete left bundle branch block (LBBB) were found among 1,400 consecutive autopsy in the aged. Their ages ranged from 70 to 86 years (average 78.9). ECG was analyzed as for the occurrence of LBBB and myocardial infarction (MI). Pathological examinations included observations of the conduction system by serial sections. They were divided into group A with MI and group B without MI. Duration of LBBB was 1 to 3 days in 4 cases, more than 1 month in 7, and more than 1 year in 14. From the temporal sequence of LBBB and MI in group A, cases were classified into (1) MI preceding LBBB in 5, (2) both coexistent in 5, and (3) LBBB preceding MI in 1. There were 8 cases of normal electrical axis, 17 left axis deviation, 7 first degree A-V block, and 2 atrial fibrillation. Various heart diseases were underlying in 21 cases, including hypertension, MI, mitral and aortic regurgitation, and primary myocardial disease, and there were 4 cases with no cardiac diseases. Cause of death was cardiac in 12; MI, congestive heart failure, and sudden death. Heart weight was 410 Gm on the average (240 to 550 Gm). MI was found in 11, with stenotic index of 12/15, while it was 9/15 in group B. Lesions of the conduction system were slight to moderate (1.5 to 2.4) except left bundle branch, which showed marked changes in posterior (4.9) and anterior (4.8) fascicles. Site of interruption of the left bundle branch was the junction between the branching portion of the A-V bundle and the left bundle branch (Junctional type) in 17, and peripheral portion of the left bundle branch about 10 mm or more below the junction in 8 (Peripheral type). In conclusion, 2/3 of cases of LBBB belonged to the junctional type and most of them were not related to MI, but to the lesions caused by mechanical injuries at the septal summit. One third of the cases were as peripheral type, which was mainly related to the various types of lesions including septal ischemia (necrosis and fibrosis).

Aged↗
PubMed1979

Effect of alpha-tocopherol on the binding of benzo(a)pyrene to nuclear macromolecules.

The binding of metabolically activated 14C-benzo(a)pyrene (BP) to rat liver nuclei was studied. The nuclear framework structure, termed the nuclear matrix, was found to bind BP preferably. alpha-Tocopherol inhibited the binding of BP to nuclear macromolecules in the presence of phenobarbital (PB)-induced microsomes. alpha-Tocopherol decreased the level of BP metabolites in nuclei, though it did not inhibit the activation of BP by PB-induced microsomes.

Animals↗
PubMed1979

Response of athymic nude mice to Sendai virus.

Athymic nude mice and euthymic litter mates with BALB/cA back-ground were infected intranasally with a strain of Sendai virus. While no severe illness occurred in euthymic litter mates, some of nude mice showed marked body weight loss and died within 3 weeks after infection. The remaining nude mice recovered from the early depression and survived for 6 weeks or more with chronic pulmonary lesions. The virus was demonstrable in lungs of these chronic cases up to 10 weeks after infection, and none of infected nude mice were found to have anti-Sendai virus antibodies. Pulmonary lesions were characterized by diffuse interstitial pneumonia with a high incidence of prominent adenomatous metaplasia of alveolar epithelium.

Animals↗
PubMed1979

The prognostic value of serum immunosuppressive effect in patients with ovarian cancer.

Sixteen patients who underwent surgery and postoperative chemotherapy for carcinoma of the ovary were studied. Eleven survived more than 18 months without evidence of recurrence, and 5 died more than 5 months after surgery. Serial determinations were made preoperatively and postoperatively of the immunosuppressive effect of the serums of these patients on the response of normal lymphocytes to phytohemagglutinin stimulation. These determinations were plotted for each patient; the shapes of the curves for patients who survived are markedly different from those of patients who died. The prognostic value of these findings is discussed.

Adult↗