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Biomedical subjects

K Ueda

Publications and source records attributed to K Ueda.

At least 1,495 records · Page 83Linked to original sources
PubMed1982

Secondary type V hyperlipoproteinemia in an acromegalic patient without overt diabetes.

A rare case of acromegaly developing gross hyperlipidemia not associated with overt diabetes was presented. Gross hyperlipidemia revealed type V hyperlipoproteininemia, according to agarose gel electrophoretic pattern of serum lipoprotein. Before pituitary surgery, the serum levels of cholesterol and triglyceride were 320 mg/dl and 1830 mg/dl respectively, and the basal level of growth hormone was markedly elevated, ranging from 129 to 231 ng/ml with the mean +/- SD of 168 +/- 39 ng/ml. The enzymatic activities of hepatic triglyceride lipase (H-TGL) and lipoprotein lipase (LPL) were 14.2 and 1.50 mumoles/ml/hour, respectively. H-TGL activity was normal, while LPL activity was extremely low compared to those of normal subjects. After combined therapy with pituitary surgery and 60Co radiation, the serum level of growth hormone was decreased to 35.9 +/- 8.6 ng/ml in the mean +/- SD, but not normalized. However, the serum level of triglyceride was decreased and both H-TGL and LPL activities were increased to 19.3 and 2.7 mumoles/ml/hour, respectively. LPL activity was increased 79% compared to the level of pretreatment. Agarose gel electrophoretic pattern of lipoprotein changed from type V to type IV and ultracentrifugal analysis showed that very low density lipoprotein (VLDL)-cholesterol was decreased and intermediate density lipoprotein (IDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and high density lipoprotein (HDL)-cholesterol were increased.

Acromegaly↗
PubMed1982

The chemical mediation of delayed hypersensitivity skin reactions: III. Purification and characterization of a precursor protein for macrophage-chemotactic factor in normal guinea pig plasma.

A putative precursor protein for macrophage-chemotactic factor, which was extracted fro inflammatory skin sites (MCFS-1) (Kambara et al, Am J Pathol 1977, 87:359-374), was found in normal guinea pig plasma and was purified to an apparent homogeneity upon SDS-polyacrylamide gel electrophoresis with a molecular weight of 160,000. This plasma protein was different from complement components of C3 and C5 in terms of molecular weight, functional activity as complements detected by hemolytic assay, and immunologic properties. Although it exhibited the common antigenicity with MCFS-1, it did not show any chemotactic activity for macrophages, However, incubation of this plasma protein at either 4 C for 5 days or 37 C for 1-2 days could generate a chemotactic factor with a molecular weight of approximately 150,000 which was similar to that of MCFS-1. This generation of chemotactic activity was completely prevented by the presence of the serine-type protease inhibitor, phenylmethylsulfonyl fluoride. These data could be well accounted for if we assume that this plasma protein might be a precursor for the macrophage-chemotactic factor found in delayed hypersensitivity skin sites, and that a proteolytic process might be involved in the activation of this precursor.

Animals↗
PubMed1982

[A correlative study of M-mode echocardiograms and pathological findings in mitral ring calcification].

Correlation between pathologically proved mitral ring calcification (MRC) and M-mode echocardiographic findings was examined. Subjects for this study were 36 aged autopsy cases of MRC (14 men, 22 women) with a mean age of 78.9 years. Echocardiographic diagnosis of MRC was based upon the following criteria; a dense echo that moves parallel to the endocardium of the left ventricular posterior wall, immediately posterior to the mitral leaflet and its abrupt termination during a sweep of the beam to the left atrium and left ventricle. The length along the mitral ring and its maximal cross-sectional diameter of MRC were measured pathologically. Extension of MRC to the mitral commissures was also evaluated. The following results were obtained; (1) The larger was the size of MRC measured pathologically, the more it was easily diagnosed by echocardiography. (2) The width of MRC in the echocardiogram correlated well with the pathologically measured maximal cross-sectional diameter of MRC (r = 0.67, p less than 0.01). (3) Sensitivity in the diagnosis of MRC was better in the echocardiograms (58.3%) than in the plain chest X-ray films (38.9%) (p less than 0.05). The length of MRC equal to or greater than 30 mm was diagnosed in all by the echocardiograms. In contrast, only 78.6% of these were diagnosed by plain X-ray films. (4) When cases with MRC were divided into 2 groups according to the mitral diastolic descent rate (MDDR), the decreased group (MDDR less than 35 mm) had a significantly longer length of MRC (32.4 +/- 15.5 mm) than the non-decreased group (16.6 +/- 20.9 mm) (p less than 0.05). Extension of MRC to the mitral commissures was more frequently observed in the group with decreased MDDR than in non-decreased group (p less than 0.005). From these observations, it was suggested that mechanical restriction of the movement of the anterior mitral; leaflet due to involvement of the commissures by MRC may be a contributing factor for decreased MDDR. (5) Identification of echoes from the posterior mitral leaflet and the left ventricular posterior wall was difficult in cases with positive MRC echoes.

Aged↗
PubMed1982

Subacute sclerosing panencephalitis. An autopsy case with impaired cellular immunity.

An autopsy case of subacute sclerosing panencephalitis (SSPE) in a 5-year-old boy, with rapid progression to a comatose state in 2 weeks after the onset of right hemiplegia, is described. The levels of antibody to measles virus in the serum and the cerebrospinal fluid were increased, and high levels of IgG in the latter were found. A characteristic pattern of electroencephalogram (EEG) showing periodic suppression of high voltage complexes was also found during the course of the disease. Microscopical examination revealed perivascular cuffing, numerous hypertrophied astrocytes with a diffuse gliosis and sporadic intranuclear inclusions in the brain. In addition to these typical findings of SSPE, impaired cellular immunity was recognized by delayed skin test in vivo, and pathologically severe atrophy of thymus, and follicular atrophy of spleen with amyloid deposition in the wall of the sheathed arteries were found.

Antibodies, Viral↗
PubMed1982

Humoral immunity following double freezing of the prostate of patients with prostatic cancer.

In these studies, double freezing of the prostate was applied to 10 patients with a confirmed histologic diagnosis of stage C and D carcinoma. The clinical courses in the first group (five patients) were favorable. In the second group (two patients), death by cachexia occurred due to the cancer. In the third group (three patients), death 4 weeks after the second cryosurgery suggests the effects of Cryoshock. In the first and second groups, the results of immunologic examinations after the second freezing did not attain the predicted levels. Comparing the results of the third group with those of the first and second groups, the primary difference was that the percentages of gamma globulins and IgE were higher in the third group preoperatively. These findings suggest that in patients with high gamma globulin percentages and high IgE levels cryosurgery of the prostate is contraindicated.

Acid Phosphatase↗
PubMed1982

Two-dimensional echocardiographic visualization of the peripheral right coronary artery in patients with mucocutaneous lymph node syndrome.

New two-dimensional echocardiographic techniques to visualize the proximal, mid and distal portions of the right coronary artery (RCA) and posterior descending artery were described in patients with mucocutaneous lymph node syndrome (MCLS). The proximal portion of the RCA was imaged by modified apical approach, and its length was longer than that by the conventional parasternal method. This artery was detected in all patients. The mid portion of the RCA was detected by directing the transducer to the right from parasternal window. Adequate visualization of this portion was obtained in 78 percent of patients. To image the distal portion of the RCA, the transducer was directed inferiorly from the parasternal four-chamber view. Adequate imaging of this portion was possible in all. The posterior descending artery was examined by tilting the transducer inferiorly after obtaining the parasternal long-axis view. In 56 percent of patients, a sufficient echogram was not obtained. Validity of these methods was confirmed by reasonable agreement between two-dimensional echocardiographic and coronary angiographic findings. Using these approaches, no peripheral aneurysm was missed by two-dimensional echocardiography. New approaches are useful in evaluating the RCA in patients with MCLS, and are also recommended to evaluate the RCA in other disorders.

Aneurysm↗
PubMed1982

A study on the effects of niludipine in hypertensive patients.

Niludipine (Bay a 7168), a newly developed Ca2+-antagonist, was administered to eight aged patients with moderate to severe hypertension in order to study the antihypertensive effects and duration of action of a single dose as well as to evaluate the long-term effects. The subjects in the present study consisted of eight hypertensive, hospitalized patients (four men and four women, average age 74.6 years). After a two-week control period niludipine was administered in doses of 60 or 120 mg daily for five consecutive weeks (drug period) and, then, placebo tablets were administered in the same number of tablets as that of the drug for one week. On the first day of the treatment period, the drug was administered three times in a dose of 20 mg each, and the blood pressure and pulse were measured for 10 h after the administration. The systolic blood pressure was significantly reduced in the second and subsequent weeks of the treatment period, while the diastolic blood pressure was reduced only in the fourth week (P less than 0.05). During the placebo period, the blood pressure was elevated again. No side-effects were noted. In the single dose study, the systolic blood pressure was significantly reduced within 4 h after the administration, reaching its lowest value after 6 h, and tended to return to the pretreatment level after 10 h.

Aged↗