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Biomedical subjects

K Ueda

Publications and source records attributed to K Ueda.

At least 1,459 records · Page 81Linked to original sources
PubMed1983

[Report on 15 cases of multiple primary cancers in our department].

Of 512 gynecological malignant cases treated in our department, 22 were suspected of multiple primary cancer; 15 were confirmed by clinical and pathological findings, representing an incidence of 2.9% (15/512) of all malignant cases. The most frequent sites of other cancers in patients with cervical cancer were intestinal (5/15), mammary (3/15) and urinary (2/15). Nine (60%) of 15 multiple primary cancers were noted within 12 months. Two rare combinations are also reported. There was a patient with Grawitz's tumor (kidney) and epidermoid cancer (uterine cervix) and one with leiomyosarcoma (uterine corpus) and epidermoid cancer (uterine cervix).

Aged↗
PubMed1983

Macular involvement in morning glory syndrome.

Clinical features of morning glory syndrome were studied in 8 eyes of 7 patients. The cases were divided into two groups according to the size of the elevated peripapillary white ring. The size of the ring was expressed as an average disk diameter of normal control eyes. In 2 eyes of Group I with the ring less than 2.0 disk diameters, white tissue on the disk was less pronounced than in Group II, and vascular pattern in the posterior retina was almost normal. The macular ring reflex was present. In 6 eyes of Group II with the ring exceeding 2.0 disk diameters, white tissue on the disk was more marked than in Group I, and retinal vessels were narrow and extended straight toward the midperiphery. the macula was not formed, but a yellowish retinal area was observed on the center or temporal part of the elevated peripapillary white ring. It was concluded that in morning glory syndrome the macula may often by involved when anomaly of the optic disk is remarkable.

Adolescent↗
PubMed1982

Paradoxical anti-leukemic effects of plant-derived tumor promoters on a human thymic lymphoblast cell line.

Three different diterpen polyols and the teleocidin have antileukemic effects on the human thymic leukemia cell line HPB-ALL by inducing phenotypic differentiation. We tested TPA (phorbol esters), mezerein (daphnane), milliamin (ingenol ester) and teleocidin B (teleocidins) as representative of the chemical structure of each principle and found that these agents have the similar biological activity of inducing phenotypic differentiation in HPB-ALL cells. Moreover, competitive binding of [3H]PDB to cell-surface receptors was significantly inhibited by these agents; n-butyrate and phorbol per se did not inhibit the binding of [3H]PDB. Despite differences in the structure of the principles, these agents may have similarly acting side-chain structures.

Alkaloids↗
PubMed1982

Aortography by countercurrent injection via the radial artery in infants with congenital heart disease.

Aortography by countercurrent injection into the radial artery as performed for analysis of aortic arch anomalies in 12 infants with congenital heart disease. Eleven aortograms were obtained without complications, but one failed. Coarctation of the aorta, patent ductus arteriosus, aberrant origin of the right subclavian artery, interrupted aortic arch, anomalous origin of the right pulmonary artery from the ascending aorta, and hypoplastic ascending aorta were demonstrated by this method. Patency of the reconstructed aortic arch was confirmed in the postoperative study of the case of interrupted aortic arch. Aortography by countercurrent injection via the radial artery affords an easy, safe, and simple bedside means for analysis of aortic arch anomalies without retrograde arterial catheterization. The latter is occasionally complicated by thrombosis of the artery in small infants.

Aortography↗
PubMed1982

Hemodynamic effects of salbutamol, an oral long-acting beta-stimulant, in patients with congestive heart failure.

As the efficacy of oral long-acting sympathomimetic drugs is not yet well established, we investigated the hemodynamic effects of orally administered salbutamol in eight heart failure patients. Cardiac index, heart rate, blood pressure, and left ventricular filling pressure were monitored for 6 hours after a single oral administration of 4 to 8 mg salbutamol and placebo. In patients who had received salbutamol, a 40% increase in the cardiac index (+0.75 L/min/m2, p less than 0.01) was noted 1 hour post administration; a 44% increase (peak effect) occurred at 2 hours (+0.84 L/min/m2, p less than 0.05); and a significant increase persisted for 6 hours. Changes in heart rate showed a similar time course; however, the increase was less pronounced (+27% at 2 hours). The changes in blood pressure were slight and none of the eight patients developed ventricular arrhythmia or other complications. After placebo administration, no consistent changes in the hemodynamic parameters were noted. The present study suggests that, due to its sustained positive action on cardiac output, the oral administration of salbutamol may be efficacious in ambulatory patients with low cardiac output due to heart failure.

Administration, Oral↗
PubMed1982

Humoral immunity following double-freezing of the prostate in patients with prostatic cancer.

In these studies, 10 patients with a confirmed histological diagnosis of stage C and D carcinoma underwent double-freezing of the prostate. The clinical courses in the first group (five patients) were favorable. In the second group (two patients), death by cachexia occurred due to the cancer. In the third group (three patients), death 4 weeks after the second cryosurgery suggests the effects of cryoshock. In the first and second groups, the results of the immunological examinations after the second freezing did not attain the predicted levels. Comparing the results of the third group with those of the first and second groups the primary differences was that the percentages of gamma-globulins and IgE were higher in the third group preoperatively. These findings suggest that patients with high percentages of gamma-globulin and high IgE levels are contraindicated for cryosurgery of the prostate.

Adenocarcinoma↗
PubMed1982

The relationship of serum uric acid to hypertension and ischemic heart disease in Hisayama population, Japan.

The association of serum uric acid (SUA) with hypertension, ischemic ECG change, diabetes mellitus, and drinking and smoking habits was studied by multivariate analysis among 1871 residents aged 40 and over in Hisayama, Japan. Blood pressure level and history of hypertension did not correlate with an increased level of SUA when other factors such as serum creatinine, obesity, beta-lipoprotein and leucineaminopeptidase were taken into account. Antihypertensive medication was a significant factor influencing SUA. The association of SUA with Minnesota code 4.1-3 (S-T depression) was insignificant in men and significant in women when other factors influencing SUA were taken into account. Glycosuria was negatively correlated with SUA, while alcohol ingestion has positive correlation. There was no correlation between the amount of tobacco smoked and the level of SUA.

Alcohol Drinking↗
PubMed1982

Properties of T antigen-positive phenotypic revertants isolated from SV40-transformed rat and mouse cells.

Four T antigen-positive phenotypic revertants were isolated by negative selection with BUdR from SV40-transformed rat and mouse cells which contain six and two viral genome equivalents per cell, respectively. Karyological analysis indicated that one rat and one mouse revertant had a hyperploid number of chromosomes, while the remaining two rat revertants had a subtetraploid number similar to those of the transformed parent cells. The hyperploid revertants were unable to grow in soft agar medium and were nontumorigenic in nude mice. One of the subtetraploid revertants formed large colonies at a very low frequency and induced tumors after a prolonged incubation period. These results indicate that there is a good correlation between the capacity of cells to grow without anchorage and the capacity to form tumors in nude mice and suggest that the revertant phenotype is stable in the presence of T antigen when the number of chromosomes is greatly increased as compared with that of the transformed parent cells.

Animals↗
PubMed1982

Role of the nongravid part of the uterus in the regulation of corpus luteum function in pregnant rats.

The effect of the nongravid part of the uterus on corpus luteum (CL) activity was studied in rats bearing a single conceptus during midpregnancy. On day 7 (day 1 = insemination), the number of conceptuses was reduced to one by aspirating all but one conceptus (the aspiration group), by removing all of of the uterus except that containing a single conceptus (the hysterectomy group), or by aspirating conceptuses, as in the aspiration group, plus ligating the uterus, as in the hysterectomy group, but without removing the uterus (the sham hysterectomy group). Rats with a full complement of conceptuses (the intact control group) served as additional controls. Blood samples were obtained on days, 10, 12, and 15, to determine the effects of these procedures on the increase in serum progesterone that normally occurs between days 12 and 15 and to observe any related changes in serum LH between days 10 and 15. On day 15, the mean serum prgesterone concentrations and weights of the CL in the aspiration and sham hysterectomy groups were significantly lower than those in the intact control group. In the hysterectomy group, however, serum progesterone was even higher than in the intact control group, although the CL were significantly smaller than in the intact control group and were not different from those in the aspiration or sham hysterectomy groups. Serum LH on day 10 was significantly lower in the hysterectomy group than in any of the other groups; the latter were not significantly different from each other. By day 15, serum LH in the intact group had fallen to less than 50% of the value on day 10, while in the aspiration group, it remained as high as on day 10. In the hysterectomy group, there was no significant difference in serum LH concentrations between days 10 and 15. These results suggest that the nongravid part of the uterus inhibits progesterone secretion, and that in its absence, even a single conceptus can increase progesterone secretion after day 12 as much as can a full complement of conceptuses, but without also increasing the size of the CL. The uterus may exert this effect either through the pituitary or in cooperation with a pituitary factor, possibly LH.

Animals↗