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Biomedical subjects

K Tsuji

Publications and source records attributed to K Tsuji.

At least 721 records · Page 40Linked to original sources
PubMed1983

[Case of Borrmann III stomach cancer effectively treated by UFT therapy (co-administration of uracil and futraful)].

Through X-ray and endoscopic examination of stomach, a 77 year-old man, who complained of epigastralgia, he was diagnosed to have Borrmann III type gastric carcinoma on the antrum. The gastric biopsy specimen obtained from the tumor revealed to be well differentiated adenocarcinoma. Since the patient refused receiving surgical treatment, a combined administration of futraful and uracil (UFT therapy) was performed. 4 weeks after receiving UFT therapy, the patient became less aware of subjective symptom and the gastrofiberscopic picture showed smaller mass lesion compared to that of prior to the treatment. 8 weeks later, the tumor was remarkable reducing its size. When compared 14 cases of gastric carcinoma receiving UFT therapy with 26 cases receiving Futraful therapy (FT therapy), the UFT group responded more effectively than the FT group. In the UFT therapy, complete (CR) and partial response (PR) were obtained in 4 of 13 cases of gastric carcinoma with an effective rate of 30.8% according to the response criteria proposed by the Koyama-Saitoh group and with a Karnofsky scale of IA or better in 6 (42.8%) of 14 cases. On the other hand, in the FT therapy CR and PR were obtained in 5 of 26 cases with that of 19.2%, while a Karnofsky scale of IA or better was achieved in 6 (23.1%). As for 3 cases of PR in the UFT therapy the microscopic view of the biopsy specimen from gastric carcinoma showed well differentiated adenocarcinoma, which responded to the UFT therapy remarkably 4-5 weeks after receiving UFT therapy.

Adenocarcinoma↗
PubMed1983

[Evaluation of myocardial ischemia in acute myocardial infarct by thallium scintigraphy and radioisotope angiography].

It is very important to evaluate the size of myocardial infarction and reversibility of ischemic myocardium in order to determine the severity and prognosis of patients with acute myocardial infarction. We performed thallium-201 redistribution myocardial scintigraphy and first pass radionuclide angiography in 12 patients with acute myocardial infarction. In eight cases, left ventricular wall motion was improved after nitroglycerin infusion (improved group), but in four cases it was unchanged (non-improved group). Six of the improved group showed a positive redistribution image, while in the non-improved group, no patient showed such an image. Ejection fraction increased after nitroglycerin infusion in the improved group, but unchanged in the non-improved group. There was no significant difference in hemodynamic parameters between the two groups at the time of admission, and after treatment hemodynamic parameters changed in the same way in both groups. In coronary angiography, three collateral channels were observed in the improved group, but none in the non-improved group. The severity of coronary artery stenosis in the two groups was almost identical. In eight patients, their regional ventricular wall motion improved after nitroglycerin administration, but there were four patients whose regional ventricular wall motion was unchanged. In both groups, hemodynamic and coronary angiographic findings were not different. But there were many positive redistribution images and collateral channels in the improved group. This result shows that reversible ischemia is indispensable for the improvement of regional wall motion. There was a case which showed a positive redistribution image on acute phase Tl-201 scintigraphy and a transient defect on the chronic phase exercise Tl-201 scintigraphy. But after the improvement of ischemia by aorto-coronary bypass operation, the defect on Tl-201 scintigraphy decreased and the wall motion improved. Neither redistribution on acute phase scintigraphy nor a transient defect on chronic phase exercise scintigraphy was observed in the non-improved group. From these data we conclude that the improvement of regional wall motion depends on reversible ischemia.

Adult↗
PubMed1983

Immunogenetical study in patients with chronic glomerulonephritis.

HLA-A, B and DR typing was performed on a total of 236 patients with chronic glomerulonephritis (CGN) which were diagnosed by renal biopsies evaluated by light microscopy, direct immunofluorescent staining and whenever indicated electron microscopy. The interrelationship between the HLA system and the histopathologic classification of CGN was examined. There were 20 patients with benign recurrent hematuria (BRH), 82 with IgA nephropathy (IgA-N), 24 with proliferative glomerulonephritis (PGN), 47 with minimal change nephrotic syndrome (MCNS), 4 with membranous nephropathy (MN), 43 with membranoproliferative glomerulonephritis (MPGN) and 16 with focal glomerulosclerosis (FGS). The following results were obtained: 1) Antigens from different loci were associated with different subgroups of CGN. There were three types of associations; a) HLA-A locus associated as found in PGN, b) HLA-B locus associated as found in BRH and c) HLA-DR locus associated as found in MCNS. IgA-N, MPGN and FGS seemed to be included in this group. 2) The association of HLA-A locus antigens with MCNS could be subdivided by age o onset suggesting that in MCNS HLA-A antigens are linked to disease expression. 3) A heterogeneity in IgA-N is suggested by its association with different HLA antigens; a) a HLA-B37 associated group, b) a HLA-DR4 or DYT associated group and c) a HLA-DEn (Dw 6.1) or B12 associated group. These data suggest differences in the mechanisms of HLA and disease association in each histopathologic subtype of CGN.

Adolescent↗
PubMed1983

Familial leukemia. HLA system and leukemia predisposition in a family.

Four cases of acute lymphocytic leukemia occurred in a family comprising 30 members. Genetic and cytogenetic studies showed a possible linkage between an HLA haplotype and the leukemia predisposition that was suggested by site-directed chromosome rearrangements in cultured skin fibroblasts. The possession of genetic markers, other than HLA types, could not be linked to the occurrence of leukemia in the family. These findings suggest that the major histocompatibility complex or gene(s) linked to it may have played a part in the pathogenesis of the leukemic process in this family.

Blood Proteins↗
PubMed1983

Studies on experimentally induced hydrosalpinges in rabbits--experimental approach for tubo-microsurgery.

Hydrosalpinx proved macroscopically and microscopically which was quite similar to that observed in the damage human fallopian tube could be induced by ligation of the rabbit fallopian tube. Where ligatures have been placed on two places of the fallopian tube, hydrosalpinx can be induced in 100 percent of cases if ligation is done securely. About 1-2 weeks after ligation, no change of ciliated cells was observed in the mucosal fold in SEM findings, nor was there much change in the external shape of non-ciliated cells even though hydrosalpinx was induced. With the lapse of time after development of hydrosalpinx, however, both of these cells on the surface of the mucosal fold gradually changed to loose their normal shapes. After 15 weeks, ciliated cells all but disappeared to be replaced by large, filled, irregular non-ciliated cells. Accordingly, hydrosalpinx in the early stage can be cured fully by tubal salpingostomy using microsurgery. In the case of hydrosalpinx many hours after ligation, however, end-to-end anastomosis of the normal regions should be performed since no recovery can be expected.

Animals↗
PubMed1982

Micro-bore high-performance liquid chromatography for the analysis of pharmaceutical compounds.

A micro-bore high-performance liquid chromatographic (HPLC) system has been constructed using commercially available instruments and pre-packed micro-bore columns. The flow-rates to obtain the highest efficiency for a reversed-phase column and for a silica column are ca. 20 microliters/min and 5 microliters/min, respectively. The micro-bore HPLC system is sixteen times more sensitive than a conventional HPLC system for detection of a compound. With little or no modification in the composition of mobile phases used in conventional HPLC, micro-bore HPLC attains high column efficiency and peak resolution for the analysis of antibiotics, steroids, ibuprofen and sulfonylurea. Micro-bore HPLC has been demonstrated to be capable of performing high speed analysis with a relative standard deviation of ca. 1%.

Anti-Bacterial Agents↗
PubMed1982

Determination of allantoin and chlorohydroxyaluminium allantoinate in cosmetic and pharmaceutical products by high-performance liquid chromatography.

A high-performance liquid chromatographic method is described for convenient and direct determination of allantoin derivatives, by which as little as 0.1 micrograms of the compounds can be determined without any conventional sample preparation required to eliminate interferences. Chromatographic separation on a resin-based strong cation exchanger (H+) using water as eluent is combined with sensitive and selective post-column reaction of the allantoin derivatives. After dissolution of the sample in hot water, the determinations take 12 min per sample. The relative standard deviation is less than 1.8% and quantitative recoveries are obtained. Several commercial cosmetic and pharmaceutical products were analysed successfully. The method can be applied to test the stability of the compounds in formulations.

Allantoin↗
PubMed1982

Improved high-pressure liquid chromatographic method for the analysis of erythromycin in solid dosage forms.

A stability-indicating high-pressure liquid chromatographic (HPLC) method for the assay of erythromycin in enteric film-coated tablets was developed. The method used a reversed-phase column at 70 degrees with a mobile phase of acetonitrile-methanol-0.2 M ammonium acetate-water (45:10:10:35) at pH 7.0. The column were evaluated for the analysis of erythromycin. The HPLC method was also applicable for the analysis of salts and esters of erythromycin. The linearity and precision of the HPLC assay method for erythromycin in the solid dosage form were examined by spiking erythromycin into a tablet placebo a 60-120% of the label. The recovery of erythromycin was 99.9% with a relative standard deviation of less than 1%. The correction factors to express the results of HPLC in terms of antimicrobial bioequivalency against Staphylococcus aureus TCC 6538P for erythromycins A, B, and C were determined to be 1.0, 0.92, and 0.48, respectively. Eight lots of tablets were assayed by the HPLC method, and the results, expressed in terms of erythromycin bioequivalency, showed no statistically significant difference from those of the microbiological assay method.

Bacteria↗
PubMed1982

HLA-D clusters associated with DR4 in the Japanese population.

A study of HLA-D clusters associated with DR4 was performed in the Japanese population. These clusters consist of DYT, DKT2, DB3, and Dw4. Forty-two Japanese typed as DR4 were investigated, and it was found that 17 (40.5%) were DYT, 7 (16.7%) DKT2, 7 (16.7%) DB3, and 4 (9.5%) Dw4.

HLA-DR4 Antigen↗
PubMed1982

HLA-DR antigens and the rubella-specific immune response in man.

Several genetic markers, HLA-A, B and DR antigens, Gm and Km types, and ABO blood types, were studied on 78 rubella seronegative schoolgirls immunized with "TO336" rubella vaccine. A marked association was found between an HLA haplotype, HLA-Aw24-Bw52-DRHO, and the low antibody responsiveness to rubella virus. The association with the DR antigen was thought to be primary to those with the HLA-A or B antigens, suggesting that the gene(s) controlling the low responsiveness to rubella might be located near the HLA-DR locus in the human 6th chromosome. There was no statistically significant association between Gm, Km or ABO blood types and the rubella specific immune responsiveness as far as the primary in vivo antibody response was concerned.

Antibodies, Viral↗
PubMed1982

Histocompatibility antigens in Parkinson's disease.

The possible association of 7 HLA specificities in the HLA-A locus and 16 specificities in the HLA-B locus with susceptibility to Parkinsonian syndrome was investigated in a total of 36 patients with paralysis agitans (PA), as well as in 11 patients with other Parkinsonian syndromes, and 176 controls in Japan. There was no clear association between HLA-A or -B locus antigens and PA or other Parkinsonian syndromes. Patients with PA were subdivided according to sex, age of onset, clinical manifestations, and response to L-Dopa therapy. There was, however, no apparent association between HLA-A or -B locus antigens and any of the variables investigated. Our data do not provide any evidence for genetic susceptibility in the pathogenesis of PA.

Adult↗