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Biomedical subjects

K Tsuchiya

Publications and source records attributed to K Tsuchiya.

At least 685 records · Page 38Linked to original sources
PubMed1976

3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. II. Comparative in vivo antibacterial activities of SCE-100 and cephalexin (CEX).

The protective activity of 3-deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100) against experimental intraperitoneal infections in mice caused by several strains of Gram-positive and Gram-negative organisms, including penicillin resistant strains, was compared with that of cephalexin (CEX). Comparable protective effects by oral administration of SCE-100 and CEX were observed in mice infected with Gram-positive organisms, while in mice infected with Gram-negative organisms SCE-100 was less active than CEX. SCE-100 showed a protective effect in infections of mice with either penicillin G-resistant Staphylococcus aureus or ampicillin-resistant Escherichia coli. The oral ED50 of SCE-100 was similar to or slightly larger than the subcutaneous value.

Administration, Oral↗
PubMed1976

3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. III. Comparative studies on absorption, distribution and excretion of SCE-100 and cephalexin (CEX) in laboratory animals.

3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetoamido) cephalosporanic acid (SCE-100) was compared to cephalexin with respect to absorption, tissue distribution, and urinary and biliary excretion in mice, rats, rabbits and dogs. The absorption of SCE-100 after oral administration is generally slower than that of cephalexin, but its disappearance from blood and tissues is delayed. The concentration of SCE-100 in the liver is distinctly higher than that of cephalexin. These properties of SCE-100 are most clearly manifested in rats. There is no significant difference in urinary excretion of the two cephalosporins in rabbits and dogs, while in rabbits, biliary excretion of SCE-100 is more intensive than that of cephalexin.

Administration, Oral↗
PubMed1975

Geographical distribution of twelve transferrin alleles in black rats of Asia and Oceania.

About 450 black rats (Rattus rattus) were collected from 25 localities in Asia and Oceania. Their serum transferrins were analyzed by a newly developed thin layer acrylamide gel electrophoresis accompanied with acrinol pretreatment, exhibiting 12 transferrin bands. Generally, Asian type rats (2N=42) had fast-moving transferrins (R-series), Ceylon type (2N=40) moderately moving ones and Oceanian type (2N=38) slowly moving ones (C-series). Exceptionally, in northern India and Pakistan all Asian-type rats had C-series Tf. The possibility that divergence of R-series Tf and C-series Tf had proceeded the karyotypic differentiation from 42 to 38 is proposed. In combination with the previous molecular data, the time of the divergence is roughly estimated between the order of a million years and ten thousand years.

Alleles↗
PubMed1975

An epidemiological study of occupational bladder tumours in the dye industry of Japan.

This report studies 100 cases of occupational bladder cancer which were reported between 1949 and 1970 by large companies producing dye. It is estimated that in fact a great many more than 100 cases may have developed during the 56 years from 1914 to 1970, as this period corresponds with the beginning of dye production to the termination of benzidine and beta-naphthylamine manufacture in Japan. New cases of occupational bladder tumour should diminish significantly in the future in Japan on account of the prohibition of the production of beta-naphthylamine and benzidine. However, it is important to follow-up continuously workers who have been exposed to these amines. In Japan no cases of occupational bladder tumours from the rubber industry have been reported. It is emphasized that prospective epidemiological studies are required not only in the rubber industry but also in other industries where amines may constitute an occupational hazard.

2-Naphthylamine↗
PubMed1975

[The effects of flavoxate hydrochloride on the gastrointestinal motility (author's transl)].

The experiments were performed to study the effects of Flavoxate hydrochloride on the gastrointestinal motility and its underlying mechanism. Gastrointestinal motility was inhibited at first and then accelerated markedly after the intravenous injection of Flavoxate hydrochloride (10 mg/kg) in the experiments of anesthetized dogs. For analyzing the underlying mechanism of this response the following experiments were executed. 1) The pendular movements of isolated ileum of rabbits were accelerated with administration of low concentration of Flavoxate hydrochloride less than 10(5) g/ml, while these were reduced with administration of high concentration more than 10(4) g/ml. Because the tetrodotoxin (2.5 times 10(7) g/ml) has no essential effect on these responses, it could be postulated that Flavoxate hydrochloride has direct effect on intestinal smooth muscle itself. 2) Flavoxate hydrochloride (10 mg/kg) induced the differentiated regional response of the sympathetic outflow, that is, the parallel decrease of cutaneous and cardiac sympathetic activities, and the converse increase of splanchnic activity. Therefore, Flavoxate hydrochloride is thought to have an effect on the integrating mechanism of the sympathetic nervous system. This view was also supported by the experiments with neuromuscular preparation of lobster (Panulirus japonicus). It is concluded from these results, that the change of gastrointestinal motility induced by intravenous injection of Flavoxate hydrochloride (10 mg/kg) is influenced both by its effect on the gastrointestinal smooth muscle itself and by its effect via the autonomic nervous system.

Animals↗
PubMed1975

[Effects of various agents and transmural electric stimulation on the motility of isolated bile duct of the dolphin (Stenella caeruleoalbus) (author's transl)].

The isolated bile duct preparations, which contain the duodenal circular muscle, and the proper bile duct muscle preparations in the dolphin (Stenella caeruleoalbus) were used and their longitudinal motilities were recorded by means of strain gauge transducer. 1. Raising the intraluminal pressure produced the augmentation of the motility of the bile duct preparation. 2. Acetylcholine and carbamylcholine caused the increase of the motility of the bile duct preparations. After atropinization the excitatory response was completely abolished. 3. Adrenaline caused the inhibitory response more predominantly than the excitatory one in the bile duct preparations, while in the proper bile duct muscle preparations it induced the excitatory response more predominantly than the inhibitory one. Phenylephrine produced mainly the excitatory effect in both preparations, while isoprenaline did chiefly the inhibitory one. These experimental results suggest that activation of alpha- and beta-adrenergic receptors in the bile duct muscle causes the excitatory and inhibitory responses, respectively. 4. Transmural electric stimulation induced both excitatory and inhibitory responses in the bile duct preparation. The former response was abolished after atropinization, while the latter one was not. It may be, therefore, suggested that the excitatory response was induced by stimulation of cholinergic neurons, while the inhibitory one was produced by that of the adrenergic fibers and non-adrenergic inhibitory neurons.

Acetylcholine↗
PubMed1975

Range of xenogeneic donors whose hematopoietic cells can form colonies on macrophage layer of mice.

The colony-forming ability of hematopoietic cells derived from 18 species of rodents was examined on the mouse macrophage layer which formed on a cellulose acetate membrane inserted into the peritoneal cavity of mice. Bone marrow cells of 12 xenogeneic species made a considerable number of colonies on the mouse macrophage layer. However, there was no parallelism between the colony-forming ability of the cells and donor's taxonomic relationship to the mouse.

Animals↗