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Biomedical subjects

K Tsuchiya

Publications and source records attributed to K Tsuchiya.

At least 667 records · Page 37Linked to original sources
PubMed1978

[Dose-response relationships at different exposure levels. Re-examination in establishing no-effect levels (author's transl)].

In this study dose-response and dose-effect relationships were examined with reference to no-effect levels using observed data from three groups of lead workers who had been exposed to three different concentrations of lead. Blood lead concentration (PbB) was used for "dose" and ALA concentration in urine (ALAU) and rate for 5 mg/l or greater of ALAU were used as "effect" and "response" respectively. Dose-effect and dose-response relationships between PbB and ALAU of these three different exposure populations indicated three different curves although theoretically they should all have indicated a similar curve. This means that "effect" or "response" for the highest exposure group was higher than that for the lowest exposure group on the same "dose" level. This difference is statistically explained for the most part by variations in the determinations of "dose" (PbB) as well as "effect" or "response" (ALAU). In view of the above results, it would seem that re-examination is required in establishing criteria of no-effect levels for dose-response relationships of various environmental chemicals.

Aminolevulinic Acid↗
PubMed1977

Various effects of arsenic in Japan depending on type of exposure.

Since 1955, a number of outbreaks of arsenic poisoning have occurred throughout Japan among industrial workers and the general population. The sources and types of exposure differ according to the incident, and the victims vary in sex and age. These incidents include arsenic poisoning in milk, soy sauce, and well water, pollution originating from the Toroku Mine on the island of Kyushu, the Matsuo Mine in Shimane Prefecture and Saganoseki Smelter on Kyushu. The type, routes, and dose of exposure as well as major symptoms are given. The clinical signs and symptoms are discussed in relation to the various types of exposure which occurred in these incidents. Dose-response relationships will be considered where data are available.

Adult↗
PubMed1977

[Various factors influencing toxicity and metabolism of metals--metal-metal interactions and host factors (author's transl)].

This paper is a brief overview on metal-metal interactions and various other factors involved in the toxicity and metabolism of metals, including host factors, nutrition, habits, etc. Humans and other organisms are exposed to various metals in many ways, and even in an occupation in which workers are exposed to a metal such as lead, they are at the same time also exposed to other metals, although concentrations of these latter metals are usually not very high. This can result in effects different from those produced by a single metal by itself. Furthermore, individual differences which are caused by genetic, nutritional, hormonal, habitual, and many other factors may alter the toxic or metabolic effects of a single metal. Information on this subject is rather limited. This paper is a brief introduction to the importance of future studies on the topic, and the author hopes that it will stimulate more studies by those who are interested in the field of metal toxicology.

Animals↗
PubMed1976

3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. I. Comparative in vitro antibacterial activities of SCE-100 and cephalexin (CEX).

3-Deacetoxy-7(alpha-amino)-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100) has a potent antibacterial activity against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration of SCE-100 is 0.2 approximately 12.5 mug/ml against Gram-positive bacteria including penicillin G-resistant Staphylococcus aureus and 6.25 approximately 100 mug/ml against Gram-negative bacteria. SCE-100 inhibits clinically isolated strains of penicillin G-resistant S. aureus and ampicillin-resistant Escherichia coli, as well as the corresponding sensitive strains. The activity of SCE-100 is enhanced by decreasing the inoculum size and is only slightly influenced by medium pH, difference of medium composition and the addition of horse serum. SCE-100 has bactericidal activity against S. aureus and E. coli. There is a stepwise development of in vitro bacterial resistance to SCE-100 by serial transfer of organisms into a liquid medium containing SCE-100. Cross resistance was observed between SCE-100 and other tested cephalosporins.

Bacteria↗