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Biomedical subjects

K Teramo

Publications and source records attributed to K Teramo.

At least 127 records · Page 7Linked to original sources
PubMed1979

Effect of maternal position on fetal heart rate during extradural analgesia.

Using continuous cardiotocography, the effect of maternal position on fetal heart rate (FHR) was studied during extradural analgesia (EA) with either 50 or 100 mg of etidocaine without adrenaline for labour and vaginal delivery. Of 70 healthy parturients, 39 were supine and 40 were in the lateral position. FHR was normal in all patients during the control period before EA, and remained normal during EA in 53. Transient abnormal patterns occurred in 26 patients, 22 (56%) in the supine group and four (10%) in the lateral group, a significant difference (P less than 0.001). The decrease in arterial pressure (AP) did not differ between the groups, but the frequency of abnormal FHR associated with a small or moderate decrease in AP (30% or less) was greater in the supine (51%) than in the lateral group (3%).

Adolescent↗
PubMed1979

Changes in placental intervillous blood flow measured by the 133xenon method during lumbar epidural block for elective caesarean section.

The effect of lumbar epidural block on placental intervillous blood flow (IBF) was estimated with the i.v. 133Xe method in 24 cases and in 14 controls. All parturients had uneventful pregnancies and were scheduled for elective caesarean section. Lumbar epidural block caused a significant decrease in maternal mean arterial pressure (MAP), when no preloading infusion with a plasma expander was given. In contrast, the MAP remained unchanged during lumbar epidural block when the parturients received a preloading infusion (Haemaccel, 100 ml/10 kg body weight within 10 min immediately before lumbar epidural block). The IBF decreased to some extent in the non-preloaded group, but increased temporarily in the preloaded group 15 min after the administration of lumbar epidural block. The mean changes of IBF in the non-preloaded and the preloaded groups differed statistically significantly from each other during lumbar epidural block. The IBF of the preloaded group did not differ significantly from the IBF of the control group receiving no lumbar epidural block.

Adult↗
PubMed1979

Fetal heart rate during a maternal grand mal epileptic seizure.

Although maternal ingestion of antiepileptic drugs is strongly suspected of causing congenital defects, particularly oral clefts, the effect of epilepsy itself or a combined effect of drug intake and epilepsy have not been excluded as etiological factors. Very little is known about fetal oxygenation during a maternal grand mal epileptic seizure. We describe two cases in which fetal heart rate was recorded during a maternal epileptic seizure during labor. The first fetus became clearly asphyctic as judged from the fetal heart rate recording: immediately after the epileptic seizure there was a 13-minute continuous bradycardia wave with decreased short-term variability. After the bradycardia a phase of tachycardia with decreased short-term and long-term variability occurred. In the other fetus there was only a short period of bradycardia, which was followed by a phase of tachycardia and decreased short-term and long-term variability. Both fetuses were vigorous at birth 43 and 87 minutes, respectively, after the epileptic seizures of their mothers. We conclude that a maternal grand mal epileptic seizure can be ominous to the fetus. It is therefore important that epileptic seizures are controlled by optimal medication throughout pregnancy.

Adult↗
PubMed1979

Amniotic fluid phospholipid profile as a predictor of fetal maturity in diabetic pregnancies.

The phospholipids in amniotic fluid from diabetic pregnancies were compared with those in normal pregnancies. There was little difference in the lecithin/sphingomyelin (L/S) ratios on the basis of the gestational ages. However, in diabetic pregnancies, phosphatidylglycerol (PG) was absent or low, and phosphatidylinositol (PI) remained high even if the L/S ratio was greater than 2. The phosphatidylglycerol/phosphatidylinositol (PG/PI) ratio was expressed as a function of the L/S ratio. The PG/PI ratio was significantly lower in maternal diabetes. Respiratory distress syndrome (RDS) coincided with an L/S ratio of between 2.0 and 3.0 only when PG was absent. Infants of insulin-dependent diabetic mothers with a particularly low PG/PI ratio (less than 50% of the median) had higher relative birth weights and more often had hypoglycemia than those infants born to mothers with a high PG/PI ratio (greater than 200% of the median). The phospholipids of amniotic fluid correlate with fetal functional maturity and may reflect deviations of hormonal balance required for normal perinatal development.

Amniotic Fluid↗
PubMed1978

Spontaneous rupture of fetal membranes after amniocentesis.

Three hundred eighty amniocenteses in 200 parturients were reviewed for success or failure in obtaining amniotic fluid, number of attempts for each amniocentesis, premature rupture of the fetal membranes, presence of blood, and the perinatal outcome. The highest success rate was in cases in which amniocentesis was performed between the symphysis and the presenting part of the fetus. The total incidence of spontaneous rupture of fetal membranes within 5 days after the last amniocentesis was 13.5%. When the amniocentesis was performed behind the fetal neck, the membranes ruptured significantly more frequently (P less than 0.05) than after amniocentesis at other sites. It is concluded that the area behind the fetal neck should be avoided if possible at amniocentesis. There were no severe be avoided if possible at amniocentesis. There were no severe fetal or neonatal complications from amniocentesis in these patients.

Amniocentesis↗
PubMed1976

Gestational differences in lidocaine toxicity in the fetal lamb.

Effects of lidocaine on arterial pressure, heart rate and electrocortical activity were studied in nine fetal lambs at 0.77 to 0.92 gestation (116 to 138 days of gestation; term in sheep is 150 days). Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection. Epileptiform activity was observed in all fetuses both after continuous infusion and after bolus injection of lidocaine. Fetal arterial concentrations of lidocaine at the time of the first epileptiform discharge during continuous infusion ranged from 6.9 to 40.0 mug/ml, and correlated negatively with gestational age (Y equals -1.727 x +242.7; r equals -0.94). The increases in fetal mean arterial pressure during epileptiform bursts correlated directly with the gestational age (Y equals 1.27 x -150.0; r equals 0.91). The convulsive doses of lidocaine injected as a bolus ranged from 8.0 to 34.1 mg/kg, and correlated negatively with gestational age (Y equals -0.991 x +144.9; r equals -0.88). The increased sensitivity to lidocaine of the fetal central nervous system with advancing gestation probably reflects differences in fetal brain development. The increase in cardiovascular responses to epileptiform activity with advancing gestation could be related to differences either in the strength of epileptiform discharges or in permeability of the blood-brain barrier to lidocaine, or to immaturity of the autonomic nervous supply to the cardiovascular system in young fetuses.

Animals↗