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Biomedical subjects

K Teramo

Publications and source records attributed to K Teramo.

At least 109 records · Page 6Linked to original sources
PubMed1982

The monitoring of labor by telemetry.

Telemetry and conventional cardiotocography were compared by monitoring the labor of 60 patients with an uneventful pregnancy and delivery in the 38th-42nd week of pregnancy. 31 patients were monitored by telemetry and 29 by cardiotocography. The patients were matched for age (+/- 5 years), duration of pregnancy (+/- 7 days) and parity (I or II). The husband attended labor and delivery in 42% of the cases in the telemetry group and in 59% of the cases in the control group. Induction of labor by amniotomy was performed in 32% of the cases in the telemetry group and in 24% of the cases in the cardiotocography group. The patients monitored subjective pain every half hour during the opening phase. The telemetric patients were encouraged to sit or walk during the first stage. No maternal or fetal complications occurred. All infants were born in good condition with APGAR scores greater than or equal to 7 recorded at one and five minutes. There were 4 operative deliveries in the telemetry group and 5 in the control group. Indications for these were maternal or uterine exhaustion with the exception of two control patients where fetal asphyxia was suspected. The duration of the first stage of labor did not differ significantly between the telemetry and the cardiotocography groups. The telemetric patients received less analgesics than the controls but this difference was not significant. In spite of less analgesia in the telemetry group, the secondparas of the telemetry group experienced significantly less (p less than 0.01) labor pain than the controls. In addition, the secondparas of the telemetry group considered the present labor less painful than the previous one significantly more often than the controls. Among the primiparous patients there was no difference in the amount of pain experienced by the patients.

Adult↗
PubMed1982

The influence of rapid changes in blood glucose on glycosylated hemoglobin measured by microcolumn and macrocolumn chromatography.

The effect of a rapid rise in blood glucose on glycosylated hemoglobin (HbA1) was measured by two different cation exchange chromatographic methods. Blood samples were taken after fasting and one hour after breakfast from 32 insulin treated diabetics for the measurement of 1) HbA1 with a microcolumn procedure with and without prior incubation of the samples in saline overnight and 2) HbA1 and HbA1c with the macrocolumn chromatographic method of Trivelli with and without prior dialysis of the hemolysates. Mean (+/- SEM) blood glucose concentration rose significantly one hour after breakfast from 9.8 +/- 0.8 mmol/l to 14.9 +/- 0.8 mmol/l (p less than 0.001). The corresponding HbA1-concentrations measured by microcolumn chromatography without incubation of the samples were 15.2 +/- 0.5% (fasting) of total hemoglobin and 15.8 +/- 0.6% (postprandial) (p less than 0.001) and after incubation 13.3 +/- 0.4% and 13.2 +/- 0.4%, respectively (NS). The HbA1-concentrations measured by the method of Trivelli without dialysis were 14.7 +/- 0.5% (fasting) and 14.9 +/- 0.5% (postprandial) (p less than 0.01) and after dialysis of the hemolysates 14.3 +/- 0.5% and 14.3 +/- 0.5%, respectively (NS). The HbA1c-concentrations measured by the macrocolumn method without dialysis were 11.1 +/- 0.4% (fasting) and 11.2 +/- 0.4% (postprandial) (p less than 0.05) and after dialysis 10.9 +/- 0.4% and 10.8 +/- 0.4%, respectively (NS). Acute hyperglycemia may cause an increase in HbA1-values determined by microcolumn chromatography, the magnitude of which can exceed 20% in an individual case. The acute effect can be abolished by incubation of the samples in saline overnight.

Adult↗
PubMed1981

Maternal and foetal drug levels after epicutaneous application of a local anaesthetic formulation containing ketocaine for possible use as pain relief in labour.

A local anaesthetic formulation (A 2358) containing ketocaine, a local anaesthetic drug, was applied epicutaneously to the low back. Two compresses soaked with A 2358 were applied for 1 hour in 26 normal labours for relieving referred pain from the low back. The maternal blood ketocaine levels remained low, compared to higher systemic levels reported in other studies. Maternal heart rate and blood pressure were stable during the application time. The mean umbilical vein/maternal vein and umbilical artery/maternal vein concentration ratios were 0.20 +/- 0.10 and 0.21 +/- 0.09. In addition, the foetal heart rate findings and the conditions of the neonates were satisfactory, thus suggesting the foetal safety of this analgesic method.

Adolescent↗
PubMed1981

Measurement of the lecithin/sphingomyelin ratio and phosphatidylglycerol in aminotic fluid: an accurate method for the assessment of fetal lung maturity.

A total of 506 amniotic fluid samples from 337 pregnancies was analysed for lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol. Two-dimensional chromatography on either laboratory-made or commercial thin-layer silica gel plates was required for proper resolution of the phospholipids. The predictive accuracy of the L/S ratio and the phosphatidylglycerol analysis was assessed in 225 patients, 187 of whom had an L/S ratio of 2 or more. In addition to predicting respiratory distress syndrome of the newborn, the phospholipid results predicted the risk of transient tachypnoea, symptomatic pneumothorax and the persistence of fetal circulation. The phosphatidylglycerol results improved the predictive value of both the mature L/S ratio (2 or more) and the non-mature L/S ratio (below 2).

Amniotic Fluid↗
PubMed1981

Haemoglobin AIc predicts the perinatal outcome in insulin-dependent diabetic pregnancies.

Haemoglobin AIc (Hb AIc) was measured in 112 insulin-dependent diabetic pregnancies on an average 4.7 times. Hb AIc was high in early pregnancy in all three patients with severe fetal malformations. There were six pregnancies with a perinatal death. The maximum Hb AIc values were significantly higher in the second trimester (p less than 0.001) in these pregnancies than in the other diabetic pregnancies. When neonatal hypoglycaemia was present, the mean maternal Hb AIc was significantly higher in the second (p less than 0.005) and third (p less than 0.02) trimesters of pregnancy than in the group without neonatal hypoglycaemia. In the group with neonatal hyperbilirubinaemia the mean maternal Hb AIc was significantly higher in the third trimester (p less than 0.02) than in the group with no neonatal hyperbilirubinaemia. The results suggest that poor metabolic control of maternal diabetes during the second trimester is associated with a clearly increased risk of perinatal death and during the second and third trimesters with metabolic derangements in the neonatal period. The results also indicate that Hb AIc could be used to detect the pregnant diabetics at special risk.

Adolescent↗
PubMed1981

Treatment of maternal hyperthyroidism with antithyroid agents and changes in thyrotrophin and thyroxine in the newborn.

Eleven pregnant women with concomitant hyperthyroidism were treated with antithyroid drugs. At monthly intervals serum thyroxine (T4) and triiodothyronine (T3) were measured with radioimmunoassay, the Sephadex uptake of radioactive triiodothyronine (T3U) determined the free T4 and T3 indices calculated (FT4I, FT3I). TSH-binding inhibiting immunoglobulins (TBII) were determined by the radiomembrane assay. Serum TSH and T4 were measured at delivery from cord blood and/or from the newborn infants some days after birth. Serum TSH was significantly elevated in one infant. There was an inadequate post-partal rise in serum T4 concentration in this child and in another who showed only a marginal elevation of TSH. The mothers of these infants were given carbimazole in doses of 30 and 25 mg/day, respectively, at the time of delivery. No significant changes were seen in other infants, the daily doses being 20 mg of carbimazole or less. There was no clinical indication of hypo- or hyperthyroidism in any of the newborn. The TBII were positive in most patients and there was a trend of normalization during treatment. No relationship between the dose of antithyroid drug and the level of TBII could be seen. During treatment the dose was adjusted according to the FT3I values. This seems to be an adequate laboratory test for this purpose.

Adult↗
PubMed1980

Glial origin of rapidly adhering amniotic fluid cells.

Rapidly adhering cells (RA cells) from the amniotic fluid of a pregnancy with fetal anencephaly were investigated by immunofluorescence assay with an antiserum against glial cells. After 24 hours' cultivation a high proportion of the cells showed positive glial-specific fluorescence, whereas no staining was seen in cells from samples of normal amniotic fluid. At the 24th week the mother was delivered of a stillborn infant with anencephaly. Immunofluorescence staining of RA cells with glial-specific antiserum may be used for the differential diagnosis of fetal abnormalities associated with a high alpha-fetoprotein concentration in amniotic fluid.

Adult↗
PubMed1980

Maternal glucocorticoid in unplanned premature labor. Controlled study on the effects of betamethasone phosphate on the phospholipids of the gastric aspirate and on the adrenal cortical function of the newborn infant.

The effects of betamethasone on surfactant composition and neonatal adrenal function were compared with placebo in a double-blind study, which included 74 patients at risk for premature delivery. The overall incidence of respiratory distress syndrome was low, and no differnce was observed between the betamethasone and placebo groups. The phospholipid pattern (lecithin/sphingomyellin ratio, acetone precipitated lecithin, phosphatidylinositol/sphingomyelin ratio, and phosphatidylglycerol/sphingomyelin ratio) from gastric aspirates of newborn infants was similar in the betamethasone and placebo groups, suggesting a similarity in lung surfactant. The responsiveness of the adrenal cortex of the newborn infants, evaluated by a 2-hr adrenocorticotropic hormone test at the age of 24 hr, did not differ between infants whose mothers had received either betamethasone or placebo. The low incidence of respiratory distress syndrome in the betamethasone and placebo groups was ascribed in part to a high incidence of prolonged rupture of fetal membranes. Our results do not exclude the possibility that antenatal maternal administration of betamethasone could prevent respiratory distress syndrome in other defined high-risk infants.

Adrenal Cortex↗
PubMed1980

Phospholipid studies of the amniotic fluid in diabetic pregnancy.

The lecithin/sphingomyelin ration (L/S) of the amniotic fluid is a reliable indicator of fetal lung maturity in most disorders complicating pregnancy. False positive results of L/S occur especially in diabetic pregnancies. Phosphatidylglycerol (PG) improves the ability of the surface active lecithin to prevent lung atelectasis. Respiratory distress syndrome of the newborn infant does not seem to occur when PG is present. By determining PG of the amniotic fluid, false positive L/S can be excluded in diabetic pregnancies.

Amniotic Fluid↗