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Biomedical subjects

K Tamura

Publications and source records attributed to K Tamura.

At least 1,315 records · Page 73Linked to original sources
PubMed1979

Lymphographic studies on protein-losing enteropathy.

Lymphographic studies were made on diseases of protein-losing in 19 cases, which include 9 cases of diseases of the digestive canal, 2 cases of constrictive pericarditis, and 8 cases of protein-losing enteropathy. Lymphographically in the diseases of the digestive canal no abnormal findings were detected, but in the constrictive pericarditis remarkable dilation and kinking of the thoracic duct with relatively poor congestion of the lumbar lymphatic vessels were observed. In the intestinal lymphangiectasia dysplasia of the lymphatics, passage disturbance of the thoracic duct with the congestive lumbar lymphatics, reflux to abdominal organs, oozing of contrast medium into the intestinal lumen were disclosed. Also experimentally lymphographic studies in thoracic duct-ligated dogs revealed the reflux to the mesenterial lymphatic system causing protein-losing into the intestine.

Animals↗
PubMed1979

Correlative evaluation of angiography and pancreatoductography in relation to surgery for cancer of the pancreas.

The results of preoperative angiograms and pancreatoductograms in 37 patients with cancer of the pancreas were correlated with each other, with the findings at laparotomy, and with survival times. Tumors which could not be detected by arteriography and/or pancreatography were resectable, except for those located in the uncinate process. Among the resectable tumors, those which were identified only by pancreatography were confined mostly to the parenchyma of the pancreas and were nearly 2 cm in size. Those patients were expected to have a long survival after total pancreatectomy. In contrast, those tumors which were diagnosed only by arteriography arose from the subcapsular portion of the gland or the uncinate process and showed macroscopic invasion to the capsule of the pancreas. These tumors, recurred within 1 year, despite total pancreatectomy. The resectable tumors showing both vascular and ductal invasion were more than 3 cm in size and extended far beyond the capsule of the gland, and patients with these tumors died within 1 year after operation. In this group no difference in survival time was seen among those treated by the Whipple procedure, those by total pancreatectomy, or those by resection of the total pancreas and the portal vein.

Adult↗
PubMed1978

Gastric mucosal barrier in the rats fed with protein deficient diet or treated with carbon tetrachloride.

The effects of protein deficient diet and liver damage on the gastric mucosal barrier were studied in 32 Sprague-Dawley rats. The animals were divided into 4 groups according to their dietary regimens, CCl4 induced liver damage and/or serotonin administration. Group 1 (control) was fed standard rat chow. Group II was fed a nonprotein diet for 2 weeks. Group III and IV were fed standard rat chow and given 1 ml of CCl4 per/Kg body weight intraperitoneally twice weekly for 12 weeks. Rats in Group IV were also injected with 20mg per/Kg of serotonin intraperitoneally 30 minutes prior to surgery. After pyloric ligation, an acid test solution composed of 100 mM HCl, 10mM NaCl, 5mM KCl and 5g per litre of PEG was instilled into the stomach and fluxes of Na +, K +, H + and Cl-ions across the gastric mucosa were measured. Compared to Group I, rats in Group II, III and IV demonstrated an increased net negative hydrogen flux (p less than 0.05). An increased net negative chloride flux (p less than 0.05) was also demonstrated in Group II and IV, but no increase was noted in Group III. There were no significant differences in fluxes of sodium and potassium ions. As mentioned above, a lack of protein in the diet, liver damage or both, renders the gastric mucosa of the rat more susceptible to injury. In the gastric mucosa of these rats, there have occurred more increase in the negative net fluxes of hydrogen and chloride ion, which may indicate the reduction of defence mechanism against a mucosal damage.

Animals↗
PubMed1978

Cardiac myofibril disorientation and Z band abnormalities in idiopathic cardiomyopathy. An electron microscope study.

Morphological alterations in idiopathic cardiomyopathy were examined and their clinicopathological significance was discussed. Six cases of congestive type and five of hypertrophic type chosen from 22 patients according to our strict criteria were examined by light and electron microscopy. The diameter values of cardiac muscle fibers were broadly distributed with multiple peaks in congestive cases and with 4 peaks in the hypertrophic cases in contrast to the 2 peaks in controls. The chief electron microscopic alterations consisted of myofibril disorientation and Z band abnormalities. The congestive cases were characterized by decreased and disdarrayed myofibrils (loose myofibril disorientation), wheras the hypertrophic cases by abundant myofibrils characteristically entangled with each other (tight myofibril disorientation). The Z band showed 3 types of abnormalities. Type 1 was characterized by widening, bifurcation and overriding of Z bands while the regular sarcomere was retained. The changes were more conspicuous in the hypertrophic cases than in the congestive cases. Type 2 was represented by clumping of Z band substance, and Type 3 by an interwoven form of electron dense fibers. Types 2 and 3 were seen in some of the hypertrophic and congestive cases. The tight myofibril disorientation and Type 1 of Z band abnormalities were considered important cytopathological clues for the diagnosis of the hypertrophic type of idiopathic cardiomyopathy.

Adult↗
PubMed1978

Functional alteration of islet cells after jejunal or ileal resection in dogs.

Functional alteration of the islet cells was investigated in dogs after the resection of different parts of the small intestine. Three weeks after jejunal or ileal resection, when the dogs might still have been in a catabolic state, insulin and pancreatic glucagon release in response to intravenously infused glucose and arginine was reduced. Three months after jejunal resection, both intravenous glucose tolerance and insulinogenic index in the intravenous glucose tolerance test were significantly below the preoperative values (P less than 0.001, P less than 0.05), while pancreatic glucagon release in response to arginine infusion release. This functional alteration three months after jejunal resection was similar to that seen in diabetes mellitus. On the other hand, three months after ileal resection, insulin and pancreatic glucagon release was almost normal. We conclude that the jejunum plays a more important role in the enteroinsular system than the ileum and that prolonged interruption of this enteroinsular axis can cause insular disorder and what could hypothetically be called enterogenic chemical diabetes, in view of the altered glucose tolerance test and the alteration in insulin secretory response.

Animals↗
PubMed1977

Follow-up study of gastrin response after resection of the jejunum and the ileum.

An experimental study was conducted on the effect of resection of the jejunum and ileum on gastrin release. The intravenous infusion of L. arginine in a dose of 0.5 g per kg body weight for 30 minutes proved to be most practical in evaluating gastrin release in addition to insulin and glucagon release. Serum gastrin levels in response to this dose of arginine were determined before and three weeks, three months and one year after resection of the jejunum and of the ileum. At three weeks, a significant increase in gastrin levels occurred in bothe the fasting state and after stimulation in dogs with either jejunum or ileum resection. At three months, the elevated gastrin response persisted only in those with jejunum resection. By one year, the gastrin levels had fallen in almost all dogs to approximately the preoperative levels.

Animals↗