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K Tamura

Publications and source records attributed to K Tamura.

At least 1,243 records · Page 69Linked to original sources
PubMed1984

[Role of the electrocardiogram in detecting transient myocardial ischemia].

Electrocardiographic evaluation of transient myocardial ischemia has three categories: detection, localization and severity, and prognostic evaluation. For the first category, the resting 12 leads electrocardiograms (RECG) were compared to those obtained by Holter monitoring (DECG) regarding ST segment changes. In 21% of patients with chest pain and normal RECGs, transient ST changes were disclosed by DECG. In 22% of patients with chest tightness or precordial discomfort and normal RECG, ST changes were disclosed by DECG. With onset of chest pain DECG showed ST changes in 56% of patients, and with tightness of the chest or precordial discomfort 35% of patients had DECG abnormalities. When DECG showed ST depression, cardiac complaints were accompanied in 25%, and when ST elevation occurred, they were accompanied in 45%. During maximal exercise test, ST changes appeared in all cases who complained chest pain. On the contrary, however, 48% of the patients complained chest pain at the time of the appearance of ST change. ST changes were examined in asymptomatic healthy persons. DECG showed ST changes in 17-25% in young persons. In the middle age persons, these were recognized from 15 to 35%. By treadmill exercise, young age group showed no changes in ST, whereas the middle age group showed the change in 4-8%. As to the localization, severity, and prognostic evaluation, the literatures were reviewed.

Adult↗
PubMed1984

[Clinical experience of sisomicin sulfate by intravenous drip infusion for the treatment of infection complicated by malignant disease].

Sisomicin sulfate (SISO) was used for the treatment of infections complicated by malignant diseases in 10 cases; 4 cases with suspicious sepsis, 2 with pneumonia, 2 with urinary tract infection, 1 with renal abscess and 1 with cholecystitis. SISO was administered by intravenous drip infusion at daily dose from 100 to 150 mg for 6 to 12 days, concomitantly with other antibiotics. Clinical results were as follows; Good in 2, fair in 5, poor in 3 cases. As to the side effects of SISO, cylindruria with aggravation of microscopic hematuria and elevations of GOT, GPT and A1-P were observed each one of them, respectively. The relationship to the SISO, however, was not clear. In view of the above results, the drip infusion of SISO may be useful for the treatment of serious infection complicated by malignant diseases.

Adult↗
PubMed1984

[A phase I study of 4'-epi-adriamycin, a new anthracycline anticancer agent].

A phase I study of 4'-Epi-Adriamycin, a new derivative of Adriamycin, was carried out in 36 cases with various malignant tumors, among which 30 cases were evaluable. Starting dose was 10 mg/m2 and this was increased up to 80 mg/m2. The dose limiting factor was leukopenia. Leukocyte nadir was reached about two weeks after administration and about nine days (mean) were needed for recovery. Other main side effects were anorexia, nausea vomiting, and alopecia. These side effects were mainly observed in cases given doses of over of 60 mg/m2. However, there were only a few serious cases suggesting that the clinical toxicities of 4'-Epi-Adriamycin were milder than those of Adriamycin. From the result of this study, it appeared that maximum tolerated dose of the drug is 80 mg/m2, and the dose recommended for the phase II study is 60 mg/m2 every three weeks.

Anorexia↗
PubMed1983

Treatment of erythroleukemia with anthracycline antibiotics and cytosine arabinoside.

The introduction of the anthracycline antibiotics and cytosine arabinoside have significantly improved the remission induction rate for patients with acute nonlymphocytic leukemia. Erythroleukemia (M6 by French-American-British classification) has long been considered to be resistant to chemotherapy. Since 1973 we have treated 14 patients with erythroleukemia with daunorubicin 45 mg/m2 or doxorubicin 30 mg/m2 for three days and cytosine arabinoside 100 mg/m2 by continuous infusion for 7 to 10 days. Six complete remissions (43%) were obtained with remission durations of 3+, 4+, 9, 13, 29+, and 35 months. While this remission rate is somewhat lower than that obtained with other types of acute nonlymphocytic leukemia, the combination of anthracycline antibiotics and cytosine arabinoside is clearly effective against erythroleukemia. Five patients treated before mid 1976 died soon after remission induction therapy was started. Four of these five patients were treated for 6 to 9 months with prednisone, halotestin, and/or splenectomy before remission induction chemotherapy was started and three of these patients died of systemic fungal infection, suggesting that these modalities of treatment may interfere with patient tolerance to remission induction therapy. It is suggested that erythroleukemia should be treated with intensive chemotherapy soon after the diagnosis is made.

Adolescent↗
PubMed1983

Precision in the first stage of the gastric carcinoma mass survey.

A new method of estimating false-negative rate (FNR) in gastric carcinoma mass surveys is reported. It is called the "ADC method", since estimation of FNR is based on "Accidentally Detected Carcinoma". ADC is a carcinoma detected by chance upon close examination because of abnormalities falsely pointed out in the first stage of the mass survey (mass screening) in a region other than the one in which carcinoma is located. This method was tested in the gastric carcinoma mass survey program conducted by the Hokkaido Anti-cancer Association. Overall FNR was estimated at 28.3%. The FNRs estimated by the ADC method appear more reasonable and reliable indicators of precision of the mass survey program. The ADC method is discussed in comparison with the previously used "follow-up study" and several advantages of this new method are presented.

False Negative Reactions↗
PubMed1983

Disturbances of the sleep-waking cycle in patients with vascular brain stem lesions.

Continuous polygraphic recordings of six patients with vascular brain stem lesions were evaluated to investigate the relationship between 1) the localization or extent of the lesions and the alteration of the sleep-waking cycle, and 2) the evolution of the clinical condition and the sleep-waking cycle. Absent REM sleep and severely disorganized NREM sleep were associated with extensive pontine lesions involving the pontine tegmentum. In "locked-in" syndrome, the neural mechanisms responsible for both REM and NREM sleep continued to function, but the sleep-waking cycle was disturbed and marked by sleep-onset REM periods. Lesions in the lower brain stem resulted in absent slow-wave sleep and sleep-onset REM, suggesting that vascular lesions may involve the neural mechanisms responsible for slow-wave sleep. In general, the acute stage of illness was marked by increased awakenings and time spent awake, absent REM sleep, and little or no slow-wave sleep. These results indicate that continuous polygraphic recordings can reveal severe abnormalities due to vascular lesions of the brain stem whereas the waking EEG can only detect mild abnormalities. Improvement in the organization of the sleep-waking cycle in successive polygraphic examinations is likely to be followed by an improvement of the clinical condition. Continuous polygraphic recording is thus a valuable prognostic indicator for vascular brain stem lesions.

Aged↗
PubMed1983

In vivo analysis of the suppressive effects of immunosuppressive acidic protein, a type of alpha 1-acid glycoprotein, in connection with its high level in tumor-bearing mice.

Suppressed concanavalin A response of spleen cells which appeared on Day 21 in C3H/He mice bearing methylcholanthrene-induced fibrosarcoma was attributed to macrophages. These macrophages were not only immunoglobulin and Thy 1.2 negative and mitomycin C resistant but were also found in the light-specific-gravity (1.077) fraction and were completely removed by carbonyl iron treatment. These suppressor macrophages, however, disappeared 4 days after surgical resection of the tumor, suggesting that the control mechanism originally resides in tumor tissues. Immunosuppressive acidic protein (IAP) levels in the sera of these tumor-bearing mice increased along with the appearance of these suppressor macrophages. Inasmuch as the suppressor macrophages obtained from the spleens of tumor bearers and cultured in vitro produced 4 times more IAP (88 ng/ml) than did resident macrophages, the elevated levels of IAP in the sera of tumor-bearing mice at the late stage might be explained partly by the appearance of suppressor macrophages. On the other hand, an i.v. administration of IAP (5 mg/mouse) into normal mice not only induced the same unresponsiveness of spleen cells to concanavalin A shown by tumor-bearing mice but also induced suppressor macrophages in the spleens of these mice. This fact may indicate that IAP elevation, even though artificial, triggers the induction of suppressor macrophages in the spleen or at least points to a keen correlation between the appearance of suppressor macrophages and increased IAP level in the serum.

Animals↗
PubMed1983

Endobronchial malignant lymphoma: unusual manifestations--a report of two cases.

Two unusual manifestations associated with endobronchial malignant lymphoma are reported. A 58-year-old white female was first seen with massive hemoptysis requiring blood transfusion and pneumonectomy for histiocytic lymphoma (large cell type). The second case was that of a 47-year-old black male treated previously for poorly differentiated lymphocytic lymphoma (medium-sized cell type) who had a relapse in the lungs. Increasingly copious sputum production led to respiratory distress which required extensive radiation therapy and chemotherapy for its control.

Bronchial Neoplasms↗
PubMed1983

Total body irradiation as a primary treatment for adult T-cell leukemia.

Adult T-cell leukemia (ATL) is an extremely difficult disease to treat. The median survival of patients with this disease has been reported to be only about 3 mo even with intensive treatment. We have treated five ATL patients (four males and one female, 42 to 72 yr of age) with total body irradiation (TBI). One patient who received 150 rad of TBI achieved complete remission and has been well without treatment for over a year. One hundred and thirty rad of TBI was administered to another patient, resulting in control of the leukocyte count at around 10,000/microliter and survival for 6 mo. Three patients received 100 rad of TBI. Only one of these patients has lived with leukemic cells for over a year without treatment. The other two patients relapsed rapidly and despite various kinds of treatment, such as a second course of TBI, extracorporeal irradiation of the blood, cytapheresis and combination chemotherapy consisting of pepleomycin, vincristine and a high dose of prednisolone, expired from pneumonia in 3 and 4 mo respectively. In all except the last two patients, thrombocytopenia and anemia developed and lasted for 2.5 wk to 3 mo and granulocytopenia occurred only in the patient who received 150 rad of TBI. Slight nausea and loss of appetite were noticed in one patient. It seems that 100 to 150 rad of TBI is effective against ATL, with acceptable side effects.

Adult↗