Search PubMed⌕ Search

Biomedical subjects

K Takatsuki

Publications and source records attributed to K Takatsuki.

At least 577 records · Page 32Linked to original sources
PubMed1981

Prognostic factors in multiple myeloma: parametric analysis in each abnormal protein type.

The prognostic significance of age, hemoglobin level, leukocyte and platelet counts, total protein and serum M-component concentrations, total protein other than M-component (TP-MC) concentration, serum uric acid level (all at the time of diagnosis), and interval from onset to diagnosis was studied retrospectively in 118 patients who died of multiple myeloma. Before analysis, the patients were separated into 7 subgroups, i.e., IgG IgA, Bence-Jones type, IgG.k, IgG.lambda, IgG with Bence-Jones proteinuria (IgG (+)), and IgG without Bence-Jones proteinuria (IgG (-)). Correlation analysis revealed that younger patients in the IgG.lambda and IgG(-) groups survived longer, that total protein positively correlated to survival in the IgG and IgG.lambda groups, that higher TP-MC concentration correlated to longer survival in the IgG, IgG.k, IgG(+), and IgG(-) groups and that higher uric acid levels adversely affected survival in the IgG.k group. All other factors were insignificant in all the subgroups. To assess the interrelationships among predictor variables, and to estimate their contribution to survival, a multiple regression analysis was performed. The resulting R2 values ranged from 0.28 (IgG) to 0.46 (IgG.lambda).

Hemoglobins↗
PubMed1980

Effects of magnesium ion on parathyroid hormone secretion in vitro.

In a well-defined in vitro perifusion system, the effects of extracellular magnesium concentration (Mg) on parathyroid hormone (PTH) secretion by bovine parathyroid tissue were examined. At Mg less than 0.8 mM, the ability of the glands to secrete hormone maximally in response to low calcium (Ca) stimulation was progressively impaired. Low Mg also impaired the ability of isoproterenol, dibutyryl cyclic AMP and theophylline to stimulate hormone release. The defect in hormone release at low Mg observed in vitro was analogous to the well-documented inhibition of secretion observed in vivo. Increases in Mg from 0 to 0.8 mM rapidly repaired the defect in hormone secretion. At Mg above 1.0 mM there was a Ca-like effect on hormone release, with a progressive decrease in secretion at increased Mg. Although its mechanism is not yet clear, the low Mg effect appears to impair principally the process of hormone release rather than its biosynthesis or storage.

Animals↗
PubMed1980

Topographic organization of the projection from the forebrain subcortical areas to the hippocampal formation of the rat.

Using the technique of iontophoretic microinjection of horseradish peroxidase, the present study disclosed the complexity and high degree of the topographic organization in the forebrain subcortical afferents to the different regions of rat hippocampus, e.g. diagonal band, posterior (PH), dorsomedial and rostral lateral hypothalamic nuclei chiefly project to the rostrodorsal part (DRA) and caudal gyrus dentatus including CA3, the supramammillary area predominantly to the rostroventral area (VRA), the area lateral to PH to the DRA and VRA, substantia innominata and some thalamic nuclei (n. reuniens, n. lateralis thalami, n. anterior ventralis and n. lateralis thalami pars posterior) to the dorsal subiculum, respectively.

Animals↗
PubMed1980

Fc gamma and Fc mu receptors in B cell neoplasms. Correlation to the developmental stages.

Membrane receptors for the Fc portions of IgG (Fc gamma receptor) and IgM (Fc mu receptor) on leukemic cells in B cell neoplasms in various developmental stages were studied. In 6 out of 7 patients with B-CLL, leukemic cells had both receptors. In macroglobulinemia, leukemic cells had one or the other of Fc gamma and Fc mu receptors. In plasma cell leukemia and plasmacytoma, malignant cells had neither Fc gamma or Fc mu receptors. The disappearance of Fc receptors appears to be associated with B cell differentiation.

Adult↗
PubMed1980

IgG heavy chain allotypes (Gm) in autoimmune diseases.

Serum samples from 100 patients with myasthenia gravis, 322 with Graves' disease, 113 with Hashimoto's disease, 132 with systemic lupus erythematosus (SLE), 192 with insulin-dependent juvenile diabetes mellitus, 83 with Behçet's syndrome, 73 with psoriasis vulgaris, 258 with leprosy, 112 with Duchenne progressive muscular dystrophy and 343 non-related normal controls were studied for Gm allotypes. The incidence of Gm phenotypes with Gm(2) was significantly increased in patients with myasthenia gravis. Graves' disease, Hashimoto's disease, and high in SLE patients. The Gm1,2,21 haplotype was increased in patients with myasthenia gravis (chi 2 = 34 . 08, corrected P less than 0 . 001), Hashimoto's disease (chi 2 = 12 . 39, corrected P less than 0 . 05), Graves' disease (chi 2 = 8 . 65, corrected P less than 0 . 05), and SLE (chi 2 = 6 . 41, 0 . 1 greater than corrected P greater than 0 . 05). The total chi-square for the four different Gm haplotypes was significantly increased in patients with myasthenia gravis (chi 2 = 44 . 46, corrected P less than 0 . 001), SLE (chi 2 = 20 . 70, corrected P less than 0 . 005), Hashimoto's disease (chi 2 = 17 . 03, corrected P less than 0 . 025), and Graves' disease (chi 2 = 11 . 87, corrected P less than 0 . 025). Our data suggest the presence of Gm-associated pathogenic polygenes in certain autoimmune disorders.

Autoimmune Diseases↗
PubMed1980

Immunologic studies on Werner's syndrome.

Five patients with Werner's syndrome were studied to elucidate the relationship between the immune system and the ageing process. Three of five patients had neoplasms such as fibrosarcoma, meningioma and thyroid adenoma but none of the five patients manifested symptoms and signs suggestive of typical autoimmune disorders. Most immunohaematological data were normal; however, two patients exhibited diminished lymphocyte functions such as a significant (P less than 0 . 05) reduction in pokeweed mitogen (PWM) induced B cell differentiation, a slightly decreased response to Con A- or mitomycin-treated allogeneic lymphocytes and naturally occurring serum antibody to T cells. While these immunological changes were quantitatively small, subnormal levels of immune functions were detected. Cultured fibroblasts exhibited a decrease in clonal growth potentials and elongation of newly synthesized DNA, a decreased expression of HLA antigens, and a diminished secretion of beta 2-microglobulin.

Adult↗
PubMed1979

Adult T cell leukemia. Histological classification and characteristics.

Adult T cell leukemia was classified into two distinct types, monomorphic and pleomorphic, according to their histological and cytological features. The former type is composed of uniform neoplastic cells with round or slightly indented nuclei without any marked deformation. The latter type, on the other hand, occupies a unique position in lymphocytic leukemias with the following characteristics: a) onset in adulthood, b) an acute and subacute course, c) well-differentiated T cell origin of the neoplastic cells, d) pleomorphism of the neoplastic cells with markedly deformed nuclei, e) diffuse proliferation of the neoplastic cells without nodular pattern, f) histologically heterogeneous features of lymph nodes frequently admixing a cluster of normal lymphocytes, proliferation of macrophages and dendritic cells, and well-developed high endothelium venules, g) high incidence of skin lesions due to the infiltration of neoplastic cells, and h) exclusively limited localization of patients' birth places.

Adult↗