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Biomedical subjects

K Takagi

Publications and source records attributed to K Takagi.

At least 793 records · Page 44Linked to original sources
PubMed1981

Hemihidrosis due to skin pressure with particular remarks on the intensity and area of the pressure stimuli.

Sweating of symmetrical areas of the torso was measured by means of both the filter paper method and electrohygrometric method. Spontaneous sweating rates of the left and right side of the upper and lower chest and the back were statistically highly correlated. Reduction of sweating by pressure application to the unilateral subaxillary region ("pressure hemihidrosis") was studied quantitatively with 12 combination of pressure stimuli, i.e., 1, 2, 3 and 4 kg weights applied to disks with a surface area of 2, 6 and 16.6 cm/, respectively. The amount of reduction in sweating rate was proportional to both the intensity and the surface area to pressure applied. It was revealed that hemihidrotic effects induced from the unit area of pressure stimulation was statistically highly correlated to the pressure intensity.

Adult↗
PubMed1981

Lysosomal enzyme in endotoxin shock.

Lysosomal enzymes are released in the blood stream in various types of shock. The role of the released enzymes in the development of irreversible shock is still controversial. The present study was undertaken to determine the effect of the administration of lysosomal enzymes in normal rats and rats treated with endotoxin. Lysosomal enzymes were prepared from the isologous liver. They were given either intravenously or intraperitoneally to normal rats. No hemodynamic effect was observed. They were also given to the rats that received the lethal dose of endotoxin. No hemodynamic effect was found in this group. The survival time and the time course of the blood pressure to death did not change. The lysosomal enzyme preparation was given to the rats that received various dosages of endotoxin of less than LD190. The mortality rate of the rats that received endotoxin was not modified by the administration of the lysosomal enzyme preparation. These results indicate that lysosomal enzymes released into the blood in endotoxin shock may not contribute significantly to the irreversibility of shock.

Acid Phosphatase↗
PubMed1980

A comparative study of serum alpha 1-microglobulin and beta 2-microglobulin levels in cancerous and other diseases.

The levels of serum alpha 1-microglobulin in 60 normal persons and in 191 patients suffering from a variety of benign and malignant disorders were determined by an enzyme immunoassay, and these values were compared with the levels of beta 2-microglobulin. A discrepancy between the serum levels of these proteins was found in hepatobiliary disorders; that is, an increased serum level of beta 2-microglobulin was observed in 73.9%, while in only 4.3% was there an elevation of alpha 1-microglobulin. In particular, alpha 1-microglobulin levels in patients with liver cirrhosis were well below the normal range, while beta 2-microglobulin levels were elevated. Elevated levels of both proteins were noted in patients with some impairments of renal function, particularly in chronic renal failure, and in immunological diseases. In 81 patients with neoplastic diseases, a high alpha 1-microglobulin value was found in only 15 patients (16.4%), while a high beta 2-microglobulin value in 62 patients (76.5%). The serum levels of both alpha 1-microglobulin and beta 2-microglobulin were especially high in plasma cell dyscrasia with Bence Jones protein, but other neoplastic diseases were mostly associated with beta 2-microglobulin elevation alone.

Adult↗
PubMed1980

Histochemical observations of polyglucose synthesized by enzyme activities in human gastric carcinoma.

Polyglucose particles histochemically synthesized from glucose 1-phosphate by phosphorylase and branching glycosyltransferase were observed in the gastric carcinoma cells, in intestinal metaplastic epithelium of the gastric mucosa and in fetal epithelium of the fetal gastric mucosa by light and electron microscopical studies. Light microscopical observations resembled those in previous reports. As for the electron microscopical observations, in gastric carcinoma cells, the polyglucaose synthesizing area were expansively widened by a deposition of synthesized polyglucose particles. Three patterns of their intracellular distribution, (Focal type, scattered type and singly deposited type) were observed. Besides, two types of polyglucose particle were synthesized. One type appeared as monoparticles which were relatively similar in size and the other type appeared as rosette-like structures which varied in size. Larger polyglucose particles which resembled the polyglucose particle synthesized in the fetal epithelium were observed among them. In the intestinal metaplastic epithelium, polyglucose particles which were similar in size were synthesized in narrow focal areas of the cytoplasmic matrix. The distribution, shape and size of polyglucose particles synthesized in the carcinoma cells were irregular as compared with those in the intestinal metaplastic elpithelium. It seems that these irregularities were due to the influence of enzymne deviation caused by carcinoma.

1,4-alpha-Glucan Branching Enzyme↗
PubMed1980

Human alpha 1-microglobulin levels in various body fluids.

alpha 1-Microglobulin levels in serum and urine were estimated by using single radial immunodiffusion, resulting in the following mean values: umbilical cord blood serum, 40.6 mg/l; normal adult serum, 44.2 mg/l; and normal urine, 5.7 mg/24 h urine volume. Slightly higher levels of serum alpha 1-microglobulin were found in infants and the aged. Serum and urine alpha 1-microglobulin levels in patients with renal failure, however, were greatly increased, mean levels being 231.5 mg/l and 100.7 mg/24 h urine volume, respectively. Serum alpha 1-microglobulin levels in these patients correlated well with both serum creatinine and beta 2-microglobulin levels. Serum alpha 1-microglobulin level did not correlate positively with serum levels of other plasma proteins, such as alpha 1-antitrypsin, haptoglobin, complement, etc. Ouchterlony immunodiffusion also revealed the presence of alpha 1-microglobulin in synovial fluid, ascites, pleural effusion, amniotic fluid, cyst fluid, and cerebrospinal fluid. The levels of alpha 1-microglobulin in these fluids were measured by single radial immunodiffusion, except that its level in cerebrospinal fluid was measured by radioimmunoassay. Mean alpha 1-microglobulin concentration was 20.8 mg/l in synovial fluid, 28.7 mg/l in ascites, 21.5 mg/l in pleural effusion, 2.7 mg/l in amniotic fluid, 8.2 mg/l in cyst fluid, and 42.3 ng/ml in cerebrospinal fluid.

Alpha-Globulins↗