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Biomedical subjects

K Tajima

Publications and source records attributed to K Tajima.

At least 469 records · Page 26Linked to original sources
PubMed1984

Elevated serum thyroglobulin as a manifestation of acute haemorrhage into the thyroid gland.

Clinical observations and serial determinations of serum thyroglobulin (Tg) were made in five patients with acute haemorrhage into the thyroid gland. Fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum T4 and T3 were normal. Although all patients showed an increase in serum Tg, this was most obvious in three subjects and it gradually decreased as the nodule became smaller. There was no correlation between the serum Tg concentration and the nodular size. Acute haemorrhage into the thyroid gland should be added as one of the causes to increase serum Tg concentrations.

Acute Disease↗
PubMed1984

The differential diagnosis of cystic neck masses by the determination of thyroglobulin concentrations in the aspirates.

Thyroglobulin (Tg) concentrations in the aspirates of various types of cystic neck masses were measured by RIA to assess the usefulness of this determination in differential diagnosis. The subjects consisted of 16 patients, whose final diagnoses were all established on the basis of operative results; three patients had follicular thyroid adenomas (F-Ad), 11 had papillary thyroid carcinomas (P-Ca), one had a thyroglossal duct cyst (TDC) and one had a lateral cervical cyst (LCC). Tg concentrations in the cyst fluids of F-Ad and P-Ca were very high (0.042-2.83 mg/ml) compared with serum Tg concentrations. There was no difference in Tg concentrations in the fluids of P-Ca between primary lesions (n = 5) and metastatic lesions (n = 6). On the other hand, Tg concentrations of TDC and LCC were very low (less than 100 ng/ml). Difficulty was experienced in diagnosing three patients, even though they had been examined by all nonsurgical diagnostic techniques. However, an occult thyroid carcinoma with lymph node metastasis was diagnosed by demonstrating a high Tg concentration in the aspirate of the cystic lymph node. T3 concentrations in cyst fluids of F-Ad were higher than those of P-Ca. T3 concentrations in the fluids of P-Ca, TDC and LCC did not differ, and were similar to serum T3 levels. Cytology of cyst fluids was positive in four of 10 patients examined with P-Ca. In conclusion, we can clearly confirm the thyroid origin of a cystic neck mass by demonstrating a high Tg concentration in the aspirate. This is especially useful for diagnosis in patients with thyroid carcinoma, including occult thyroid carcinomas with cystic lymph node metastasis.

Adenoma↗
PubMed1984

Thyrotoxic myopathy associated with subacute thyroiditis.

We report a case of subacute thyroiditis complicated by thyrotoxic myopathy. Previously thyrotoxic myopathy has been described as being associated with Graves' disease. The patient in this study was a 35-year-old man who developed proximal dominant muscular weakness and atrophy during the course of subacute thyroiditis. His myopathic symptoms regressed as his serum thyroxine and triiodothyronine levels returned to normal, however it took a relatively long period of time for them to do so. This suggests that marked myopathy may develop even in cases of subacute thyroiditis if the thyrotoxic state persists for a long period of time.

Adult↗
PubMed1984

HLA antigens and adult T-cell leukemia virus infection: a community-based study in the Goto Islands, Japan.

In order to study the genetical susceptibility to infection by adult T-cell leukemia virus (ATLV), which is considered to be a main causative agent of adult T-cell leukemia (ATL), the HLA profile of persons with antibody against ATLV-associated antigen (anti-ATLA) was compared with that of antibody-negative persons in villages A and B of the Goto Islands, a typical ATL endemic area in Kyushu, Japan. The frequency (29%) of HLA-B7 in persons with anti-ATLA was significantly higher than that (8%) in anti-ATLA negatives (corrected X2 = 7.73, p less than 0.01) in one village while the frequency of HLA-B7 was around 10% in both positive and negative persons in the other village. These results do not support or deny the possibility of the existence of individuals who are genetically susceptible to ATLV infection in ATL endemic areas of Japan.

Adult↗
PubMed1984

[A clinical survey of bacteria isolated from urine specimens of patients with various urological disease].

We have clinically surveyed the distribution and disk sensitivity of bacterial strains obtained from urine of patients with various urological disease at our department during three (1975-1977) and four (1980-1983) years. Escherichia coli was the most frequently isolated (29.4%) from the outpatients, followed by Staphylococcus epidermidis (17.5%), Pseudomonas cepacia (11.2%) and Serratia marcescens (11.2%). Pseudomonas cepacia was the most frequently isolated (28.0%) from the inpatients, followed by Staphylococcus epidermidis (16.3%) and Serratia marcescens (15.9%). Pseudomonas cepacia which has been increasing was first isolated in 1977 and Serratia marcescens in 1976. They have become the main bacteria causing infections in our hospital. Pseudomonas cepacia was frequently isolated after postoperative prophylactic chemotherapy and Serratia marcescens in the late period of admission. The majority of Pseudomonas cepacia was resistant to all agents except chloramphenicol and doxycycline. Serratia marcescens was also resistant except to gentamicin and doxycycline. In Escherichia coli species, resistant strains increased gradually but they have good sensitivity to gentamicin, dibekacin, colistin and doxycycline. Staphylococcus epidermidis isolated from outpatients had good sensitivity to all agents but increased in incidence of resistant strains isolated from inpatients.

Anti-Bacterial Agents↗
PubMed1983

Reaction of biological phenolic antioxidants with superoxide generated by cytochrome P-450 model system.

Scavenging of a superoxide and simultaneous formation of free radicals with phenolic antioxidants were investigated with cobalt and iron tetraphenylporphyrin-thiolate complexes as models of P-450 enzymes. The kinetics of decay of the superoxide and development of free radical ESR signal intensities were studied. Based on a molecular orbital calculation of the hyperfine splitting, the radical species generated were confirmed to be those of phenoxyl radicals. The biological implication of superoxide, including active oxygen forms, for the reaction was discussed.

Antioxidants↗