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Biomedical subjects

K Sone

Publications and source records attributed to K Sone.

64 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease.

Dipyridamole has been widely used in Japan to treat patients with a coronary aneurysm resulting from Kawasaki disease, but its effect in these patients has not been established. In the present study we assessed the effect of dipyridamole on the coronary arteries of patients with a history of Kawasaki disease by measuring the diameter of the coronary arteries and by quantifying the disappearance time of contrast medium (runoff time) on coronary angiography. Intravenous injection of dipyridamole increased the diameter of nondilated arteries by 7.9%. Its effect on the diameter of dilated coronary arteries (coronary aneurysm) was less than 3% (p < 0.01). Runoff time of dilated coronary arteries was significantly (p < 0.01) greater than that of nondilated coronary arteries. Dipyridamole accelerated runoff time not only in nondilated coronary arteries (p < 0.01) but also in coronary arteries with various degrees of dilatation (p < 0.01). We conclude that dipyridamole increases blood flow in coronary arteries without dilating the proximal aneurysm in children with a history of Kawasaki disease.

Child↗
PubMedDate not supplied

Cause of closed suction drainage tube obstruction and its prevention using a tube coated on the inside with a silicone gel drug delivery system.

In experimental and clinical studies we showed that obstruction of closed suction drainage tubes is often caused by clots. To prevent this we describe a tube coated on the inside with a silicone gel drug delivery system, which releases anticoagulant drugs. It prevents coagulation and liquefies blood clots present in the tube. This device should thus find application as a tube for continuous suction drainage systems.

Anticoagulants↗
PubMedDate not supplied

Hydration and occlusion treatment for hypertrophic scars and keloids.

In 31 patients with hypertrophic scars or keloids, a side by side test was carried out to check the efficacy of an occlusive dressing technique using cream which did not contain silicone oil, versus a simple application of vaseline, used as a control. In all cases, the cream treated areas of scar and keloid demonstrated a remarkable improvement over that of the vaseline treated area. These findings strongly suggest that the mechanisms of hydration and occlusion are the main basis of the therapeutic action of this method in treating hypertrophic scars and keloids.

Adolescent↗
PubMedDate not supplied

Beneficial effects of silicone cream on grafted skin.

The clinical effects of silicone cream were compared to vaseline on 27 patients with split (14 cases) and full thickness (13) skin grafts. Silicone cream occlusive treatment resulted in significantly less pigmentation and hardness in 21 out of 27 cases (78%), less marginal scar hypertrophy and redness in 10 and 7 cases respectively (37 and 26%), and in an even narrower marginal scar in 6 cases (22%). In nine cases of the split skin graft, fewer wrinkles resulted in the silicone cream treated lesion.

Adolescent↗
PubMedDate not supplied

The relationship between prostaglandin E1 applied area and flap survival rate.

Using a silicone gel sheet continuous drug delivery system containing Prostaglandin E1 (PGE1), the relationship between flap survival rate and the site of drug application was studied. Skin flaps measuring 2 x 9 cm were raised on the dorsum of rats, and divided into 3 areas. Area 1 was within 3 cm of the flap tip, area 2 was between 3-6 cm from the flap tip including the critical zone, and area 3 was the portion within 4 cm of the flap base. Further, area 4 was a strip of skin around the flap, 1 cm in width. Compared to the control group, a significant increase in flap survival rate was seen only when PGE1 was administered to area 2 (p < 0.01, t-test). Specimens injected with dye intravascularly showed an increase in the number of thick vessels in area 3, when PGE1 was applied only to area 3. However, when PGE1 was applied to area 2, there was no significant vascular increase in area 3. Instead, an extensive network of fine vessels was observed in area 2.

Alprostadil↗
PubMedDate not supplied

Auditory brainstem responses in congenital heart disease.

To evaluate the effect of chronic hypoxemia on brainstem maturation, auditory brainstem responses were examined in 70 children (32 with and 38 without cyanosis) who had congenital heart disease. Ninety-one age-matched normal children served as controls. At 1-3 months of age, the I-V interpeak latencies of cyanotic infants (mean +/- S.D.; 5.17 +/- 0.17 ms) were more prolonged than were those of controls (4.95 +/- 0.11 ms) and those without cyanosis (4.84 +/- 0.22 ms; P < .05; P < .01). At 4-11 months of age, the I-V interpeak latencies of cyanotic infants (4.85 +/- 0.13 ms) were more prolonged than were those of controls (4.67 +/- 0.19 ms) and those not experiencing cyanosis (4.5 +/- 0.17 ms; P < .05; P < .01). In the cyanotic children, there was a significant negative correlation between the I-V interpeak latency and oxygen partial pressure (P < .01) or oxygen saturation (P < .05). Three of the 70 patients (4.3%) with congenital heart disease had absent auditory brainstem response. These data indicate that chronic hypoxemia may be one of the factors in retarded brainstem maturation.

Brain Stem↗