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Biomedical subjects

K Smith

Publications and source records attributed to K Smith.

At least 577 records · Page 32Linked to original sources
PubMed1976

An ultrastructural study of heterokaryons derived from Theileria parva-infected bovine lymphoblasts and Ehrlich ascites tumour cells.

An ultrastructural study was made of Sendai virus induced heterokaryons derived from Theileria parva-infected lymphoblasts and Ehrlich ascites tumour cells. When fusion occurred, parasites were successfully integrated into the cytoplasm of the resulting heterokaryons where they appeared as morphologically normal macroschizonts. Homokaryon formation was also noted. This occurred frequently between Ehrlich ascites tumour cells and rarely with lymphoblasts. A small proportion of heterokaryons contained altered forms of T parva showing nuclear components, vesicular structures and paired organelles similar to the microshizont stage of the parasite.

Animals↗
PubMed1975

The internal sphincter and Lord's procedure for haemorrhoids.

Anal pressure and motility have been measured in 56 patients with haemorrhoids and 40 asymptomatic subjects. The anal pressure of patients with haemorrhoids (93-6 cm H2O) was very significantly higher than that of the controls (66-8 cm H2O; P less than 0-001). Ultra-slow pressure waves (amplitude 25-100 cm H2O, frequency 0-9-1-6/min) were present in 39 per cent of patients with haemorrhoids, but in only 7-5 per cent of the controls (P less than 0-001). Ultra-slow waves are present under anaesthesia with the voluntary muscles paralysed and are associated with the highest anal pressure, and so, represent abnormal activity of the internal anal sphincter. Measurements after anal dilatation showed complete abolition of ultra-slow wave activity and a very significant drop in pressure. One year after dilatation 19 patients had a mean anal pressure of 62 cm H2O. Very good results were obtained unless the haemorrhoids were so large that they prolapsed at times other than defaecation. Lord's procedure is a rational treatment since it corrects an underlying overactivity of the internal sphincter.

Adult↗
PubMed1973

Studies of trans-3-methyl-2-hexenoic acid in normal and schizophrenic humans.

The report that sweat of certain schizophrenics contains the branched chain fatty acid, trans-3-methyl-2-hexenoic acid (TMHA), stimulated an investigation to evaluate the relationship between this fatty acid and schizophrenia. A sensitive and specific gas-liquid chromatography-mass spectroscopic procedure was developed for analyzing biological fluids for TMHA. Analysis of sweat samples from normal and schizophrenic subjects indicated that the sweat of both groups contains comparable quantities of this fatty acid. In addition, the fate of intravenously administered (14)C-labeled TMHA was shown to be similar in normal and schizophrenic subjects. It is concluded that there is no relationship between TMHA and schizophrenia.

Caproates↗
PubMed1972

Genetic studies on plasmid-linked cadmium resistance in Staphylococcus aureus.

The genetic basis of cadmium resistance conferred by three penicillinase plasmids, PI(524), PI(258), and PII(147), of Staphylococcus aureus was examined by mutation, recombination, and deletion analysis. Three separate loci were identified: cadA, responsible for high-level resistance; cadB, giving a low-level resistance, nonadditive to cadA; and mad, a locus marginally decreasing the cadmium resistance of plasmid-positive staphylococci. The loci cadA and mad were present on all three plasmids, but cadB was only found on PII(147). Spontaneous deletions of mad involved up to three-fourths of the plasmid genome, which allowed derivation of a partial deletion map of PII(147), a plasmid with a contour length of 10.9 mum, corresponding to a molecular weight of 20.4 x 10(6).

Alkanesulfonates↗