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Biomedical subjects

K Smith

Publications and source records attributed to K Smith.

At least 289 records · Page 16Linked to original sources

The prevalence and costs of psychiatric disorders and learning disabilities.

BACKGROUND: The economic burden of psychiatric disorders and learning disability is assessed in order to aid decisions on priorities for research funding. METHOD: A wide variety of data sources both on prevalence and on the usage and costs of relevant services were used to measure the economic burden of each condition. RESULTS: Despite methodological problems and problems with the data, an attempt is made to estimate the relative economic burden imposed by each condition. No attempt is made to sum up the costs for each condition across the agencies and individuals involved. CONCLUSIONS: Our findings show that learning disability, schizophrenia and neurotic conditions (including depression) are major burdens on the National Health Service; senile dementia and depression in older people impact largely on local authority social services. Senile dementia, schizophrenia and learning disability are also heavy charges on the social security system. It is also notable that the large numbers with less severely disabling neurotic disorders generate a burden that, according to our figures, is comparable to schizophrenia and other psychotic disorders.

Adolescent↗

Nucleotide and predicted peptide sequence of feline interferon-gamma (IFN-gamma).

Interferon gamma is a pleiotropic cytokine which is now recognised as an important modulator of the immune response. We now report the cloning and sequencing of feline interferon gamma cDNA which was generated by the polymerase chain reaction. At the nucleotide level feline ifn-gamma shares 78% and 63% homology with human and murine cDNA equivalents. At the amino acid level the feline IFN-gamma shares 63% and 43% homology with human and murine homologs respectively.

Amino Acid Sequence↗

The chief scientist reports ... The Scottish case control study of childhood leukaemia and cancer: methodology and environmental measures of exposure.

This major case control study of childhood leukaemia and other cancers aims to identify risk factors and test prior aetiological hypotheses related to exposure to ionising radiation, chemicals, electromagnetic fields and patterns of infections in early life. This paper describes the comprehensive study methodology and demonstrates the efficacy of collecting traditional epidemiological data in conjunction with direct measures of exposure. The data collection phase is incomplete but the preliminary descriptive results indicate that an optimal sample of children will be included in the analyses. This complete and representative data set will provide a unique opportunity for investigating the causes of malignant disease in Scottish children, with the additional weight of exposure measures to complement the body of interview and medically abstracted information.

Adolescent↗

Orbital complications of functional endoscopic sinus surgery.

Sinus disease and its surgical treatment carry the risk of orbital complications, including the possibility of blindness. These complications apply to traditional sinus procedures and the more recent endoscopic approach. Two recent endoscopic cases resulted in eye complications, and the lessons learned in their management are herein shared. One case was complicated in the immediate postoperative period with an orbital haematoma that required urgent decompression through lateral canthotomy/cantholysis. The second case involved a patient who complained of visual changes starting 5 days after an uncomplicated procedure. Ophthalmologic consultation diagnosed amblyopia, which he had preoperatively. A preoperative visual assessment is highly recommended to avoid possible medicolegal misadventures.

Adult↗

The nephrology nursing practice environment: responding to changes.

In this session, Ms. Smith and Ms. Sims outlined the practice milieu for today's nephrology nurse. The speakers portrayed the end stage renal disease (ESRD) environment by defining the providers of care, outlining the changing characteristics of the recipients of care, and describing the effects of health care reform.

Health Care Reform↗

Nurse's role in achieving patient outcomes.

Nephrology nursing's influence on patient outcomes has as many facets as there are practice roles in nephrology nursing. These speakers discussed the impact on patient outcomes from a variety of practice perspectives. The roles of administrator, educator, staff nurse, government nurse, research nurse, and corporate nurse are each described.

Humans↗

Bringing epilepsy care into the 1990s. The epilepsy liaison service.

1. Dissemination of accurate information to all healthcare professionals and clients is vital if standards of care in epilepsy management are to improve. 2. Epilepsy audit is a vital step in raising the profile of epilepsy in general practice and in improving care. 3. People with epilepsy in primary and secondary care need realistic treatment plans and goals. 4. Practice nurses have an essential role to play in devising treatment plans and goals. 5. With a greater effort many people with epilepsy who are still having seizures can become seizure-free.

Continuity of Patient Care↗

Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.

PURPOSE: To use proton MR spectroscopy in patients with neurofibromatosis type 1 to determine: (a) the spectroscopic characteristics of hamartomas and compare them with that of gliomas; (b) whether differences exist between patients with and without learning disabilities; and (c) spectroscopic patterns in normal-appearing brain (by MR imaging) in patients with and without focal lesions. METHODS: Seventeen proton MR spectroscopy volumes were obtained in 10 patients with neurofibromatosis type 1 (including hamartomas, N = 7; normal-appearing brain, N = 10). Seven patients had learning disorders, and 3 were mentally normal. Ten healthy volunteers and 10 patients with pathologically proved gliomas (all grades) were also examined. N-Acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios were calculated for all samples. RESULTS: (a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas. Hamartomas showed N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios similar to those of healthy volunteers. (b) No significant differences in N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios were found in patients who had neurofibromatosis type 1 with and without learning disabilities. (c) N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios were similar for patients who had neurofibromatosis type 1 with and without focal hamartomas and in healthy volunteers. CONCLUSIONS: (a) Hamartomas have a proton MR spectroscopy pattern different from that of glioma and similar to that of normal brain. (b) As performed in this study, proton MR spectroscopy did not show significant differences in patients who had neurofibromatosis type 1 with and without learning disabilities. (c) Patients who have neurofibromatosis type 1 with and without hamartomas seem to have normal intervening brain by proton MR spectroscopy when compared with healthy volunteers.

Adolescent↗

The 20-prism-dioptre base-out test: an indicator of peripheral binocularity.

OBJECTIVE: To assess the ability of the 20-prism-dioptre base-out test to detect the presence of peripheral fusion in children too young to undergo formal sensory testing. DESIGN: Case series. SETTING: Pediatric ophthalmology service at the Children's Hospital of Western Ontario, London. PATIENTS: Eighty orthophoric patients (mean age at presentation 19 months [range 4 to 50 months]) with a family history of strabismus or with a diagnosis of pseudostrabismus, blocked tear duct or chalazion, followed for an average of 36 (range 6 to 129) months, and 41 patients with surgically corrected infantile esotropia (mean age at testing with the 20-PD base-out test 21 months [range 9 to 50 months]), followed for an average of 53 (range 14 to 117) months. INTERVENTIONS: Twenty-PD base-out test and red-green Worth four-dot test at near (0.3 m). OUTCOME MEASURE: Presence of peripheral fusion. RESULTS: The 20-PD base-out test had a positive predictive value of 100% in detecting peripheral fusion in the orthophoric patients and 93% (95% confidence interval [CI] 82% to 100%) in the patients with surgically corrected infantile esotropia. CONCLUSIONS: Although the 20-PD base-out test had a negative predictive value of 21% (95% CI 0% to 43%), a positive response remains a useful indicator of peripheral binocular single vision in children too young to undergo more formal sensory testing.

Child, Preschool↗

Thyroid-induced changes in the growth of the liver, kidney, and diaphragm of neonatal rats.

Eu-, hypo- and hyper-thyroid rats were studied 12 days postpartum. Hypothyroidism was induced by administering propylthiouracil (PTU) via the mother's drinking water between late gestation and throughout lactation. This procedure effectively blocked the normal early postnatal surge of T3 and T4. In contrast, hyperthyroidism was induced in the young pups by daily injections of T4 from day 3 postpartum. The effects of these experimental manipulations of thyroid status on the rates of protein turnover and growth of the liver, kidney, and diaphragm were studied and compared with measurements made on appropriate euthyroid control tissues. Tissue rates of protein synthesis were decreased in response to hypothyroidism with consequent growth retardation of all three tissues and the whole animal. In contrast, the three body tissues responded very differently to the induction of hyperthyroidism. Hepatic rates of protein synthesis and growth were completely unaffected by thyroid excess. The response of the diaphragm was essentially the reverse of that seen with hypothyroidism, i.e., the enhanced rates of protein synthesis and protein degradation leading to muscle hypertrophy. The rates of protein turnover in the kidney were also increased, but unlike the diaphragm the net result was renal atrophy. Clearly, thyroid hormones influence the normal rapid growth of the neonate and its individual tissues. However, beyond a certain concentration the threshold of responsiveness to these hormones seems to vary between individual tissues.

Animals↗

Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections.

Fiber diameter variability, acetylcholinesterase staining properties, and average fiber diameter were determined 5 weeks after varying doses of botulinum A toxin were administered into albino rabbit longissimus dorsi muscle. The average fiber diameter within the muscle appeared to be a function of the dose of botulinum toxin injected. Fiber diameter variability correlated with the dose of botulinum toxin administered. Both fiber diameter variability and acetylcholinesterase spread characteristics showed a distinct diffusion gradient over a defined field within a muscle. At lower doses (1 IU), collapse of the diffusion gradient occurred over a 15-30-mm segment of muscle. At higher doses (5-10 IU), diffusion of botulinum A toxin effect occurred throughout the entire muscle with no apparent end point. This study demonstrated that botulinum A toxin produces a gradient of denervation in a given muscle and that both the magnitude of denervation and the extent of the gradient are dose dependent. Furthermore, both muscle fiber diameter variability and acetylcholinesterase staining were useful as measures of chemodenervation.

Acetylcholinesterase↗

The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients.

Epidermal growth factor receptor (EGFR) and estrogen receptor (ER) were assayed by ligand binding in tumors from 370 patients with primary breast carcinoma with a median follow up of 18 months. Forty seven percent (175/370) and 57% (210/370) of tumors had > 20 fmol/mg and > 10 fmol/mg of EGFR and ER respectively. There was a highly significant inverse relationship between EGFR and ER (p = 0.0032). There was also a significant association between EGFR and patient age (p = 0.0006) but not correlation between EGFR and lymph node status, tumor grade, or tumor size (p = 0.104, p = 0.198, and p = 0.085 respectively). In a univariate analysis of all patients, EGFR expression was not associated with a significant reduction in overall survival (OS). However, there was a significant decrease in relapse-free survival (RFS) and OS in node negative EGFR positive patients (p = 0.03 and p = 0.05 respectively). In a multivariate analysis (Cox proportional hazard model) of all patients, lymph node status was an independent prognostic indicator for OS and RFS (p < 0.00005) and p = 0.00005 respectively), ER status for RFS (p = 0.0006), and EGFR (in the node negative model) for RFS (p = 0.03). When all patients were stratified for EGFR and ER, there was a significant difference in RFS and OS such that EGFR positive and ER negative had the worst prognosis (p = 0.0034 and p = 0.005 respectively).

Adult↗

Tumor angiogenesis in node-negative breast carcinomas--relationship with epidermal growth factor receptor, estrogen receptor, and survival.

Angiogenesis is essential for tumor growth and metastases. Studies in breast carcinomas suggest that microvessel quantitation as a measure of angiogenesis might be one of the most powerful prognostic tools available. Node negative breast cancer is a particular group for which better prognostic markers would be helpful. We therefore measured microvessel density in a series of well characterised node negative breast carcinomas to evaluate angiogenesis as a prognostic marker and assess its relationship to epidermal growth factor receptor (EGFR) and estrogen receptor (ER), which have previously been reported to be of value. 109 patients with a mean age of 55 years and a median follow-up of 25 months were examined. Vessels were immunohistochemically highlighted using an antibody to platelet endothelial cell adhesion molecule CD31, and microvessel density was quantified using a Chalkley point eyepiece graticule. No significant correlation was observed with patient age, tumor size, grade, ER, or EGFR expression. In a univariate analysis of survival, whereas ER expression was not a significant indicator of either relapse-free (RFS) or overall survival (OS), vascular count (VC) predicted both early RFS and OS (p = 0.01) and p = 0.028 respectively). Furthermore, in patients with ER positive tumors, a subgroup usually considered to have a good prognosis, there was a significant reduction in RFS and OS if tumors had high VCs (p = 0.05 and p = 0.002 respectively). A further statistically significant reduction in RFS (p = 0.05) was observed for EGFR positive highly vascular tumors.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Progesterone metabolism by the filamentous fungus Cochliobolus lunatus.

Studies of Cochliobolus lunatus m118 steroid metabolism by thin-layer chromatography, mass spectrometry and NMR spectroscopy revealed that the fungus hydroxylates progesterone at positions 7 alpha, 11 beta and 14 alpha, and oxidizes the 11 beta-hydroxy group to the ketone. The 1H NMR spectra of two of the steroid metabolites, 11 beta,14 alpha-dihydroxyprogesterone and 11-oxo-14 alpha-hydroxyprogesterone, are reported for the first time. It is still not known if all the hydroxylation reactions are performed in C. lunatus by a single, non-specific, steroid hydroxylase, structurally different from the 11 beta-hydroxylase found in higher eucaryotes, or if different forms of the enzyme are involved.

Ascomycota↗