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Biomedical subjects

K Shoji

Publications and source records attributed to K Shoji.

At least 127 records · Page 7Linked to original sources
PubMed1976

Diagnosis and prognosis of early cancer of the colon and rectum.

Diagnostic methods for the cancer of the colon and rectum were compared in two groups of patients, i.e., patients of stage A malignancy in the Dukes classification, and those with the so-called "early cancer of the colon and rectum", and the best way to find cancer of the colon and rectum in its early stage was investigated. At the same time, the prognosis of early cancer of the colon and rectum was studied by the use of the relative survival rate. The following results were obtained. 1) The so-called "early cancer of the colon and rectum", of which invasion was limited to the mucosa and submucosa, can be correctly diagnosed by the combined application of both biopsy and exfoliative cytology under direct vision even before surgery and/or polypectomy. 2) Cancer of the colon and rectum is considered to be a curable disease, if discovered and resected at or before the stage A in the Dukes classification, in which the cancerous proliferation is limited to the wall of the colon and rectum without any metastasis.

Adult↗
PubMed1974

Pleiotropic antibiotic resistance mutations associated with ribosomes and ribosomal subunits in Mycobacterium smegmatis.

Viomycin-resistant strains isolated from Mycobacterium smegmatis demonstrated pleiotropic resistance to tuberactinomycin-N, capreomycin, streptomycin, and kanamycin as a result of mutational alteration of ribosomes, even though they were selected for resistance to a single antibiotic. The pleiotropic drug resistance of three mutants isolated by stepwise selection for resistance to viomycin was due to alteration of the 30S ribosomal subunit. One mutant, strain A, isolated independently by multiple-step selection to viomycin resistance, was resistant to viomycin, tuberactinomycin-N, and capreomycin through an alteration of the 50S ribosomal subunit, whereas it was sensitive to kanamycin but resistant to streptomycin through an alteration of the 30S ribosomal subunit. Three streptomycin-resistant strains, which were isolated by one-step selection at a high concentration of streptomycin, did not show significant co-resistance to any other antibiotics tested in culture and cell-free systems; streptomycin resistance in these mutants was localized on the 30S ribosomal subunit.

Drug Resistance, Bacterial↗
PubMed1972

Analysis of ribosomes from viomycin-sensitive and -resistant strains of Mycobacterium smegmatis.

Viomycin-resistant strains were isolated from Mycobacterium smegmatis. Ribosomes were isolated and tested for drug resistance in subcellular systems containing poly(U) as messenger ribonucleic acid. Resistance to viomycin in these strains was due to altered ribosomes. Further analysis showed that viomycin resistance of two mutants with low level resistance (20 mug/ml) was due to altered 30S ribosomal subunits. Another mutant that was highly resistant to viomycin (1 mg/ml), however, had altered 50S ribosomal subunits.

Bacterial Proteins↗