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Biomedical subjects

K Shimada

Publications and source records attributed to K Shimada.

At least 1,441 records · Page 80Linked to original sources
PubMed1983

Study on subacute toxicity of intravenous sorbitan trioleate (STO) in Wistar rats.

Subacute toxicity of STO was carried out using Wistar rats. STO was administered intravenously at dose levels of 12.5, 50.0 and 200.0 mg/kg for 35 days. No influence on general symptom, body weight, food and water consumption and urinalysis were observed. In 200.0 mg/kg group, the hematological examination revealed anemia corresponding to the histological findings of the bone marrow. Biochemical analysis displayed the significant increase and/or decrease of enzyme values in 200.0 mg/kg group. Morphology showed the swelling, vacuolization and granuloma of the spleen, hepatic granuloma, the increase of reticulum cells and granuloma in the bone marrow. Embolism and thrombus were also found in the pulmonary and tail veins probably due to an artifact caused by the i.v. injection. The toxicity of the STO were observed only in 200.0 mg/kg group of both sexes and any remarkable change other than physical effects were found in other groups under the above dosage. Accordingly, the maximal no-effect level of the STO in Wistar rats was considered to be 50.0 mg/kg.

Animals↗
PubMed1983

[A double blind clinical trial of cefamandole and cefmetazole in complicated urinary tract infections].

We conducted a randomized double blind comparison of cefamandole (CMD) and cefmetazole (CMZ) in the treatment of 193 patients with complicated urinary tract infections. The patients received 1 gram of CMD or CMZ twice a day intravenously by drip infusion over 1 hour for 5 days. Pretreatment urinary leukocyte counts and urinary bacterial counts were at least 5 cells/hpf and 10(4) bacteria/ml, respectively. Each patient was randomly allocated either to CMD or CMZ group. There were 93 patients in CMD group and 100 patients in CMZ group. Clinical efficacy was evaluated based on the effect of treatment on bacteriuria and pyuria according to the criteria set by the UTI Committee, Japan. The response to CMD treatment was excellent in 18 cases (19.4%), moderate in 38 cases (40.9%) and poor in 37 cases (39.8%) with an overall effectiveness of 60.2%, whereas the response to CMZ was excellent in 19 cases (19.0%), moderate in 40 cases (40.0%) and poor in 41 cases (41.0%) with an overall effectiveness of 59.0%. No statistical significant difference was found between 2 treatment groups. Comparison of the bacteriological response between 2 groups showed that the eradication rate for strains of Gram-positive cocci were significantly higher in those patients treated with CMD. Gram-negative rods were eradicated from 68.4% of cases treated with CMD, and 78.0% of those with CMZ, but the difference was not significant. Adverse reactions were observed in 3 patients receiving CMD 1 case each of diarrhea, eruption and epigastric pain. Abnormality in laboratory tests was found in 6 patients in each treatment group. The results indicate that CMD is effective, safe and useful in the treatment of patients with complicated urinary tract infections, and its efficacy, safety and usefulness are comparable with those of CMZ.

Adolescent↗
PubMed1983

[Ureteral polyp in childhood: a case report].

An 8-year-old boy was admitted because of left flank pain. The excretory urogram showed left hydronephrosis and a filling defect at the pelviureteric junction. Surgical exploration revealed a polypoid lesion on the mucous membrane of the pelviureteric junction and ureteric stenosis due to a periureteric fibrous band. Dis-membered pyeloplasty was performed. The pathological diagnosis was benign fibrous polyp of the ureter. Convalescence was uneventful and an intravenous pyelogram showed no evidence of recurrence one year after operation. We found 13 cases of ureteral polyps in children in the Japanese literature. The differences between ureteral polyps in childhood and those in adults are discussed.

Age Factors↗
PubMed1983

[Scrotoplasty for repair of prepenile scrotum].

Our surgical technique of scrotoplasty for repair of prepenile scrotum performed at our Department is described. Inverted omega skin incision was made around the scrotal skin and base of the penis. Scrotal flaps were prepared and these were brought beneath the penis. These scrotal flaps were sutured in two layers, subcutaneous tissue with 3-0 or 2-0 chromic catgut and skin with 4-0 or 3-0 prolene. Twenty four patients with prepenile scrotum were operated on with this technique and cosmetic results were excellent. When complicated with hypospadias, scrotoplasty was performed as the third stage operation, following chordectomy and urethroplasty.

Adolescent↗
PubMed1983

[Clinical statistics on outpatients, inpatients and operations at the Department of Urology, Hyogo College of Medicine, in 1982].

Statistical studies on 2,040 new outpatients, 575 inpatients and 570 operative procedures at our department in 1982 revealed the following. The most frequent diseases among the outpatients were urogenital infections followed by anomalies and tumors. Over half of the inpatients were pediatric patients and the major diseases among inpatients were hypospadias, vesicoureteral reflux, urolithiasis, congenital urethral stenosis and undescended testis. A total of 570 operations were performed on 531 patients, and the major five operations were hypospadias repair (79), optic internal urethrotomy (71), TUR-P (49), ureterocystoneostomy (33) and orchidopexy (32).

Adolescent↗
PubMed1983

[Clinical investigation of intratumoral OK-432 administration].

The clinical effect of intratumoral administration of OK-432 was evaluated. The patients with nonresectable advanced cancer were divided into three groups according to administration method of OK-432 at laparotomy: Group I; Intratumoral administration, Group II; Scattering to the abdominal cavity, and Group III; No OK-432, administration. Improvement in suppression of tumor progression was more frequently noticed in the Group I compared to the Group II and III, but there was no significant difference in terms of survival time and rate among the three groups.

Adenocarcinoma↗
PubMed1983

[Current status and problems of gastric cancer in the aged].

Based on our analysis of 1) gastric cancer patients surgically treated between 1972-1980 in Niigata Prefecture, 2) mortality statistics, and 3) 381 gastric cancer patients older than 70 years operated in our hospital, we concluded that 1) The number of geriatric surgical patients with gastric cancer, especially early gastric cancer, is on the increase in Niigata Prefecture. 2) The mortality from gastric cancer has decreased markedly in 70-74 year-old patients, has declined slightly in patient ranging from 75-79 years and has increased in patients over 80 years. 3) In patients between 75-79 years and 70-74 years, surgery as almost equally safe and their long-term survival rate was similar. Our results suggest that gastric cancer patients ranging between 75-79 years should be operated as radically as younger patients.

Aged↗