[Animal experiments on ileus of the large intestine with special reference to large bowel motility].
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
K Schweizer
Publications and source records attributed to K Schweizer.
[Significance of the immune resistance for the oncolytic effect of clostridia].
Explore the source record for details and available documents.
Animals↗
Recombinant human granulocyte colony-stimulating factor does not influence distribution or sister chromatid exchange frequency of proliferating mononuclear cells of the peripheral blood.
Phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMC) were treated with increasing concentrations of filgrastim, the unglycosylated methionine granulocyte colony-stimulating factor of man (rhG-CSF), and cultured for 72 h. There were no impaired proliferation or differentiation of proliferating PBMC, no impaired expression of activation markers such as the low-affinity interleukin 2 receptor and transferrin receptor, and no induction of sister chromatid exchanges. Under these conditions, no effects of a general DNA destabilization of peripheral blood leukocytes was observed. Thus, longterm administration of therapeutical concentrations of rhG-CSF should not produce severe mutagenic effects.
Adult↗
Indication of a certain molecular correlation between rat IgE and human IgE.
The PCA-activity of rat sera sensitized with Ascaris suum antigen can be absorbed by antihuman IgE and by rabbit or sheep antihuman IgE convalently bound to sephadex particles or paper discs respectively. In vitro, rat immune sera show positive results using the human RIST-system abolished by preheating for 2 hours at 56 degrees C and therefore excluding an interaction of IgG 4. In contrast, no rat sera activity was seen using the human PRIST-system. These results agree with the concept of a single common antigenic determinant in human and rat IgE since in the human RIST and PRIST-system the binding of rat IgE to antihuman IgE could only be demonstrated on the principle of competitive inhibition (RIST) but not on that of a sequential binding (PRIST). The possibility of a certain heterogeneity in the IgE population can not be excluded.
Animals↗