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K Schmitz

Publications and source records attributed to K Schmitz.

57 records · Page 4Linked to original sources

Correlates of changes in leisure time physical activity over 2 years: the Healthy Worker Project.

BACKGROUND: This study is the first to examine associations between concurrent changes in demongraphics, health behaviors, and physical activity in a free-living cohort of adults. METHODS: Surveys were conducted at 32 worksites (n = 3,672 workers) before and after a 2-year health promotion intervention. Associations between concurrent changes in sociodemographics, health, health behaviors, and physical activity were examined. Characteristics of individuals were also examined in four extreme physical activity change groupings: consistently very active, consistently very inactive, and changing from one extreme to the other over time. RESULTS: Among women, being married was associated with consistently low levels of physical activity, and increases in education were associated with increases in physical activity. Among both men and women, maintenance of single marital status was associated with increased physical activity levels, and increases in BMI were associated with decreases in physical activity. Increases in high-fat/calorie food intake were associated with increases in physical activity among men, but not among women. CONCLUSION: The observed associations indicate factors that may be important for understanding decreases in physical activity. The dynamic associations between changes in sociodemographics and physical activity demonstrate the need to examine changes in sociodemographics over time, rather than at only a single time point.

Adult↗

Expression of mucin-associated carbohydrate core antigens in esophageal squamous cell carcinomas.

In contrast to gastrointestinal cancer, where a correlation between the expression of different mucin-associated core antigens with clinico-pathological parameters and survival probability, has been established, little is known about their importance in esophageal cancer. Therefore, we characterized esophageal squamous cell carcinomas from 84 patients immunohistochemically by applying monoclonal antibodies (mabs) directed against the Thomsen-Friedenreich (TF) antigen MUC1-bound TF antigen and sialyl-Tn. TF was observed in about 40% of the cases and MUC1-TF epitope in about 75%. Sialyl-Tn was detectable in about half of the carcinomas under study. None of these mabs showed any correlation between binding pattern and clinico-pathological variables, such as TNM stage, lymph node metastasis or grading. However, a strong expression of MUC1-TF epitope as well as sialyl-Tn antigen predicted a poor survival probability. In conclusion, it is suggested that mucin-associated carbohydrate core antigens are involved in the biology and clinical course of esophageal squamous carcinomas.

Adult↗