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Biomedical subjects

K Sawada

Publications and source records attributed to K Sawada.

At least 415 records · Page 23Linked to original sources
PubMed1980

Analysis of sera from patients with breast cancer for blocking and induction of leukocyte adherence inhibition.

The correlation of serum capacity for blocking and arming with effector cell reactivity has been examined in patients with breast cancer by using the leukocyte adherence inhibition (LAI) assay. It was found that sera from breast cancer patients possessed the ability to make nonimmune mononuclear cells specifically reactive (i.e., armed) to the breast cancer extract and to specifically block the reactivity of mononuclear cells from breast cancer patients with the cancer extract. Sera from patients with breast cancer whose mononuclear cells were nonreactive to the corresponding tumor extract (6/8) showed higher blocking than sera from patients whose cells showed reactivity to the corresponding tumor extract (3/13). Similarly, sera from patients with positive LAI response (6/13) induced arming of normal mononuclear cells more often than sera from patients with negative LAI (2/8). There also appeared to be an inverse correlation between the capacities of serum from breast cancer patients to exhibit blocking and arming. That is, serum arming activity was found only in sera which showed no blocking, and serum blocking activity was detected only in sera without arming, activity, except for one sample. The possibility is discussed that immune complexes play a key role in both serum activities, and that their biphasic character might be dependent on the ratio of antigen of antibody.

Antigen-Antibody Complex↗
PubMed1979

Effect of the autonomic blockade on the automaticity of the A-V junctional pacemaker in awake dogs.

The effect of the autonomic blockade on the automaticity of the A-V junctional pacemaker was evaluated in 15 awake dogs with experimentally induced A-V junctional rhythm. The duration of asystole after overdrive (D.A.O.) in these dogs was prolonged significantly in accordance with increase in the drive rate, and the mean +/- SD of the D.A.O. reached 4.7 +/- 1.1 seconds (N = 15) after overdrive at 2.5 times the spontaneous heart rate. After administration of atropine (0.4 mg/kg; i.v.) to eight dogs, the mean +/- SD of the D.A.O. at the same rate decreased from 4.5 +/- 0.9 to 3.4 +/- 1.2 seconds. After administration of practolol (0.5 mg/kg; i.v.) to the seven other dogs, the mean +/- SD of the D.A.O. at the same rate increased remarkably from 4.9 +/- 1.3 to 9.4 +/- 3.0 seconds. Intravenous injection of practolol (0.5 mg/kg) had no effect upon the D.A.O. in the five dogs with sinus rhythm. Thus, it is suggested that (1) the sympathetic nerve might play a more important role in regulating the automaticity of the A-V junctional pacemaker than the vagus and (2) it physiologically might take over 5.0 seconds for the A-V junctional pacemaker to initiate an escape beat during longstanding sinus arrest, if a marked dysfunction of the A-V junctional pacemaker occurs due to a decrease in tension of the sympathetic nerve.

Animals↗
PubMed1979

Prolonged injection angiography for diagnosing intracranial cavernous hemangiomas.

A case of intracranial cavernous hemangioma displaying feeding arteries, tumor stains, and venous pools is presented. Tumors of this type may simulate avascular masses on angiography; however, when surgically excised, they bleed profusely. A correct preoperative diagnosis can help avoid unnecessary incisions. Prolonged injection angiography clearly depicts the tumors and their venous pools, which may be pathognomonic of cavernous hemangiomas.

Adult↗