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Biomedical subjects

K Sawada

Publications and source records attributed to K Sawada.

At least 397 records · Page 22Linked to original sources
PubMed1981

Granular cell myoblastoma of the bronchus in a child: a case report.

Granular cell myoblastoma of of the right main bronchus in a 5-year-old girl is reported. The tumor extended to the lower trachea from the right main bronchus which was occluded completely by the tumor. The diagnosis was established histologically by a obtaining bronchoscopic biopsy specimen. Right pneumonectomy was carried out to control pulmonary suppuration caused by the tumor obstruction of the bronchus. External radiotherapy and interstitial brachytherapy were successful to control the growth of the residual tumor. She has been free from symptoms for about 12 years after the treatment.

Bronchial Neoplasms↗
PubMed1981

Cyst of the conus medullaris manifesting amyotrophic lateral sclerosis syndrome.

An intramedullary cyst of the conus medullaris was found in a 49-year-old man, who presented progressive amyotrophy in the lower extremities, without root pain or sensory impairment. The clinical manifestation resembled that of ALS, although there were some atypical features, such as urinary difficulty and atrophy in the lower limbs. Myelography demonstrated an intradural oval mass and a laminectomy revealed a cystic malformation of the conus medullaris. Drainage of the cyst resulted in a marked clinical improvement.

Amyotrophic Lateral Sclerosis↗
PubMed1981

[A huge frontal sinus pyocele extending into the cerebral falx - a case report (author's transl)].

A 50-year-old male was admitted to us presenting a bulging of 5 X 6 cm in size on the forehead. His general condition was excellent and neurological status was normal. The mass in the forehead was soft and showed a fluctuation. On the plain skull films, a lobulated bone defect of 5 X 4 cm in size was noticed in the frontal bone and the frontal sinus completely disappeared. Carotid angiograms revealed posterior displacement of the supraclinoid portion of the internal carotid arteries and the proximal part of the anterior cerebral arteries, and elevation and posterior displacement of both frontopolar arteries. Capillary and venous phase of the carotid angiograms demonstrated an avascular area in the frontal cranial fossa. Branches of the anterior cerebral artery were stretched and displace surrounding the avascular mass. These angiographic findings indicated a huge avascular both frontal lobes posterolaterally. CT scanning revealed a large isodensity mass and the periphery of the mass was enhanced in a ring-like fashion with contrast medium. The mass protruded as a subcutaneous mass through the defect of the frontal bone. The content of the mass was surgically evacuated. The mass was a pyocele containing thick yellowish purulent fluid. It arose from the frontal sinus and extended into the anterior cranial fossa through the destroyed posterior wall of the sinus to separate the falx into two leaves of the dura mater and displace both frontal lobes laterally and posteriorly. Extension of the frontal sinus mucocele and pyocele to the anterior cranial fossa was discussed.

Cerebral Angiography↗
PubMed1981

[Three cases of cystic neurinoma arising from the upper cervical nerve roots and extending into the posterior cranial fossa (author's transl)].

Three cases of cystic neurinoma arising from the upper cervical spinal nerve roots and extending to the posterior cranial fossa through the foramen magnum were reported. Case 1 was a 52-year-old female presenting marked bilateral papilledema, hyperactive right knee jerk, left positive Gordon reflex and trunkal ataxia. The mass was mostly cystic and arose from the left 1st cervical nerve root. It extended to the posterior fossa, occupied the cerebello-medullary cistern and displaced the left cerebellar hemisphere posteriorly and superiorly. Case 2 was a 39-year-old male presenting marked bilateral papilledema, neck stiffness, dysfunction of the right 7, 9, 10 and 11th cranial nerves, gaze nystagmus, Horner's syndrome, right limb ataxia, and ataxic gait. The mass was totally cystic containing yellowish fluid and was growing from the right 2nd cervical spinal nerve root. The mass extended to the posterior cranial fossa up to the right cerebello-pontine angle and compressed the medulla oblongata, upper cervical cord and 7th through 11th cranial nerves on the right side. Case 3 was a 66-year-old male presenting marked bilateral papilledema, gaze nystagmus, left hemiparesis, bilateral hyperactive deep tendon reflexes, numbness of the left fingers and ataxic gait. CT scanning revealed in the midline of the posterior cranial fossa a low density mass which was enhanced in a ring-like fashion. Vertebral angiograms showed an avascular mass displacing the PICAs upwards and elongating its cranial loops antero-posteriorly. The mass was totally cystic, arose from the left 2nd cervical spinal nerve root, extended to the posterior cranial fossa and occupied the cisterna magna and vallecula. Foramen magnum syndrome was discussed and the symptoms and signs presented in these three cases were compared with those presented by foramen magnum meningioma in other reports.

Adult↗
PubMed1980

Changes in sensitivity to histamine of guinea pig cardiac muscles during postnatal development.

Histamine stimulates the heart by interacting with cardiac histamine receptors. We investigated the postnatal changes in histamine sensitivity with spontaneously beating right atria and electrically driven left atria and right ventricular papillary muscles from 0-, 5-, and 10-day-old and adult guinea pigs. The positive chronotropic response to histamine in right atria was antagonized by cimetidine but not by chlorpheniramine at any age. Chlorpheniramine did not antagonize the positive inotropic effect of histamine and 2-(2-pyridyl)ethylamine in the immature left atria but it blocked the positive inotropic effect in the adult; cimetidine had no effect. The positive inotropic effect of histamine in right ventricular muscles was not affected by chlorpheniramine in immature right ventricular muscles but was antagonized in the adult. These results suggest that, in immature left atria and right ventricular muscles, there is no H1-receptor system mediating the positive inotropic effect of histamine and that, as age advances, this system begins to mediate the positive inotropic effect. In immature left atria, non-H1 and non-H2 receptors exist and mediate the positive inotropic effect of histamine.

Animals↗