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Biomedical subjects

K Satoh

Publications and source records attributed to K Satoh.

At least 1,189 records · Page 66Linked to original sources
PubMed1981

Augmented malondialdehyde production by platelets from patients with cerebrovascular disorders.

A basic study was conducted on the method for the determination of thiobarbituric acid-reactive substances (TBARS) produced by platelets. Some modifications were introduced which enabled a precise semimicrodetermination. The average values of platelet TBARS production in hypertensives and in patients with cerebral infarction were higher than that in healthy controls. Among patients with cerebral infarction, those with angiographically demonstrated obstruction of internal carotid or middle cerebral arteries showed an increased production as compared with non-obstructive cases, these results may suggest the important role of platelet arachidonate metabolism in obstructive cerebrovascular disorders.

Aged↗
PubMed1981

Chemical and biological properties of subfractions of hot-water extract from delipidated BCG.

a hog-water extract from delipidated Mycobacterium bovis strains BCG was fractionated by precipitation with ethanol. The chemical and biological properties of the subfractions thus obtained were investigated. A subfraction precipitated at 20% ethanol contained less neutral sugar and more ninhydrin-positive substance than other subfractions. Only the guinea pigs that were treated with 20% ethanol-precipitate showed no humoral antibody response to egg white albumin, despite positive skin reaction. The subfractions precipitated at low concentrations of ethanol exhibited a significant antitumor activity in ddY and C3H He mice inoculated intraperitoneally with tumor cells. These results suggest that the hot-water extract from delipidated BCG consists of subfractions with different chemical and biological properties.

Adjuvants, Immunologic↗
PubMed1981

Characterization of cardiovascular actions of CS-611, a new coronary dilator, in the dog.

In anesthetized, open-chest dogs 8-tert.-butyl-7,8-dihydro-5-methyl-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine (CS-611), in doses of 0.1--1 mg/kg i.v. decreased systemic blood pressure, coronary resistance and arterio-venous O2 difference and increased coronary sinus outflow in a dose-related manner, but myocardial oxygen consumption was virtually unchanged. At 0.3 mg/kg i.v. of the drug, coronary sinus outflow was doubled, but heart rate and AV conduction time were not changed. In canine isolated, blood-perfused heart preparations, CS-611 only in large intra-arterial doses produced the following responses; a decrease in sinus rate followed by a slight increase in the SA node preparation, a transient prolongation of AV conduction time followed by a slight shortening in the AV node preparation and a transient decrease followed by a sizable increase in developed tension in the papillary muscle preparation. The drug in large intra-arterial doses decreased the rate of automaticity of the papillary muscle preparation. From these results CS-611 can be characterized as a coronary dilator virtually devoid of cardiac actions in doses sufficiently increasing coronary blood flow. By comparison of the present results with those of previous results on other coronary dilators it was revealed that CS-611 may have a novel mechanism of action.

Animals↗
PubMed1981

Effects of trapidil on musculature and vasculature of the dog trachea in situ.

In anesthetized dogs the trachea in situ was perfused with blood through the cannulated cranial thyroid arteries. The effects of trapidil on tracheal musculature and vasculature were assessed in comparison with those of isoproterenol and theophylline. All drugs were injected intra-arterially. Isoproterenol (0.03--0.3 microgram), trapidil (10--300 micrograms) and theophylline (30--300 micrograms) all produced an increase in tracheal blood flow (tracheal vasodilatation) and a decrease in the tracheal intraluminal pressure elevated by neostigmine (tracheal dilatation). In high doses the three drugs all produced maximal tracheal dilatation. Dose-response curves for tracheal vasodilatation to the three drugs were all parallel together, and trapidil was about 2700 time less potent than isoproterenol and about 3 times more potent than theophylline on a weight basis in producing tracheal vasodilatation. Dose-response curves for tracheal dilatation to the three drugs were also parallel together, and trapidil was about 880 times less potent than isoproterenol and about 3 times more potent than theophylline on a weight basis. When compared with isoproterenol, trapidil was about 3 times more effective on tracheal musculature than on tracheal vasculature, and theophylline resembled trapidil. The results suggest that trapidil can also be used as a bronchodilator.

Animals↗
PubMed1980

Prostaglandin F2 alpha metabolites in plasma and urine during pseudopregnancy in the rabbit.

Two prostaglandin (PG) F2 alpha metabolites, 13,14-dihydro-15-keto PGF2 alpha (dhkPGF2 alpha) in blood and 5 alpha, 7 alpha-dihydroxy-11-keto tetranorprostane 1,16-dioic acid (PGF2 alpha UM) in urine, were measured in the pseudopregnant rabbit by radioimmunoassay. During pseudopregnancy, marked increases in the two PGF2 alpha metabolites were demonstrated at about the time of luteal regression. Hysterectomy and intrauterine administration of indomethacin prolonged the life span of corpora lutea in the pseudopregnant rabbit by 8 and 5 days, respectively, with no elevation of PGF2 alpha UM excretion. The findings indicate that PGF2 alpha is a uterine luteolysin in the pseudopregnant rabbit, as in other animal species.

Animals↗
PubMed1980

Studies on the purification and characterization of human urinary plasminogen and plasmin.

A new method is described for the preparation of highly purified human plasminogen and plasmin with specific activity of 32 CTA units per mg of protein. With this method, the purification of the urinary plasminogen + plasmin antigenic materials from patients with chronic glomerulonephritis, disseminated intravascular coagulation syndrome and severe toxemia of pregnancy was performed, and the resulting highly purified proenzyme and enzyme were analyzed by immunoelectrophoresis, separative agar electrophoresis, gel filtration and SDS-gel electrophoresis. Our findings indicated that urinary plasmin reflects more closely the extent of intraglomerular fibrinolysis, while urinary plasminogen reflects non-selective proteinuria in patients with chronic glomerulonephritis or severe toxemia of pregnancy.

Animals↗
PubMed1980

Fine structure of noradrenaline nerve terminals in the dorsomedial portion of the nucleus tractus solitarii as demonstrated by a modified potassium permanganate method.

Fine structure of the noradrenaline (NA) nerve terminals in the dorsomedial portion of the nucleus tractus solitarii (NTS) was investigated by glyoxylic acid-potassium permanganate fixation method. The NA nerve terminals in this area contained a large number of small cored vesicles (SCV) (about 400-600 A in diameter) together with a few large cored vesicles (LCV) (about 1000 A in diameter). The most frequent feature of NA nerve terminals observed in this area was axo-dendritic contact. An axo-axonic contact between NA and non-NA terminals was also occasionally identified, while no axo-somatic contact was found in this area as far as examined. At the contact zone between NA terminals and other neuronal elements, the following profiles suggestive of synapse-like contact were identified: 1) somewhat dense material between contact membranes (intersynaptic filaments); 2) a slight accumulation of dense material adjacent to postcontact membranes; 3) disarrangement of contact membranes and enlargement of the space between these membranes; 4) aggregation of SCV and LCV to contact membranes. Finally it should be emphasized that NA nerve terminals often made a neuronal cluster or rosette with other neuronal elements, suggestive of a complicated role of NA on NTS function.

Animals↗
PubMed1980

Coronary vasodilator and cardiac effects of optical isomers of verapamil in the dog.

Coronary vasodilator and cardiac effects of (-) and (+) verapamil were investigated in two kinds of canine heart preparations. When administered intravenously to anesthetized open-chest dogs, (-) verapamil was only 1.5-2 times as potent as (+) verapamil in increasing coronary sinus outflow and in decreasing mean arterial pressure and coronary resistance. However, (-) verapamil was about 5 times as potent in producing a negative chronotropic effect, about 10 times as potent in producing a negative dromotropic effect, and about 15 times as potent in decreasing myocardial oxygen consumption as (+) verapamil. When injected into the anterior septal artery in the isolated, blood-perfused papillary muscle preparation of the dog. (-) verapamil was about 15 times as potent as (+) verapamil in producing a negative inotropic effect. However, in increasing blood flow through the anterior septal artery (-) verapamil was only about 2.5 times as potent as (+) verapamil. These results indicate that in equieffective doses in producing coronary vasodilatation (+) verapamil is far less cardiodepressant than the (-) isomer.

Animals↗