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Biomedical subjects

K Satake

Publications and source records attributed to K Satake.

At least 145 records · Page 8Linked to original sources
PubMed1986

Pyloric stenosis: an unusual complication of Behçet's disease.

A 20-yr-old Japanese man with longstanding Behçet's disease had pyloric stenosis and multiple duodenal ulcers. The pyloric stenosis was due to edematous hypertrophy of the pyloric ring and was unrelated to duodenal ulceration. The evidence suggests that the pyloric stenosis and multiple duodenal ulceration were a manifestation of Behçet's syndrome and not merely incidental peptic ulcer disease.

Adult↗
PubMed1986

Postprandial plasma cholecystokinin response in patients after gastrectomy and pancreatoduodenectomy.

Endogenous cholecystokinin release after a test meal was measured in the controls, patients with Billroth I and II anastomosis after subtotal gastrectomy, patients with a Roux-en-Y anastomosis after total gastrectomy, and patients with a modified Child's reconstruction after pancreatoduodenectomy 2 months after surgery. The postprandial plasma level in patients with Billroth I and II anastomosis was close to that in the controls. In a Roux-en-Y anastomosis, this level was slightly higher than in the controls and patients with a Billroth anastomosis. Differences in integrated cholecystokinin secretion at 120 min in different groups were insignificant. After a modified Child's reconstruction, the postprandial level was significantly lower than in the controls and in patients with a Billroth II anastomosis. One patient with a modified Child's reconstruction was examined 8 yr after surgery, and she had a normal response. We suggest that either the duodenum or jejunum used for gastrointestinal anastomosis can release cholecystokinin normally, and pancreatoduodenectomy may decrease cholecystokinin release 2 months after surgery.

Aged↗
PubMed1986

[Measurement of pancreatic microcirculation using hydrogen gas generated by electrolysis in dogs].

Measurements of pancreatic microflow were investigated using hydrogen gas generated by electrolysis in dog. After laparatomy under general anesthesia, uncinate process of the pancreas was punctured by a needle electrode for electrolysis and determination of hydrogen gas. The consecutive measurements of pancreatic microflow revealed the good reproducibility at the same point of the pancreas. The simultaneous measurements of pancreatic microflow by electrolysis and pancreatic tissue blood flow by H2 inhalation method were carried out at the same point of the pancreas. Correlation analysis of both measurements revealed coefficient of 0.751 and a significant relationship was observed (p less than 0.05). However, the value was a little higher in pancreatic microflow as compared with pancreatic tissue blood flow. Pancreatic microflow and pancreatic exocrine secretion increased after intravenous administration of Dopamine and Secretin (10 micrograms/kg/min). It is concluded that the measurement of pancreatic microflow by hydrogen gas generated by electrolysis is a useful method on understanding the microcirculation of the pancreas.

Alprostadil↗
PubMed1985

A clinical evaluation of carbohydrate antigen 19-9 and carcinoembryonic antigen in patients with pancreatic carcinoma.

We have studied serum carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) in 221 persons to assess their usefulness in the diagnosis of pancreatic carcinoma. Although serum CA 19-9 and CEA in all healthy controls were within normal limits, the positive ratings of serum CA 19-9 and CEA in all benign disease were 9.8% and 18.1%, respectively. Sensitivity of serum CA 19-9 for pancreatic carcinoma was 70.5%, which was higher than that found in healthy controls, benign disease, and other malignant disease except biliary carcinoma; but sensitivity of serum CEA levels (67.7%) was not different from that seen in malignant disease. Three of 34 patients (8.8%) with pancreatic carcinoma who had a above-normal levels of serum CA 19-9 but not serum CEA were resectable. Although there was no correlation between serum CA 19-9 and CEA, advanced stages of pancreatic, gastric, and colorectal carcinoma tend to show high serum CA 19-9 and CEA, but no statistical differences were observed in relation to the stages of these carcinomas. Comparative studies of serum CA 19-9 and CEA for sensitivity and the predictive value of true positive and negative results for detecting pancreatic, gastric, and colorectal carcinoma showed that serum CA 19-9 has significantly higher sensitivity and predictive value of true positive results for pancreatic carcinoma than for gastric and colorectal carcinoma (P less than 0.05). However, serum CEA measurements did not show any difference between these carcinomas, and the highest predictive value of a true negative result for excluding pancreatic carcinoma was also observed in serum CA 19-9. These results indicate that although the CA 19-9 assay is not specific for pancreatic carcinoma, it is more useful adjunct method for diagnosing pancreatic carcinoma, possibly in resectable stages.

Adult↗
PubMed1985

Comparative studies of plasma secretin response after reconstructive surgery of the stomach and pancreas.

The postprandial plasma secretin response was examined in ten normal persons, seven patients with a Billroth I and seven with a Billroth II anastomosis after subtotal gastrectomy, seven with a Roux-en-Y anastomosis, two with an interposed jejunal anastomosis, and five with a modified Child's anastomosis after pancreatoduodenectomy. The postprandial plasma secretin response in patients with Billroth I anastomosis was better than that in patients with a Billroth II anastomosis but was less than that of normal subjects. Although no postprandial secretin response was noted in Roux-en-Y anastomosis after total gastrectomy, a response was seen in patients with the interposed jejunal anastomosis because the digested food passed through the duodenum, but it was less than that for Billroth I and II patients and normal controls. After a modified Child's reconstruction, the postprandial secretin response was similar to that of patients with the Billroth II, which preserved the duodenum. A patient with a modified Child's reconstruction was examined 12 years after surgery and had the same response as other patients with the modified Child's reconstruction and those with a Billroth II anastomosis within 2 months after surgery. After ingestion of hydrochloride solution, the plasma secretin release in patients with a Billroth I and II anastomosis after subtotal gastrectomy and Roux-en-Y anastomosis after total gastrectomy had a better response than after a meal, but this was less than in normal subjects. The authors suggest that careful selection of intestine for the gastrointestinal anastomosis, which contains many secretin secretory cells, is important to obtain endogenous secretin release. For gastrojejunostomy after pancreatoduodenectomy, a method preserving the pylorus is better than the usual gastrojejunostomy because it maintains gastric acid. The ingestion of secretin stimulants, such as hydrochloride, may help to prevent pancreatic dysfunction after gastrectomy and other surgical reconstructions.

Duodenum↗
PubMed1985

Toxic products in hemorrhagic ascitic fluid generated during experimental acute hemorrhagic pancreatitis in dogs and a treatment which reduces their effect.

Toxic substances produced in hemorrhagic ascitic fluid during experimental hemorrhagic pancreatitis in dogs were investigated. An average of 394 ml of ascitic fluid was produced within 5 h after the induction of acute pancreatitis by intraductal injection of a mixture of autologous bile and trypsin. Hemorrhagic ascitic fluid was collected under sterile conditions, which was confirmed by aerobic and anaerobic culture and a Limulus test. The sterile fluid was injected intraperitoneally into mice in doses of 2 and 3 ml, and the mortality rate 72 h after injection was 66.0 and 88.4%, respectively. It contained high concentrations of pancreatic enzymes, including trypsin and esterase activity, as well as bradykinin, histamine and prostaglandin. Autopsy and histological examination of mice revealed shock with lung damage. The results suggest that hemorrhagic ascitic fluid produced in pancreatitis may be an important factor for early deaths in acute pancreatitis. When a new synthetic antiprotease (nafamstat mesilate) in a dosage of 0.2 mg was mixed with 1 ml of ascitic fluid, trypsin was not detectable, and bradykinin was reduced 1.0 ng/ml from 8.0 ng/ml, while esterase activity decreased to one tenth of its previous activity. The mortality following injection of the solution decreased to 26.7 and 80.6%, respectively. These results indicate that peritoneal lavage with a solution containing antiprotease may be an effective treatment for hemorrhagic acute pancreatitis.

Acute Disease↗
PubMed1985

Evaluation of serum pancreatic enzymes, carbohydrate antigen 19-9, and carcinoembryonic antigen in various pancreatic diseases.

Comparative studies of pancreatic enzymes carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) were performed in various pancreatic disease. In acute pancreatitis as well as during acute exacerbation of chronic pancreatitis, all pancreatic enzymes were abnormally high. In chronic pancreatitis, they did not have any diagnostic sensitivity for pancreatic insufficiency. In pancreatic carcinoma, serum elastase levels may have a diagnostic value compared with other pancreatic enzymes. In studies of CEA and CA 19-9, both tumor markers were within normal range in benign pancreatitis but 27.7% of CEA and 30.7% of CA 19-9 in acute pancreatitis were above normal. In pancreatic carcinoma, although most of these patients had advanced disease, both tumor markers were extremely high and 61% for CEA and 71% for CA 19-9 were above normal. In patients with resected pancreatic carcinoma, serum CEA was slightly higher than normal CA 19-9 was much higher than normal. The sensitivity of CEA and CA 19-9 in this group were 33 and 77.7%, respectively. The results indicate that the CA 19-9 assay is a useful adjunct in the diagnosis of pancreatic carcinoma, possibly in the resectable stage especially combined measurement of serum elastase and CEA.

Adolescent↗
PubMed1985

A large retroperitoneal encapsulation of bile from a spontaneous perforation of the common bile duct.

We report a patient with spontaneous rupture of the common bile duct. This is an extremely rare condition which produces free leakage of bile into the peritoneal cavity. There has been no previous report concerning the formation of a large retroperitoneal encapsulation of bile. The preoperative diagnosis in our patient was very difficult and endoscopic retrograde pancreatocholangiography and cystography by ultrasound guidance were helpful.

Aged↗
PubMed1985

Electron microscopic studies of human pancreatic adenocarcinoma.

Tissue samples from 12 patients with pancreatic carcinoma were studied by light and electron microscopy. Ten were diagnosed as adenocarcinoma by light microscopy. However, three different electron microscopic findings were observed among these ten adenocarcinomas. One showed that the tumour cells had large nuclei with poorly developed intracellular organelles. Many mucinous granules, well developed cellular projections and intracellular microcysts were observed. In the second findings were different in that these cells had no granules. The intracellular organelles were developed poorly and abundant microvilli and cellular projections were observed. These observations suggest that the tumour cells may arise from pancreatic ductular cells. The third specimen showed a completely different appearance. There were pleomorphic nuclei with enlarged nucleoli and the cytoplasm contained swollen mitochondria, a well developed rough endoplasmic reticulum and varying numbers of zymogen-like granules. Occasionally, the zymogen-like granules were absent. These characteristics resemble the de-differentiation of acinar cells which has been repeated in experimental pancreatic carcinoma. These results suggest that careful examination of human pancreatic carcinoma may show more cells of acinar origin.

Adenocarcinoma↗
PubMed1985

[Postprandial plasma secretin response in various types of reconstructive surgery of the stomach and pancreas].

The postprandial plasma secretin concentrations were investigated in patients with Billroth I, Billroth II, Roux-en Y and jejunal interposition following gastrectomy or modified Child's reconstruction after pancreatoduodenectomy. In patients with Billroth I anastomosis the postprandial plasma secretin response was not so high as that for normal volunteers, however it was much better compared with Billroth II anastomosis and Roux-en Y anastomosis after total gastrectomy. In an interposed jejunal anastomosis after total gastrectomy the plasma secretin increased at 20 minutes in postprandial state, even though there was not clear postprandial response of plasma secretin in patients with Roux-en Y anastomosis. Following the modified Child's method after pancreatoduodenectomy the postprandial plasma secretin response was similar to that of Billroth II anastomosis. Following acid load plasma secretin response was much higher than that of postprandial state in patients with Billroth-I, Billroth-II and Roux-Y anastomosis after gastrectomy. The results indicate that acid is important in stimulating secretin release and also the passage of food through the duodenum is important for the release of secretin.

Duodenum↗
PubMed1985

[Pathophysiology and treatment of severe pancreatitis].

The current study was designed to characterize toxic substances in hemorrhagic ascitic fluid by using in vivo dogs model and to examine the toxicity of hemorrhagic ascitic fluid by using an in vivo mice model injecting the fluid intraperitoneally. Our experiment showed that high levels of bradykinin, histamine and prostaglandin E were found in serum and in hemorrhagic ascitic fluid which reported as toxic substances during severe pancreatitis. A similar finding was also obtained clinically in four patients with severe acute pancreatitis. The mortality rate on 72 hours following the intraperitoneal injection of 2.0 and 3.0 ml of ascitic fluid were 66.0% and 89.7% respectively. Mice which died following the injection of ascitic fluid showed shock lung at autopsy. These results indicate that peritoneal lavage might be an effective method for the treatment of severe pancreatitis. We evaluated 25 patients with severe acute pancreatitis clinically. Laparotomy and drainage operations were performed in 16 patients of these patients. Twelve among 16 patient had good results. The cause of death were multiorgan failures.

Acute Disease↗
PubMed1984

Copper complexes at N- and C-site of ovotransferrin: quantitative determination and visible absorption spectrum of each complex.

Copper complexes at the two sites of ovotransferrin (TF) differed markedly in the rate of Cu release by EDTA. During the reaction, lambda max of the remaining Cu-Tf complex shifted to red side, while the difference spectrum of FenCu2-nTf vs. FenTf in which the N-site had been preferentially occupied with Fe had lambda max at blue side from that of Cu2Tf, 440 nm. From these results, the intrinsic spectrum for Cu-complex at each site was assigned: lambda max 450 nm for N- and 430 nm for C-site. The differences in the release rate and the spectrum can be used for the identification of the two domains of Tf and for the analysis of metal-binding behavior of each site.

Animals↗
PubMed1984

Selective modification of myosin SH1 with 1,2,4-trinitrobenzene. VIII. Thiols of myosin.

Myosin has 2 mol of the most reactive thiol, named SH1. 1,2,4-Trinitrobenzene (TNB), a novel dinitrophenyl(DNP)ating reagent [Takahashi et al. (1983) Chem. Lett. 1445-1448], was found to react only with SH1 without any other amino acid residues in myosin under the conditions used. Its reaction with myosin SH1 was about 30 times faster than that with N-acetylcysteine (NAC). The reaction rate of TNB with SH1 was about twice compared with that of NEM, the most reactive selective reagent for SH1 so far found, although its rate with NAC was only one sixtieth that of NEM. As to the lambda max of the absorption spectrum of SH1-DNP-myosin, a large red shift of as much as 20 nm was observed compared with low molecular S-DNP derivatives. This red shift disappeared in 8 M urea. This outstanding feature of SH1 modification with TNB was discussed in terms of affinity labeling by interaction with an aromatic amino acid near SH1.

Adenosine Triphosphatases↗
PubMed1984

[Ultrastructural observations of human pancreatic duct cell carcinoma].

The great majority of human pancreatic duct cell carcinoma are thought to be of ductal origin and acinar cell carcinoma has been reported to be very rare. This paper reports electron microscopic observations of human pancreatic duct call carcinoma. The results were as follows. In the cases which were diagnosed as well or moderate differentiated adenocarcinoma of the pancreas by light microscope, three different types of tumor cells were observed by electron microscope. Two of them had characters of ductal cells. The origin of these tumor cells were considered to be originated from the relative large and small pancreatic ducts. Third type was a little different from cell types mentioned above. Some of these cells had swollen mitochondria and well developed rough endoplasmic reticulum with a various distribution of zymogen granules. Microvilli and cellular projects were scant. These findings were considered to be the dedifferentiation of the acinar cells and this type belonged to be acinar cell carcinoma.

Aged↗