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Biomedical subjects

K Philipp

Publications and source records attributed to K Philipp.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Improvement of utero-placental perfusion by transcutaneous nerve stimulation (author's transl)].

A report is given on 37 patients with a diminished utero-placental perfusion. 12 patients underwent only once, 25 patients daily over 2 to 3 weeks a transcutaneous lumbo-sacral electric nerve stimulation. Both, the 12 patients stimulated only once and the 25 patients with daily stimulation, showed a significant increase of utero-placental perfusion measured by the method of radioisotope placental perfusion. Transcutaneous nerve stimulation (TNS) therefore could be used for therapeutic purpose in cases of placental dysfunction.

Blood Circulation↗
PubMed1980

[Study of the utero-placental perfusion by means of a circulation model (author's transl)].

The radioactivity time curves recorded over the utero-placental unit after application of 250 microCi 113mIn-transferrin may be regarded as the sum of various functional factors and morphological components. In order to be able to evaluate the influence of one single factor on the course of the curve in-vitro experiments were performed using a circulation model and an artificial placenta designed by the authors. The experiments confirmed that a gradual rise of flow resistance - equal to that present in cases of EPH-gestosis - results in a gradual reduction of the flow. By simultaneously raising the systolic pressure the values recorded got normal lowering the systolic pressure to values equal to those observed in hypotension a gradual drop of the flow was evoked. The results show that a rise of flow resistance or a drop of the mean arterial pressure results in curves as seen in case of reduced maternal blood supply to the placenta.

Blood Circulation↗
PubMed1980

[Influence of duration of sterility on the course of pregnancy (author's transl)].

106 sterile patients who had become pregnant were divided into three groups depending on the duration of their sterility (3-5 years, 5-8 years, more than 8 years). Mostly within one year after treatment of sterility the women became pregnant independent on the duration of their sterility. Pregnant, former sterile patients showed a higher percentage of early and late abortions and of neonates with "low birth weight" (less than 2500 g) than a normal population, but there was not observed a relationship to the duration of sterility.

Abortion, Spontaneous↗
PubMed1980

[Results of routine removal of ovaries and/or tubes as part of vaginal hysterectomy (author's transl)].

Women of 48 years of age, who undergo a hysterectomy at the Ist Clinic of Gynecology and Obstetrics of the University in Vienna in addition get adnexectomied for prophylactic reasons. In younger patients only the tubes are removed. The results of 1472 hysterectomies show, that the vaginal route, which is chosen in 70% of all cases, leads in more than 95% to the satisfactory removal of tubes and ovaries without an increase of postoperative morbidity and mortality.

Adult↗
PubMed1980

[Modified measurement of placental blood flow at I Gynaecological Hospital of Vienna University (author's transl)].

Reported in this paper is a modification of placental blood flow measurement which is in use at the I. Gynaecological Hospital of the University of Vienna. An injection of 350muCi 113m-In-Transferrin was followed by computer-aided on-line recording of the radioactivity curve over the placenta, using a gamma scintillation camera. Radioactivity-time curves may be described by the e-function, At=A0(1-e-kt). The iterative regression method was used for mathematical evaluation, and the curve slope was printed out at zero by the computer (tgx at zero). The flow curves were attributable with good clinical relevance to three types of standard curves depending on curve shapes. The disadvantages of other methods are discussed.

Diagnosis, Computer-Assisted↗
PubMed1980

[Electronic data processing in irradiation of gyneocological cancer (author's transl)].

For statistical processing of data resulting from irradiation of gynecological cancer a system of EDP working off-line is presented. Not only healing and survival rates will be evaluated but also data about the morbidity of irradiated patients. Thereby the employed therapy should be improved. Moreover, the patient follow-up can be supervised by a special program with automatical summoning of negligent patients.

Austria↗
PubMed1979

[The effect of antibiotic prophylaxis in vaginal obstetric procedures (author's transl)].

202 cases of vaginal obstetric procedures (forceps and vacuum extraction, breech delivery and manual removal) were reviewed with regard to assessing the value of prophylactic administration of antibiotics. Criteria for the evaluation were fever post partum, duration of stay in hospital and involution of the uterus. The results showed that the prophylactic administration of antibiotics had no significant effect on these parameters, with or without the simultaneous administration of oxytocics. Hence, in view of the risk of allergic reactions, toxicity and the selection of resistant strains the prophylactic administration of antibiotics does not seem to be justified in vaginal obstetric procedures. Scrupulous aseptic precautions during all vaginal or intrauterine procedures are considered essential for the prevention of infection.

Adult↗
PubMed1979

[Results of a long-term clomiphene citrate therapy in women with normogonadotropic menstrual disturbanes (author's transl)].

A total of 72 pregnancies was achieved in 59 women with menstrual cycle disturbances (WHO Type II) by administration of clomiphene. 27 of these pregnancies (34.7%) occurred only after more than three courses of cloimphene. A secondary classification of the patients was based on the symptomatic severity of the menstrual disturbance. Clomiphene (100 mg) was administered on the fifth day after the onset of menstruation for five days, whereby in one or two cases up to 19 courses had to be given. The group consisted of women who had rejected HMG-HCG therapy because of the possibility of multiple pregnancy. 59 pregnancies went to full term; 2 tubal pregnancies and 11 cases of miscarriage were recorded. The commencement of pregnancy was evaluated and the time of ovulation and the length of the luteal phase determined in women requiring up to three courses of clomiphene and those requiring over three courses. The investigation demonstrates that clomiphene therapy can be successful even after more than six courses of the drug. Side effects are minimal.

Adult↗
PubMed1979

The results of isotope renography and intravenous pyelography in 420 patients with carcinoma of the uterine cervix.

A group of women with carcinoma of the cervix was studied by renography and i.v. pyelography. The incidence of renal and urinary tract disorders detected by these tests increased as did the stage of the disease, being 17.1% with Stage I carcinoma of the cervix, 27.8% with Stage II carcinoma of the cervix, 47% with Stage III carcinoma of the cervix, and 83.3% in Stage IV carcinoma of the cervix. In patients with Stage I and Stage II carcinoma of the cervix, those selected for radiotherapy had twice the incidence of abnormal renograms as those selected for surgery. This difference probably reflected a higher incidence of medical disorders affecting renal and urinary tract function in those considered unfit for surgery. We believe that renograms should be used routinely as a screening test in patients with carcinoma of the cervix.

Female↗
PubMed1979

A simple, versatile, sensitive and volume-independent method for quantitative protein determination which is independent of other external influences.

A method is described which in principle is a quantitative "spot analysis". 0.5-5 microliter of a protein solution in the concentration range between 0.01-10 mg/ml is used for one determination. The sample is taken up by capillary attraction in a 0.5-, 1-, 2- or 5-microliters capillary and transferred to a cellulose acetate strip. The protein is fixed and stained simultaneously by dipping the cellulose acetate strip into a solution of Amido Black or a benzoxanthene derivative (Hoechst 2495) dissolved in in methanol/acetic acid. After elution of the excess of dye (3 x 5 min) the quantitative evaluation can be performed in different ways: 1) The sample is fixed and made transpartent by incubation in dioxane/1-butanol and evaluated densitometrically (Amido Black 10B) or 2) the evaluation is performed in situ by spot fluorometry (Hoechst 2495). 3 The sample can be dissolved together with the acetate layer completely in dioxane, dimethylsulfoxide or N,N-dimethylformamide and evaluated photometrically or 4) fluorometrically. 5) Highest sensitivity is reached if the fluorochrome (Hoechst 2495) bound to the protein is eluted with 15% NH4OH and measured fluorometrically. There is a linear correlation with a correlation coefficient of 0.999 between the fluorescence and a protein amount of 10 ng-20 micrograms. In addition to its simplicity, the method has the advantage of being independent of or well-defined against other external influences, e.g., sodium dodecyl sulfate, mercaptoethanol, Triton X-100, etc. The stainability of a protein with Amido Black is influenced stoichiometrically by sodium dodecyl sulfate (not by mercaptoethanol) whilst the staining with Hoechst 2495 is not at all affected. As there is linear correlation between the area of a spot on an acetate layer and the volume applied in the range between 0.5 and 5 microliters, (only influenced stoichiometrically by the protein concentration in that volume, which in turn is measured by staining with Amido Black), then with a simple iterative calculation on the basis of suitable calibration curves, it is easily possible to determine a protein concentration in mg/ml even in an unknown volume between 0.5 and 5 microliters.

Capillary Action↗
PubMed1979

[The influence of TNS (transcutaneous nerve stimulation) on placental flow (author's transl)].

A report about 12. gravid patients with a diminished uteroplacental flow is given. To increase their placental perfusion a transcutaneus lumbo-sacral electric nerve stimulation was performed. In all 12 cases a distinet increase war measured by the method of radioisotope placenta-perfusion. The mean values showed a high significant difference (p less than 0,001). The reasons for this results and the possibilities of this findings for the therapy of funcitonal placental insufficiency are discussed.

Electric Stimulation↗
PubMed1979

[The influence of ritodrine-hcl (prepar), bunitrolol (stresson) and oxytocin (syntocinon) on Uteroplacental perfusion (author's transl)].

The administration of betamimetics has proved to be useful for symptom-oriented treatment in patients with reduced utero-placental flow. In order to quantify the betamimetic effect flow measurements were carried out in a total of 12 sheep, yielding the following experimental results: 1) Betamimetics, up to a certain point which correlates with maternal heart rate, raise the uteroplacental flow-rate. 2) The use of cardio-selective betablocker prevents undesired betamimetic side-effects but there is also a loss of the rise in utero-placental flow rate. 3) In sheep pretreated with Oxytoxin the application of betamimetics not only offsets oxytoxin-action but also greatly improves utero-placental blood flow.

Animals↗
PubMed1979

[The Le Veen peritoneo-jugular shunt and the testing of its function].

A radioisotope technique for testing the patency of, peritoneo-venous shunts of Le Veen, is reported and is demonstrated by discussing a case history. By now a total number of 16 patients have been tested, after implantation of such a shunt. The demonstrated radioisotope technique, which causes no complaints from the patient, is not only able to inform concerning the functional state of the Le Veen shunts, but also, in case of disturbances, is able to reveal the cause of the underlying malfunctions.

Ascites↗
PubMed1978

[Prophylactic medication to prevent miscarriage in pregnant women with a history of sterility (author's transl)].

A report is given of the outcome of 451 pregnancies occurring among women who had previously attended the Infertility Clinic. General gestagen therapy was given prophylactically in 129 cases before the appearance of any signs of threatened abortion. Massive gestagen therapy was initiated in 41 cases in response to signs of threatened abortion. Gestagen was not given either prophylactically or therapeutically in the remaining 281 pregnancies. The incidence of abortion was 10.1% in women given prophylactic gestagen, whilst the overall rate of abortion in the entire series of 451 women was 13.3%. It transpired on closer scrutiny of the 129 cases given prophylactic gestagen therapy that the abortion rate was 12.0% in the 108 pregnancies in which prophylactic gestagen therapy had been initiated at the time of the first missed period or later, whereas not one single abortion was registered amongst the 21 women who had been given gestagen therapy in the immediate post-ovulatory phase. It can be concluded that commencement of prophylactic gestagen therapy at the earliest possible moment provides optimum conditions for successful implantation of the fertilized ovum, especially in cases with masked insufficiency of the corpus luteum.

Abortion, Threatened↗